Chapter 5 Flashcards
0-10 wks old
embryo
Brain Weight @ birth
350 grams
Brain weight @ 1 yr
1000 grams
Brain weight as an Adult
1200 to 1400 grams
Production of new cells/neurons in the brain; primarily occurring early in life
proliferation
cells that remain where they are, continuing to divide
Stem cells
movement of cells after they have differentiated as neurons or glia to their eventual locations
migration
Migration guided by
immunoglobulins & chemokines
Process whereby neuron forms its axon & dendrites that gives the neuron its distinctive shape (axon 1st, followed by dendrites)
differentiation
process by which glia produce insulating fatty sheaths that accelerate transmission
myelination
formation of synapses between neurons; final stage
synaptogenesis
5 stages of growth & development of neurons
Proliferation, migration, differentiation, myelination, synaptogenesis
Can the adult vertebrate brain generate new neurons?
stem cells are undifferentiated; generate “daughter cells” that can transform into glia or neurons
songbirds
in area necessary for singing, old neurons die & new ones take their place
stem cells differentiate into new neurons in adult hippocampus
mammals
Roger Sperry & newts
indicated that axons follow a chemical trail to reach their appropriate target (1954)
Axons find their targets w/remarkable precision. How?
growing axon follows path of cells-surface molecules, attracted by some chemcials and repelled by others. This process steers it in the correct direction
Some theorists refer to the idea of the selection process of neural connectections as this; as nervous system develops, we start w/more neurons & synapses than we keep; in this competition amongst synaptic connections, we initially form more connections than we need; most successful
neural darwinism
discovered that muscles don’t determine how many axons form; they determine how many survive
levi montalcini
is a type of protein released by muscles that promotes the survival and growth of axons
Nerve Growth Factor (NGF)
Neuron’s suicide program
if it’s axon doesn’t make contact w/an appropriate postsynaptic cell by a certain age, the neuron kills itself thru a process called apoptosis
Preprogrammed mechanism of cell death
apoptosis
chemical that promotes survival & activity of neurons (NGF)
neurotrophin
most abundant neurotropin in adult cerebral cortex
BDNF (brain-derived neurotrophic factor)
Increased risk of heart problems on babies
antidepressant
condition marked by hyperactivity, impulsiveness, difficulty maintaining attention, varying degrees of mental retardation, motor problems, heart defects, & facial abnormalities (high forehead & wide set eyes)
Fetal Alcohol Syndrome
what characteristics do they show as adults?
suppresses glutamate & enhances the realase of GABA; many neurons consequently recieve less excitation & exposures
Both increased risk for ADHD & other behavioral deficits
cocaine & tobacco
can affect the health of child
stress
neurons in different parts of the brain differ. how?
from 1 another in their shape & chemical components
The brain has some limited ability to reorganize itself in response to experience
fine tuning by experience
After practicing particular skills connections relevant to those skills proliferate, while other connectons retract
new & interesting experiences
does this apply to humans?
yes; enriched environment are likely to have more branches
what about older ppl?
cortex gets smaller
Blind ppl outperform sighted ppl
verbal skills
larger than normal section postcentral gyrus in rihgt hemispehre devoted to representing finers of teh left hand
stringed instrument players
Aka Focal hand dystonia
Musician’s cramp
refers to a condition where the reorganization of the brain goes too far; the fingers of musicians who practice extensively become clumsy, fatigue easily, & make involuntary movements
Musican’s cramp
tendency to seek immediate reward or pleasure
impulsiveness
voluntary eye movement away from normal direction; ability to perform task improves sharply between ages 7 to 11 (looking away from a powerful attention-getter)
Antisaccade Task
“discount the future”
immediate rewards better than later risks/rewards/harms; teens do this
memory & reasoning beyond the age of 60
old age
abstract reasoning; goes down w/age
fluid intelligence
what you know about world; common facts, what you’ve seen, experience, read, etc.; goes up w/age
crystal intelligence
sharp blow to the head resulting from an accident, assault, or other sudden trauma that doesn’t puncture the brain
closed head injury
2 causes of closed head injury
rotational forces & blood cots
drive brain tissue against skull
rotational forces
flow of blood to brain is interrupted
blood cots
temporary loss of blood flow to a brain area; common cause of brain damage in old ppl
stroke (cerebrovascular accident)
result of blood clot or other obstruction in an artery; more common
ischemia
neurons are deprived of blood & lose much of their oxygen & glucose supplies
ischemia
result of ruptured artery; neurons are flooded w/blood & excess oxygen, calcium, & other chemcials; less common
hemorrhage
causes edema
Ischemia & hemorrhage
accumulation of fluid which increases pressure on brain & probability of additional strokes
edema
overstimulates neurons
glutamate
the region surrounding the immediate damage
penumbra
the decreased activity of surviving neurons after damage to other neurons
diaschisis
ways to stimulate brain:
electrical stimulation, stimulant drugs, other stimulants
man in “minimally conscious state” for 6 yrs was given electrical stimulation to central thalamus
electrical stimulation
injection of amphetamines enhanced behavior in brain damaged rates & cats
stimulant drugs
why don’t you want to calm a stroke victim w/tranquilizers?
decrease dopamine thus make it harder for person to recover
the brain continually adds new branches of axons & dendrites while w/drawing old ones
sprouting
after loss of a set of axons, cells that lost their source of innervation react by secreting neurotrophins to induce other axons to form new brancehs OR
collateral sprouts
formed by other non-damaged axons that attach vacant receptors
collateral sprouts
heightened sensitivity to a neurotransmitter after the destruction of an incoming axon; can cause chronic pain
denervation supersensitivity
heightened sensitivity as a result of inactivity by an incoming axon
Disuse Supersensitivity
refers to the continuation of sensation of an amputated body part; can range from tingling to intense pain
phantom limb
a limb that has lost its afferent (sensory input)
deafferented limbs
When does the CNS begin to form?
When the embryo is Approximately 2 wks old
Development of new neurons also occurs in other brain regions
TRUE
All cells have the same life span
FALSE; different cells have different avg life spans
After maturity the apoptotic mechanisms become dormant
TRUE
Why is the visual cortex actually thicker in blind ppl?
Because of a lack of visual stimuli; it cannot prune out ineffective neurons.
A mutation on one gene can lead to a few defects
FALSE; leads to MANY defects
Conditioned marked by: hyperactivity & impulsiveness, difficulty maintaining attention, varying degrees of mental retardation, motor problems & heart defects, facial abnormalities
Fetal Alcohol Syndrome; mother drinks too much during pregnancy
Dendrites of children born w/fetal alcohol syndrome are…
short w/few branches
Exposure to alcohol in the fetus brain…
suppresses glutamate & enhances the release of GABA
Relates to learning
gain & loss of spines indicates new connections
____________ declines in old age
the thickness of the cerebral cortex
Once believed that teahing a child a difficult concept would enhance intelligence in other areas
“far transfer”
May account for the fact that blind ppl often have enhanced tactile senses & increased verbal skills
the occipital lobe normally dedicated to processing visual info adapts to also process tactile & verbal info
AKA “Musicians Cramp” refers to a condition where the reorganization of the brain goes too far
Focal Hand dystonia
Focal hand dystonia
fingers of musicians who practice too much become clumsy, fatigue easily, and make involuntary movements; touch responses to one finger overlap those of another
Looking away from a powerful attention-getter; imporves gradually during the teen yrs
Antisaccade Task
Possible causes of brain damage include
tumors, infections, exposure to toxic substances, degenerative diseases, close head injuries
a sharp blow to the head that doesn’t puncture the brain; 1 of the main causes of brain injury in young adults
A closed head injury
AKA cerebrovascular accident; temporary loss of blood flow to brain
Stroke
Neurons are flooded w/excess blood, calcium, oxygen, & other chemicals
hemorrhage
neurons lose their oxygen & glucose suppy
Ischemia
Most effective lab methods used to min. damage caused by strokes
cool the brain
decreased activity of surviving neurons after damage to other neurons
diaschisis
What is the process called when a primitive neuron begins to develop dendrites and an axon? Myelination Migration Differentiation proliferation
Differentiation
Which of the following would most likely interfere with migration of neurons during development?
a. altering the chemical paths
b. damaging dendrites
c. loss of myelin
d. increased differentiation
altering the chemical paths
Why is it that all neurons in a healthy adult brain have made appropriate connections?
If an axon does not make the appropriate connections by a certain age, it dies.
The function of neurotrophins is to:
promote survival of axons.
What brain abnormalities are found in children with fetal alcohol syndrome?
short dendrites with few branches
After damage to a set of axons, neurotrophins induce nearby:
uninjured axons to form new branches.
Ischemia and hemorrhage kill neurons by:
overstimulating them.
Suppose a finger is amputated. The part of the cerebral cortex that used to respond to that finger will:
become responsive to other fingers or part of the palm.
One way to relieve the pain associated with a phantom limb is to:
have the amputee learn to use an artificial limb.