Chapter 3 Flashcards
Communication between neurons is PRIMARILY ________
chemical
Specialized gap between neurons
synapse
Discovered narrow gap between neurons
Ramon y Cajal
Demonstrated that communication between one neuron & the nxt differs from communication along single axon
Charles Scott Sherrington
Automatic muscular responses to stimuli
Reflexes
Circut from sensory neuron to muscle response
Reflex Arc
Repeating stimuli w/in a brief time have a cumulative effect
Temporal summation
the cell that RECEIVES a msg
Postsynaptic Neuron
Cell that DELIVERS the transmission
Pre-Synaptic Neuron
Graded depolarization; occurs when sodium ions enter the cell; that decays over time & space; Discovered by Eccles
Excitatory Postsynaptic Potential (EPSP)
Synaptic inputs from various locations combine their effects of a neuron.
Spatial Summation
How did Sherrington discover this?
Pinch a dog’s foot; one time=nothing; but several pinches did
Ordinarily Occur together…
Temporal summation & spatial summation
Hyperpolarizes
increases the negative charge w/in the cell, moving it further from the threshold & decreasing the probability of an action potential
Occurs when the synaptic input selectively opens the channel for potassium ions to leave the cell or for chloride ions to enter the cell
Inhibitory Postsynaptic Potential (IPSP)
The importance of Sherrington’s work
led to researcher’s being able to show how nervous system was wired & make a diagram
Peridoic reproduction of action potentials even w/out synaptic input
spontaneous firing rate
1st to suggest that synapses operated by using chemicals (adrenaline) as means of transmitting signals (British)
T.R. Elliot
Won the Nobel Prize for his work w/chemical synapses; 1st to convincingly demonstrate that communicate across the synapse occurs via chemical means (German)
Otto Loewi
Chemicals released by one neuron that affect a second neuron
Neurotransmitter
Acids containing an amine group (NH2)
Amnio Acids
Chains of amino acids
Neuropeptides
Chemical similar to amino acid, except that NH2 group has been replaced by N(CH3) group (one member “family”)
Acetylcholine
Neurotransmitters containing one amine group (NH2), formed by a metabolic changed in certain amino acids
Monoamines