Chapter 4 BNF (Substance Abuse)

Question 1

what drugs are used in assisted alcohol withdrawal?

Answer 1

Chlordiazepoxide
Diazepam

Carbamazepine
Clomethiazole (inpatient setting)

Question 2

What’s the treatment for alcohol withdrawal seizures?

Answer 2

Lorazepam (fast acting)

Question 3

What’s the treatment for delirium tremens ?

Answer 3

Oral lorazepam

Or

Parenteral lorazepam/ haloperidol

Question 4

What’s the pharmacological treatment for alcohol dependence?

Answer 4

Acamprostate
Naltrexone

Disulfram

Question 5

What OTC medication should disulfram patients avoid?

Answer 5

Alcohol mouthwash

Question 6

What can be offered patients without withdrawal symptoms and don’t need immediate detox?

Answer 6

Nalmefenw

Question 7

What can be used to treat wernickes encephalopathy?

Answer 7

Thiamine

Question 8

What prolonged release formulations are available for smoking?

Answer 8

16hr / 24hr patch

Question 9

What immediate release formulations are available for tackling cravings?

Answer 9

Gum
Lozenge
Nasal spray
Oral spray 
Sublingual tablet 
Inhalator

Question 10

What is the mechanism of action for varenicline?

Answer 10

Partial nicotine agonist

Question 11

What is the MHRA alert on veranicline?

Answer 11

Suicidal thoughts

Question 12

What are the side effects of nicotine replacement therapy?

Answer 12

Local irritation

Question 13

Can bupropion and verinicline be used together

Answer 13

No

Question 14

What are the side effects of methadone?

Answer 14

QT prolongation

Question 15

When should buprenorphine be initiated?

Answer 15

On withdrawal symptoms

6-12 hrs after heroin
24-48 hrs after methadone