Chapter 4 BNF (Movement Disorders) Flashcards

1
Q

What is parkinsons disease?

A

progressive dopamine deficiency in the nigrostriatal pathway

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2
Q

what are the motor symptoms in parkinsons disease?

A

hypokinesia
bradykinesia
rigidity
tremor

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3
Q

what are the non motor symptoms in parkinsons disease?

A

dementia
depression
sleep disturbance

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4
Q

who must the patient notify after diagnoses of parkinson’s disease?

A

DVLA

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5
Q

Why must parkinsons disease medication never be stopped abruptly?

A

Akinesia

NMS

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6
Q

Whats first line in parkinson’s disease with symptoms that affect quality of life?

A

LEVODOPA

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7
Q

What is first line in parkinson’s disease with symptoms that do not affect quality of life?

A

LEVODOPA
MAO-B inhibitors
Non-ergot derived dopamine agonists

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8
Q

What can be offered for Dyskinisea and motor fluctuations in parkinsons disease?

A

MAO-B
Non ergot DA
COMT inhibitors

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9
Q

What can be given for Advanced Parkinsons disease?

A

Apomorphine IV or SC

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10
Q

What are the side effects of Apomorphine?

A

N and V

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11
Q

How is Apomorphine induced nausea and vomiting treated? What must you be careful of?

A

Domperidone

both drugs cause QT prolongation

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12
Q

What are the 4 hallmarks of levodopa side effects?

A

end of dose deterioration
impulse disorder
excessive sleeping
motor complications

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13
Q

what are the 4 hallmarks of non ergot da side effects?

A

hypotension
worse impulse control
psychotic symptoms
fibrolytic reactions (worse with ergot)

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14
Q

What is the notable risk with MAO-B inhibitors?

A

Hypertensive crises

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15
Q

What are the side effects with COMT inhibitors?

A
hepatotoxicity (tolcapone)
colour urine (entacapone)
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16
Q

Name some ergot derived dopamine agonists?

A

bromocriptine
cabergoline
pergolide

17
Q

Name some non-ergot derived dopamine agonists?

A

Pramipexole
Ropinerole
Rotigotine

18
Q

Name some MAO-B Inhibitors?

A

selegiline

rasagiline

19
Q

name some COMT inhibitors?

A

entacapone

tolcapone