Chapter 23 Flashcards
__ take urine from kidneys to urinary bladder to be stored
Ureters
what are the functions of the kidneys
- Filter blood and excrete toxic metabolic wastes
- Regulate blood volume, pressure, and osmolarity
- Regulate electrolytes and acid-base balance
- Secrete erythropoietin, which stimulates the production of red blood cells
- Help regulate calcium levels by participating in calcitriol synthesis
- Clear hormones from blood
- Detoxify free radicals
- In starvation, they synthesize glucose from amino acids
what is the definition of waste
any substance that is useless to the body or present in excess of the body’s needs
what is the definition of metabolic waste
waste substance produced by the body
ammonia is produced by __ and is then converted to
the catabolism of proteins, urea
Creatinine comes from __which is made from certain amino acids which come from proteins
creatine
Uric acid comes from
nucleic acids
urea makes up about __% of nitrogenous wastes
50
what does BUN stand for
blood urea nitrogen
what is blood urea nitrogen
level of nitrogenous waste in blood
Normal concentration of blood urea is
10 to 20 mg/dL
what is azotemia
elevated BUN
May indicate renal insufficiency due to nephron destruction
what is uremia
syndrome of diarrhea, vomiting, dyspnea, and cardiac arrhythmia stemming from the toxicity of nitrogenous waste
Develops at 90% loss of renal function
what is the treatment for uremia
hemodialysis or organ transplant
__can tell you if the blood is being cleared of nitrogenous waste
BUN
what is the definition of excretion
separating wastes from body fluids and eliminating them
what are the four body systems that carry out excretion
respiratory, integumentary, digestive, and urinary
what is excreted from the respiratory system
CO2, small amounts of other gases, and water
what is excreted from the integumentary system
water, inorganic salts, lactic acid, urea in sweat
what is excreted from the digestive system
water, salts, CO2, lipids, bile pigments, cholesterol, and other metabolic waste
what is excreted from the urinary system
many metabolic wastes, toxins, drugs, hormones, salts, H+, and water
where are the kidneys located
at the level of T12 to L3
the __ kidney is slightly lower due to th large lobe of the liver
right
how big are the kidneys
about the size of a bar of soap
what is the slit in the kidneys called
the hilum
what are the protective connective tissue coverings
renal fascia, perirenal fat capsule, and the fibrous capsule
where is the renal fascia located
Immediately deep to parietal peritoneum
Binds it to abdominal wall
what does the perineal fat capsule do
cushions kidney and holds it into place
what does the fibrous capsule of the kidneys do
encloses kidney protecting it from trauma and infection
what is renal parenchyma
glandular tissue that forms urine, encircles the renal sinus
what is the renal sinus
cavity that contains blood and lymphatic vessels, nerves, and urine-collecting structures. Adipose fills the remaining cavity and holds structures in place
what are the renal columns
extensions of the cortex that project inward toward sinus
what are the renal pyramids
6 to 10 with broad base facing cortex and renal papilla facing sinus
what are the lobes of the kidneys
one pyramid and its overlying cortex
what is a minor calyx
cup that nestles the papilla of each pyramid; collects its urine
what are the three major calyces
formed by convergence of 2 or 3 minor calyces
what is the renal pelvis
formed by convergence of 2 or 3 major calyces
what are the ureters
a tubular continuation of the pelvis that drains urine down to the urinary bladder
Kidneys are only __% of body weight, but receive about __% of cardiac output
0.4, 21
In the cortex, efferent arterioles give rise to __supplying the tissue near the glomerulus- the proximal and distal convoluted tubules
peritubular capillaries
In the medulla, efferent arterioles give rise to the __, supplying the nephron loop portion of the nephron
vasa recta
each kidney has about __ nephrons
1.2 million
each nephron is composed of two principal parts
the renal corpuscle and the renal tubule
what does the renal corpuscle do
filters blood plasma
what does the renal tubule do
long, coiled tube that converts the filtrate into urine
Renal corpuscle consists of the __ and a two-layered __ that encloses glomerulus
glomerulus, glomerular capsule
the parietal layer of the glomerular capsule is made of
simple squamous epithelium
the visceral layer of glomerular capsule consists of __ that wrap around the capillaries of the glomerulus
podocytes
what is the vascular pole
the side where the afferent arterial enters and the efferent arteriole leaves the corpuscle
what is the urinary (tubular) pole
where the renal tubule begins
what is the renal tubule
the duct leading away from the glomerular capsule and ending at the tip of the medullary pyramid
what are the four regions of the renal tubule
proximal convoluted tubule, nephron loop, distal convoluted tubules and the collecting duct
what regions of the renal tubule are parts of a single nephron
proximal convoluted tubule, nephron loop, and the distal convoluted tubules
Glomerular filtrate goes into glomerular capsule then becomes
tubular fluid
what is the proximal convoluted tubule made out of and what is it known for
simple cuboidal epithelium and it is the longest and most coiled region of a nephron
the nephron loop has a __ limb and a __ limb
descending and ascending
thick segments of the nephron loop have__ while thin segments have__
simple cuboidal epithelium, simple squamous epithelium
the distal convoluted tubule is made of __ and is special because
simple cuboidal epithelium, it is the end of the nephron
___ nephrons consist of 15% of all nephron
juxtamedullary
what do juxtamedullary do
maintain salinity gradient in the medulla and help conserve water
cortical nephrons consists of __% of nephrons
85
are cortical nephrons short or long
short
where are cortical nephrons found
in the cortex of the kidney but very few will extend into the medulla
what does the collecting duct do
receives fluid from the DCTs of several nephrons as it passes back into the medulla
Numerous collecting ducts converge toward the
tip of the medullary pyramid
the papillary duct is formed by
merger of several collecting ducts
The collecting duct receives tubular filtrate, then the fluid continues down to the papillary duct and is then considered
urine
what is the flow of fluid from the point where the glomerular filtrate is formed to the point where urine leaves the body
glomerular capsule → proximal convoluted tubule → nephron loop → distal convoluted tubule → collecting duct → papillary duct → minor calyx → major calyx → renal pelvis → ureter → urinary bladder → urethra
what is the renal plexus
nerves and ganglia wrapped around each renal artery
what are the functions of the renal plexus
- Follows branches of renal artery into the parenchyma of the kidney
- Issues nerve fibers to blood vessels and convoluted tubules of the nephron
- Carries sympathetic innervation from the abdominal aortic plexus
- Stimulation reduces glomerular blood flow and rate of urine production
- Respond to falling blood pressure by stimulating the kidneys to secrete renin, an enzyme that activates hormonal mechanisms to restore blood pressure
the kidneys receive __ innervation of an unknown function
parasympathetic
kidneys convert blood plasma to urine in what four stages
- Glomerular filtration
- Tubular reabsorption
- Tubular secretion
- Water conservation
what is glomerular filtrate
the fluid in the capsular space
glomerular filtrate is similar to blood plasma except that is has almost no
protein
what is tubular fluid
fluid from the PCT through the DCT
what is urine
fluid that enters the collecting duct
The collecting tubules are a little passage way from the __ to the
distal convoluted tubule, collecting duct
When fluid hits the __that is when it is formally called urine
papillary duct
glomerular filtration creates a __like filtrate of the blood during urine formation
plasma
___ removes useful solutes from the filtrate returns them to the blood during urine formation
tubular reabsorption
__ removes additional wastes from the blood, adds them to the filtrate during urine formation
tubular secretion
__ removes water from the urine and returns it to the blood and concentrates wastes
water conservation
what is globular filtration
the movement of substances from the blood within the glomerulus into the capsular space
what is tubular reabsorption
the movement of substances from the tubular fluid back into the blood
what is tubular secretion
the movement of substances from the blood into the tubular fluid
what are the three barriers of the filtration membrane
fenestrated endothelium, basement membrane, and the filtration slits
how large are the filtration pores and why
70-90 nm, they are small enough to exclude blood cells
T?F fenestrated endothelium are highly permeable
true
the proteoglycan gel of the basement membrane excludes molecules greater than
8nm
albumin is repelled by
negative charge
Blood plasma is __% protein, the filtrate is only __% protein
7, 0.03
Podocyte cell extensions wrap around the capillaries to form a barrier layer with __ nm filtration slits
30
filtration slits are negatively/positively
negatively
what are fenestrations
types of pores or spaces that are of a certain size
Kidney infections and trauma can damage the __and allow albumin or blood cells to filter
filtration membrane
what is proteinuria
the presence of protein in urine
what is hematuria
the presence of blood in the urine
Distance runners and swimmers often experience temporary __ or__
proteinuria, hematuria
__ reduces profusion of kidney
Prolonged, strenuous exercise
Glomerulus deteriorates under
prolonged hypoxia
Filtration pressure depends on
hydrostatic and osmotic pressures on each side of the filtration membrane