Chapter 18 Part I: Endocrine System Flashcards
Introduction to the Endocrine System
• Glands release hormones.
• Hormones regulate the many and varied functions of an organism.
• Hormones bind to receptors.
• Receptors are recognition sites in the various target tissues on which hormones act.
Introduction to the Endocrine System (Cont’d)
• ENDOCRINE glands-
Secrete their hormones directly into the bloodstream.
• EXOCRINE glands-
Send chemical substances (tears, sweat, milk, saliva) via ducts to the outside of the body.
Endocrine Glands
• Thyroid gland
• Parathyroid glands (four glands)
• Adrenal glands (one pair)
• Pancreas (islets of Langerhans)
• Pituitary gland
• Ovaries (one pair)
• Testes (one pair)
• Pineal gland
• Thymus gland
Endocrine Tissue (Apart from Major Glands): Location, Secretion, and Action: Body cells
Secretion:
- Prostagladins
Action:
- Aggregation of platelets
- Contract uterus
- Lower acid secretion in stomach
- Lower blood pressure
Endocrine Tissue (Apart from Major Glands): Location, Secretion, and Action: Gastrointestinal tract
Secretion:
- Cholecystokinin
- Gastrin
- Secretin
Action:
- Contracts gallbladder
- Stimulates gastric secretion
- Stimulates pancreatic enzymes
Endocrine Tissue (Apart from Major Glands): Location, Secretion, and Action: Kidney
Secretion:
- Erythropoietin
Action:
- Stimulates erythrocyte production
Endocrine Tissue (Apart from Major Glands): Location, Secretion, and Action: Pineal gland
Secretion:
- Melatonin
Action:
- Induces sleep and affects mood
Endocrine Tissue (Apart from Major Glands): Location, Secretion, and Action: Placenta
Secretion:
- Human chorionic gonadotropin
Action:
- Sustains pregnancy
Endocrine Tissue (Apart from Major Glands): Location, Secretion, and Action: Skin
Secretion:
- Vitamin D
Action:
- Affects absorption of calcium
Endocrine Tissue (Apart from Major Glands): Location, Secretion, and Action: Thymus
Secretion:
-Thymosin
Action:
- Affects immune response
Thyroid Gland Continents Top to Bottom:
- Thyroid cartilage
- Thyroid gland
- Isthmus
- Trachea
Thyroid Function
• There are two hormones:
- Thyroxine or tetraiodothyronine (T4)
- Triiodothyronine (T3)
• Thyroid hormones aid cells in their uptake of oxygen and regulate metabolic rate.
• Calcitonin: stimulates calcium to leave the blood and enter the bone.
Thyroid Gland: Hormones and Actions
- T3 (triiodothyronine): increases metabolism
- T4 (thyroxine): increases metabolism
- Calcitonin: decreases blood calcium
Parathyroid Gland Continents Top to Bottom:
- Epiglottis
- Pharynx
- Thyroid gland
- Parathyroid glands
- Esophagus
- Trachea
Parathyroid Glands
Secrete parathyroid hormone (PTH) which increase blood calcium.
Parathyroid Function
Parathyroid hormone (PTH): causes calcium to mobilize from bones into the bloodstream.
• Calcitonin vs PTH: range of blood calcium level tightly regulated!!
Calcium
• Calcitonin vs PTH: range of blood calcium level tightly regulated!!
• Calcium: hypercalcemia or hypocalcemia.
- Stronger bones and teeth
- Muscle contraction
- Nerve impulse transmission
- Blood clotting
- Release of hormones
Adrenal Glands: Suprarenal Glands: Continents from Top to Bottom:
- Adrenal cortex
- Adrenal medulla
- Kidney
- Ureter
(All connected to blood vessels)
Adrenal Glands: Location and Structure
Each gland has two parts:
- An outer portion, the adrenal cortex.
• Secretes corticosteriods or steriods, chemicals derived from cholesterol. - An inner portion, adrenal medulla.
• Secretes catecholamines chemicals derived from amino acids.
Function: Adrenal Cortex Secretes
• Glucocorticoids: influence metabolism of sugars, fats, and proteins (cortisol) and are anti-inflammatory (cortisone). Influences -SUGAR.
• Mineralocorticoids: regulate electrolytes.
- Aldosterone: reabsorption of
sodium/excretion of potassium. Influences- SALT.
• Gonadocorticoids: androgens and estrogens. Influences-SEX.
Function: Adrenal Medulla Secretes
• Two types of catecholamine hormones:
- Epinephrine (adrenaline): increases heart rate and blood pressure, dilates bronchial tubes, releases glucose from storage.
- Norepinephrine (noradrenaline):
constricts vessels to raise blood pressure. - Both are sympathomimetic agents.
The Adrenal Cortex (Corticosteroids) Secretions:
- Glucocorticoid: Cortisol: Increases blood glucose.
- Mineralocorticoid: Aldosterone: Increases salt (sodium) reabsorption.
- Sex hormones: Androgen and Estrogen: Sexual characteristics.
The Adrenal Medulla (Catecholamines) Secretions:
- Epinephrine (adrenaline)
- Norepinephrine (noradrenaline)
- Both are Sympathomimetic
Pancreas
• Located near and partially behind the stomach.
• Exocrine and endocrine organ.
Pancreas Function
Endocrine function
• Islets of Langerhans produce:
- Insulin: promotes movement of glucose into cells and promotes storage as glycogen.
- Glucagon: promotes movement of glucose into the blood by breaking down glycogen stored in liver cells.
(Glycogen= sugar store (glucose))
Pancreas Function (cont’d)
Pancreas (islet cells) produce insulin and glucagon.
Insulin: lowers blood sugar (glucose to glycogen). (glycogenesis)
Glucagon: raises blood sugar (glycogen to glucose). (glycogenolysis)
Pituitary Gland
• Pea-sized gland in depression of skull (sella turcica) also called the hypophysis.
> Anterior lobe (adenohypophysis).
> Posterior lobe (neurohypophysis).
• Hypothalamus controls secretions of the pituitary via releasing factors (hormones).
Pituitary Gland (cont’d)
- Cerebrum
- Pituitary gland (in sella turcica)
- Adenohypophysis
- Neurohypophysis
- Hypothalamus
- Pons
Relationship of the Hypothalamus to the Pituitary Gland:
- Hypothalamus: secretes releasing and inhibiting factors via capillaries to the anterior pituitary (adenohypophysis) which secretes hormones.
- Hypothalamus: secretes hormones directly to the posterior pituitary (neurohypophysis) which stores and releases hormones.
Pituitary Function
• Anterior pituitary
> Growth hormone (GH) or somatotropin (STH).
> Thyroid-stimulating hormone (TSH; thyrotropin).
> Adrenocorticotropic hormone (ACTH).
> Gonadotropic hormones (FSH, LH).
> Prolactin (PRL).
Pituitary Function (cont’d)
• Posterior pituitary: stores and releases hormones synthesized in the hypothalamus.
> Antidiuretic hormone (ADH; vasopressin).
> Oxytocin (OT).
Pituitary Gland: Hormones and Actions: Anterior Pituitary
- Adrenocorticotropin: Adrenocorticotropic hormone (ACTH): Stimulates adrenal cortex.
- Gonadotropin: Follicle-stimulating hormone (FSH): Stimulates ovaries and testes.
- Gonadotropin: Luteinizing hormone (LH): Promotes ovulation; stimulates testes.
- Somatotropin: Growth hormone (GH): Stimulates growth.
- Thyrotropin: Thyroid-stimulating hormone (TSH): Stimulates thyroid gland.
- Prolactin (PRL): Stimulates milk production.
Pituitary Gland: Hormones and Actions: Posterior Pituitary
- Vasopressin: Antidiuretic hormone (ADH): Increases water reabsorption.
- Oxytocin: Stimulates labor.
Ovaries and Testes: Hormones and Actions: Ovaries
- Estrogen: Estradiol: Female sexual characteristics.
- Progesterone: Maintains pregnancy.
Ovaries and Testes: Hormones and Actions: Testes
Androgen: Testosterone: Male sexual characteristics.
Male
Testes
- Hormone testosterone: Maintains germ cell formation and secondary sexual characteristics.
Female
Ovaries
- Hormones: estrogen and progesterone: maintains menstrual cycle, release of ovum, secondary sexual characteristics, preparation of uterus for pregnancy.
Adrenal cortex
Outer section of each adrenal gland; secretes cortisol, aldosterone, and sex hormones.
Adrenal medulla
Inner section of each adrenal gland; secretes epinephrine and norepinephrine.
Ovaries
Located in the lower abdomen of female; responsible for egg production and estrogen and progesterone secretion.
Pancreas
Located behind the stomach.
Parathyroid glands
Four small glands on the posterior of the thyroid gland.
Pituitary gland (hypophysis)
Located at the base of brain in the sella turcica.
Testes
Two glands enclosed in the scrotal sac of a male; responsible for sperm production and testosterone secretion.
Thyroid gland
Located in the neck on either side of the trachea; secretes thyroxine, triiodothyronine, and calcitonin.
adrenaline (epinephrine)
Secreted by the adrenal medulla; increases heart rate and blood pressure.
Adrenocorticotropic hormone (ACTH)
Secreted by the anterior lobe of the pituitary gland; stimulates adrenal cortex.
Aldosterone
Secreted by the adrenal cortex; increases salt reabsorption.
Androgen
Male hormone secreted by the testes and adrenal cortex (to a lesser extent).
Antidiuretic hormone (ADH)
Secreted by the posterior lobe of the pituitary gland; increases reabsorption of water by kidney.