Chapter 13 Part II: Blood Flashcards
Diseases of Red Blood Cells: Anemia
A deficiency in erythrocytes or hemoglobin.
Other types of anemia:
- Aplastic anemia
- Hemolytic anemia
- Pernicious anemia
- Sickle cell anemia
- Thalassemia
Types of Anemia: Aplastic anemia
Failure of blood cell production due to aplasia or absence of cell formation of bone marrow cells.
Types of Anemia: Hemolytic anemia
Reduction in red cells due to excessive destruction.
Types of Anemia: Pernicious (megaloblastic) anemia
Lack of mature erythrocytes caused by inability to absorb vitamin B12 into the bloodstream.
(Large, immature megaloblasts)
Pathology: An/emia
Deficiency in RBC or hemoglobin.
- Iron deficiency is most common.
- Microcytic RBC, increased hypochromic center of RBC.
Pathology: Aplastic anemia (-plasia means development or formation)
Failure of blood cells to develop in bone marrow, usually idiopathic.
- Pancytopenia: stem cells fail to produce all cells (RBC, WBC, platelets).
- Blood transfusion to prolong life.
- Bone marrow transplant???
Types of Anemia: Sickle cell
Hereditary disorder of abnormal hemoglobin producing sickle shape erythrocytes and hemolysis.
(Crescent-shaped, distorted, fragile cells)
Types of Anemia: Thalassemia (target cells)
An inherited defect in the ability to produce hemoglobin, leading to hypochromia.
(Hemoglobin concentration is low)
Types of Anemia: Hemochromatosis
Excess iron deposits throughout the body.
Types of Anemia: Polycythemia vera
General increase in red blood cells.
Sickle Cell Anemia
Hereditary (abnormal hemoglobin S): crescent or sickle shape of RBC with hemolysis as cells are fragile and cannot pass through capillaries.
Signs and Symptoms: arthralgia, abdominal pain, ulceration of extremities.
Prevalent in African descent.
Types of Anemia: Hereditary Spherocytosis
(Red cells are less biconcave and fragile)
Normal Red Blood Cells
(Biconcave shape)
Sickle Cell Disease: Vaso-occlusive crisis (thrombotic)
Crisis because blood vessel is starting to become obstructed, increasing the risk of thrombotic lesions.
Disorders of Blood Clotting: Hemophilia
Excessive bleeding caused by the lack of one of the protein substances necessary for blood clotting; patients often bleed into weight-bearing joints, especially the ankles and knees.
Disorders of Blood Clotting: Purpura
Multiple pinpoint hemorrhages and accumulation of blood under the skin.
Diseases of White Blood Cells: Leukemia
An increase in cancerous white blood cells.
- Acute myelogenous leukemia (AML)
- Acute lymphocytic leukemia (ALL)
- Chronic myelogenous leukemia (CML)
- Chronic lvmphocytic leukemia (CLL)
Diseases of WBC: Leukemia
Increased cancerous WBC (leukocytes).
- Acute: immature leukocytes.
- Chronic: mature leukocytes.
- Malignant WBC’s fill the bone marrow and blood stream.
- Treat with chemotherapy (anti-cancer meds, radiation, bone marrow transplant,,,).
Diseases of WBC: Remission
Disappearance of signs/symptoms of disease.