Chapter 13 (lecture microbe-Human interactions Flashcards
Normal Microbiota
microbes that permanently colonize
Transient Microbita
Present periodically
sites known to habor microbota
skin and adjacent mucous membrane, upper respiratory tract, gastrointestinal tract, including mouth, external genitalia, vagina, external ear canal, external eye
Pathogens
disease-causing microorganisms
True pathogens
make anbody sick
opportunistic pathogens
take advantage of any situation
Pathology
study of the cause, manner, and results of disease
Factors That Weaken Host Defenses and Increase Susceptibility to Infection
-Age: the very young and the very old
-Genetic defects in immunity and acquired defects in immunity (AIDS)
-Pregnancy
-Surgery and organ transplants
-Underlying disease: cancer, liver malfunction, diabetes
-Chemotherapy/immunosuppressive drugs
-Physical and mental stress
Other infections
What is the first step of an infection?
getting in (portal of entry)
What are ways of portal of entry?
-skin
-mucous membrane
-GI tract
-Respiratory
-urogenital
What is the second step of an infection?
staying in (attaching firmly and negotiating the microbe)
what are the ways for the infection to stay?
fimbriae, capsules, and spikes (virsues)
What is the third step of an infection?
surviving host defenses
What are the antiphagocytic factors of surviving host defenses?
-leukocidins (toxic to white blood cells)
-capsules
-survive within
-epigenetic changes to host
What is the fourth step of an infection?
Causing Disease
What are the three ways that microbes cause damage to hosts
-By secreting proteins (enzymes or toxins) that directly damage host cells
-By causing an overreaction by the body’s defenses and those defenses cause host damage
-By altering the host cell genome or transcription processes through epigenetic changes that temporarily or permanently disrupt normal host cell function.
What is a toxin
a chemical product of the one organism that is poisonous to another
What is a endotoxin?
A toxin molecule secreted by a living bacterial cell into the infected tissues
What is a exotoxin?
A toxin that is not actively secreted but is shed from the outer membrane
What is systemic infection?
which the pathogen spreads through circulation to many sites