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Immunohematology Lec > CHAP 10 SUMMARIZED > Flashcards

CHAP 10 SUMMARIZED Flashcards

1
Q

Labeling Requirements for Blood and Components
• (?) symbology
• (?) of product
• (?) of preparation (whole blood, apheresis)
• Storage (?)
• Preservatives/(?)
• (?) in pooled components
• (?) of collection & processing facility
• (?) (& time if applicable). When expiration time not indicated, expiration is at midnight.
• Identification number for unit or pool
• Donor category (volunteer, autologous)
• (?), if applicable.
• (?)information
• (?) regarding recipient identification, Circular of Information, infectious disease risk, & prescription requirement
• (?): “For Autologous Use Only.”
Biohazard label if any infectious disease markers are pos or “Donor Untested” if testing not performed.

A

ISBT 128 bar-code

Name

Method

temperature

anticoagulant

Number of units

Name, address, registration number, & license number

Expiration date

ABO group & Rh type

Special handling

Statements

Autologous units

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2
Q

Rapid blood loss

A

Whole blood

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3
Q

Neonatal exchange transfusion

A

Whole blood

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4
Q

Symptomatic anemia

A

Packed RBCs

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5
Q

Avoid febrile or allergic transfusion reactions

A

Deglycerolized RBCs

Washed RBCs

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6
Q

WBC antibodies

A

Leukocyte-poor RBCs

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7
Q

DIC

A

FFP

Platelets

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8
Q

Vitamin K deficiency

A

FFP

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9
Q

Massive transfusions

A

FFP

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10
Q

Thrombocytopenia

A

Platelets

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11
Q

ITP

A

Platelets

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12
Q

Volume expander

A

Plasma

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13
Q

Hemophilia A

A

Cryoprecipitate

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14
Q

Factor XIII deficiency

A

Cryoprecipitate

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15
Q

Hypofibrinogenemia

A

Cryoprecipitate

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16
Q

Neutropenia

A

Granulocytes

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17
Q

Sepsis

A

Granulocytes

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18
Q

Separated from WB by centrifugation or sedimentation any time before expiration date of WB, or collected by apheresis.

A

RBCs

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19
Q

Additive solution added to RBCs following removal of most plasma.

A

RBCs adenine, saline added

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20
Q

Frozen in glycerol within 6 days of collection.

A

RBCs frozen

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21
Q

High glycerol (40%) method most commonly used.

A

RBCs frozen

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22
Q

RBCs washed with saline.

A

Washed RBCs

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23
Q

Filtration or apheresis processing.

A

RBCs leukocytes reduced

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24
Q

Irradiation at 2,500 cGy.

A

RBCs irradiated

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25
Plasma separated from WB & frozen within 8 hr of collection
Fresh frozen plasma (FFP)
26
Prepared by thawing FFP at 1°–6°C, removing plasma, & refreezing within 1 hr
Cryoprecipitate
27
Centrifugation of WB at RT within 8 hrof collection.
Platelets
28
Apheresis.
Apheresis platelets
29
WBCs removed by filtration or during apheresis processing.
Leukocytereduced platelets
30
4–6 ABO-identical plt pooled using closed system.
Pre storage pooled platelets
31
1°–6°C
RBCs RBCs adenine, saline added Washed RBCs RBCs leukocytes reduced RBCs irradiated
32
Frozen in high glycerol: ≤65°C.
RBCs frozen
33
After deglyc (washing in decreased concentration of saline): 1°6°C
RBCs frozen
34
Frozen: ≤-18°C.
Fresh frozen plasma (FFP) Cryoprecipitate
35
After thawing: 1°-6°C
Fresh frozen plasma (FFP)
36
After thawing: RT
Cryoprecipitate
37
20°–24°C
Platelets Apheresis platelets Leukocytereduced platelets Pre storage pooled platelets
38
35 days in CPDA-1
RBCs
39
42 days
RBCs adenine, saline added
40
Frozen: 10 yr.
RBCs frozen
41
After degylc: 24 hr (unless closed system used)
RBCs frozen
42
24 hr after washing
Washed RBCs
43
Closed system: same as RBCs.
RBCs leukocytes reduced
44
Open system: 24 hr
RBCs leukocytes reduced
45
Original outdate or 28 days from irradiation, whichever comes 1st
RBCs irradiated
46
Frozen: 12 mo.
Fresh frozen plasma (FFP) Cryoprecipitate
47
After thawing: 24 hr
Fresh frozen plasma (FFP)
48
After thawing: single units 6 hr, pools 6 hr if sterile connecting device used, other- wise 4 hr
Cryoprecipitate
49
5 days from collection with agitation.
Platelets Apheresis platelets
50
After pooling, 4 hr
Platelets
51
Open system—4 hr.
Leukocytereduced platelets
52
Apheresis— 5 days
Leukocytereduced platelets
53
5 days from collection
Pre storage pooled platelets
54
Inadequate tissue oxygenation
RBCs
55
Same
RBCs adenine, saline added RBCs frozen Apheresis platelets Pre storage pooled platelets
56
History of severe allergic rxn (e.g., IgA, other plasma proteins)
Washed RBCs
57
History of febrile rxn
RBCs leukocytes reduced
58
Immunodeficiency, malignancy, bone marrow transplant, tf with blood from blood relative, intrauterine & neonatal tf
RBCs irradiated
59
Deficiency of coag factors
Fresh frozen plasma (FFP)
60
Fibrinogen & factor XIII deficiencies
Cryoprecipitate
61
Severe thrombocytopeniaor abnormal platelet function
Platelets
62
Recurrent febrile rxn & to decrease risk of CMV transmission or HLA alloimmunization
Leukocytereduced platelets
63
Should have HCT ≤80%; otherwise not enough preservative to support RBCs.
RBCs
64
1 unit should increase HGB 1 g/dL or HCT 3%.
RBCs
65
Most commonly used RBC product.
RBCs adenine, saline added
66
Osmolality to monitor glycerol removal.
RBCs frozen
67
Virtually all plasma, anticoagulant, WBCs, & platelets removed.
RBCs frozen
68
Safe for IgAdeficient pt.
RBCs frozen
69
Used to store rare cells.
RBCs frozen
70
Not a substitute for leuko- reduced RBCs.
Washed RBCs
71
About 20% of RBCs lost in process.
Washed RBCs
72
Must retain 70- 85% of original RBCs. <5 × 106 WBCs.
RBCs leukocytes reduced
73
For prevention of graft-vs.-host disease.
RBCs irradiated
74
Kills donor T cells.
RBCs irradiated
75
Contains all coag factors.
Fresh frozen plasma (FFP)
76
Check for evidence of thawing & refreezing.
Fresh frozen plasma (FFP)
77
Thawed at 30°–37°C or by FDA-approved microwave.
Fresh frozen plasma (FFP)
78
Used for hemophilia A & von Willebrand disease only if factor VIII concentrate or recombinant factor preparations not available.
Cryoprecipitate
79
Should contain ≥80 IU of factor VIII & ≥150 mg of fibrinogen.
Cryoprecipitate
80
40–70 mL plasma.
Platelets
81
pH ≥6.2.
Platelets
82
1 unit should increase pltby 5,000–10,000/μL in 75-kg recipient.
Platelets
83
Shouldn’t be used if visible aggregates present.
Platelets
84
May contain residual RBCs.
Platelets
85
Usually pooled (4–6 units).
Platelets
86
≥5.5 ×1010 plt.
Platelets
87
≥3.0 ×1011 plt.
Apheresis platelets
88
Equiva-lent to 4–6 units.
Apheresis platelets
89
Exposes recipient to fewer donors.
Apheresis platelets
90
Extended outdate over-comes need for tfservice to pool just before administration.
Pre storage pooled platelets
91
1st soft spin yields platelet-rich plasma. 2nd hard spin separates pltfrom plasma.
Platelets

Immunohematology Lec (35 decks)

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