Ch 9- Alterations in Immunity and Inflammation

Question 1

Addison’s disease, Myasthenia Gravis, Chron’s disease, and Hemolytic Anemia are all types of what immunity?

Answer 1

Autoimmunity

Question 2

Explain what occurs in the immune response of Raynaud’s phenomenon.

Answer 2

Immune complexes in Raynaud’s are temperature-dependent. When a patient has below-normal body temperature, these immune complexes precipitate in the blood, and are deposited into peripheral tissues (fingers, toes, nose), blocking circulation and causing symptoms of pallor, numbness, and cyanosis. It is a Type III hypersensitivity.

Question 3

Name some examples of Type IV hypersensitivity reactions.

Answer 3

Graft rejection, contact allergies to poison ivy or metals, TB skin test.

Question 4

What mechanism is involved in a Type IV hypersensitivity reaction?

Answer 4

Type IV is cell-mediated (by T cells), and does not involve antibodies. T cells attack and destroy cellular targets, produce cytokines and activate phagocytic cells.

Question 5

Why can a patient with Type O blood donate to all blood types?

Answer 5

Because their red blood cells have no A or B antigens.

Question 6

When a child accidentally scrapes his knee during a fall, histamine is released and binds to ____ to cause signs and symptoms of inflammation.

Answer 6

H1 receptors

Question 7

What type of hypersensitivity is associated with allergy, anaphalaxis, and asthma?

Answer 7

Type I

Question 8

What type of hypersensitivity is associated with drug-induced hemolysis and mismatched blood transfusion hemolysis ?

Answer 8

Type II

Question 9

What type of hypersensitivity is associated with serum sickness, SLE (systemic lupus erythematosus) and Arthus rxn?

Answer 9

Type III

Question 10

What type of hypersensitivity is associated with IgG/IgM monomer mediators?

Answer 10

Type II (Cytotoxic type)

Question 11

What type of hypersensitivity is associated with T cells?

Answer 11

Type VI (Delayed type)

Question 12

What type of hypersensitivity is associated with IgE mediators?

Answer 12

Type I ( Intermediate Type)

Question 13

What type of hypersensitivity is associated with PPD rxn, contact dermatitis?

Answer 13

Type IV

Question 14

What type of hypersensitivity is associated with IgG/IgM multimer mediators?

Answer 14

Type III (Immune Complex Type)

Question 15

Type II hypersensitivity is cytotoxic or ___________ driven.

Answer 15

antibody