Ch. 18 Gene Mutations and DNA Repair Flashcards
What type of mutation affects the parent but no offspring?
somatic
What type of mutation affects half the offspring but not the parent?
germ-line
What type of mutation changes one codon?
substitution
What type of mutation affects more than one codon?
frameshift
What are the two types of frameshift mutations?
insertion and deletion
What are the two types of substitution mutation?
transition and transversion
Changing a purine to a purine or a pyrimidine to a pyrimidine
transition
Changing a purine to a pyrimidine or vice versa
transversion
Are transitions or transversions more likely to occur?
transition
What results in an accumulation of repeats over time due to strand slippage?
expanding nucleotide repeats
One amino acid changes to another
missense
Polypeptide chain stops prematurely
nonsense
The codon changes but the amino acid does not
silent
A positively charges amino acid is changed out for another positively charged amino acid
neutral
Complete or partial absence of normal protein function
loss of function