case 8 - prostate cancer Flashcards
what is the function and features of the prostate gland
walnut sized gland located behind the base of the penis, infront of the rectum and below the bladder
Surrounds the urethra
Primary function; produce seminal fluid, the liquid in semen that protects, supports and helps transport sperm
what are the risk factors for prostate cancer
age
Race
Family history
Nationality
Genetics - BRACA1 and 2
Diet, exercise, obesity
1 in 8 men in the UK are diagnosed with prostate cancer
what are the lower urinary tract symptoms for prostate cancer
Obstructive - feel like they can’t empty the bladder etc
Irritative - frequency, discomfort or blood in urine
what are the other symptoms of prostate cancer
metastatic
Pain etc
systemic
Fatigue, weight loss
how is prostate cancer diagnosed
history
DRE
PSA - first three are done in primary care
Multi parametric MRI
Biopsy
when does PSA increase
benign prostatic hypertrophy
Age
Prostatitis
Ejaculation
DRE
when does PSA decrease
drugs - finasteride, dutasteride
Obesity
Herbal preparations
what can screening lead to
Overdiagnosis
Over treatment
consider targeted PSA screening in high risk populations
what are the MRI techniques used
T1 & T2 images
Functional imaging
Dynamic contract enhanced DCE
Diffuse weighted imaging DWI
what are the prostate biopsies used
transrectal ultrasound guided TRUS biopsy
Biopsy taken through the rectal wall under ultrasound guidance
About 12 samples taken
template biopsy
Transperineal
Multiple samples taken
what is the score system used for prostate cancer and what does this tell us
Gleason score - used for prostate cancer
Grading system used to define aggressiveness
Score of 3-5 are considered cancerous
Addition of 2 most common scores = Gleason score
Lowest is 6 and highest Is 10
what is stage 1
cancer confined to prostate T1a-2a
PSA <10
Grade group 1 = 3+3=6
what is stage 2
*Stage IIA
–T1a-2a
–PSA 10-20
–Grade group 2
*Stage IIB
–T1-2
–PSA <20
–Grade group 2
*Stage IIC
–T1-2
–PSA <20
–Grade group 3-4
what is stage 3
*Stage IIIA
–T1-2
–PSA >20
–Grade group 1-4
*Stage IIIB
–T3-4
–Grade group 1-4
*Stage IIIC
–Grade group 5 = 10
what is stage 4
Stage IV prostate cancer - means cancers that have metastasised
- most common place for prostate cancer spread is lymph nodes and bones