Case 3 - clinical overview of disease of the pancreas Flashcards
what are non specific symptoms of GI discomfort
indigestion
fullness
bloating
nausea
pain
what are the intermittent severe indigestion differentials
gastro-oesophageal reflux disease
Peptic ulceration
Biliary stone disease
Inflammatory bowel disease
Pancreatic disease
what are the dimensions of the pancreas
14-20cm and weighs 100g
how does the pancreas sit in the body
anteriorly faces the lesser sac
the head borders the confluence of SMV and PV
body left border of SMV and the aorta
tail the left border of the aorta to the splenic hilum
what is the SMV
superior mesenteric vein
what is the PV
portal vein
what is the endocrine function of the pancreas
20% by mass
islet cells secrete hormones
blood glucose homeostasis
what is the exocrine function of the pancreas
80% by mass
digestive enzymes
acid buffering
released into duodenum
what reflex is initiated by food ingestion
gastro-colic reflex
what is released into the stomach as a response to food
gastrin leads to HCL and pepsinogen
what is released to act on the pancreas
secretin is released from intestinal mucosa to act on the pancreas
what does secretin do
decreases acid release and gastric motility
what does CCK do
acts on pancreas –> lipase and acts on GB for contractions
what are the positive feedback controls of the exocrine pancreas
ach
VIP
GRP
CCK
secretin
what are the negative feedback controls of the exocrine pancreas
somatostatin
pancreatic polypeptides
what enzymes does the exocrine pancreas produce to facilitate digestion
Lipase
Proteases
Amylase
Nucleases
where are these enzymes released
into the duodenum
what does hydrolysis require presence of
bile acids for emulsification
what does pancreatic lipase do
turns triglyceride into monoglyceride and free fatty acids
what is the pro enzyme involved in protein digestion and where is it stored
chymo-tripsin
what happens to trypsinogen
activated by duodenal enterokinase to trypsin
what does trypsin do
activates pro enzymes