case 6 - diabetes review Flashcards
what is the WHO diagnosis for diabetes in the fasting state
normal: fasting; less than 6.1mmol/L
Impaired fasting glycaemia: 6.1-6.9mmol/L
Diabetes: greater than 7mmol/L
what is the WHO diagnosis for diabetes 24 hours post prandial
impaired glucose tolerance: greater than 7.8-11mmol/L
Diabetes: greater than 11 mmol/L
what is the value of HbA1c that confirms type 2
HbA1c greater than 48mmol/mol
describe the physiology of the beta cells
islet: beta cells
pancreatic beta cells express GLUT2 glucose transporters, which permit rapid glucose uptake regardless of the extracellular sugar concentration
what happens in type 1 diabetes
beta cells get destroyed which leads to no or very little insulin produced
what are the effects of insulin on the liver
increased glucose uptake and glycogen synthesis
what are the effects of insulin on the muscle
increased glucose uptake and glycogen synthesis
what are the effects of insulin on adipose tissue
increased glucose uptake and storage as fat
decreased breakdown to fatty acids
what are the effects of insulin on blood
glucose levels fall
what are the effects of lack of insulin on the liver
decreased glucose uptake
Increased glycogen breakdown and gluconeogenesis
Conversion of fatty acids to ketone bodies
what are the effects of lack of insulin on the muscle
decreased glucose uptake via GLUT4
what are the effects of lack of insulin on adipose
decreased glucose uptake and storage
increased breakdown of fat and release of fatty acids
what are the effects of lack of insulin in the blood
glucose levels rise
what are the pathophysiology steps of diabetes;
low utilisation of glucose and increased endogenous production of glucose by the liver
hyperglycaemia
loss of glucose in the urine
increased urination - polyuria, nocturia
dehydration - increased thirst-polydipsia
what happens when there is loss of glucose in the urine
osmotic drag of glucose on water
water and glucose lost in urine
electrolytes lost along with water
what are the specific tests used to diagnose type 1 diabetes - there are 5
GAD65 antibodies - around 80% at diagnosis
Islet cell antibodies - around 69-90% at diagnosis
ZnT8 antibodies
Insulin antibodies (IAA)
C-peptide/insulin/glucose levels
what are markers of beta cell autoimmunity in type 1 diabetes
autoantibodies
islet cell antibodies (ICA, against cytoplasmic proteins in the beta cell), antibodies to glutamic acid decarboxylase (GAD-65), insulin autoantibodies (IAA), and IA-2A, to protein tyrosine phosphatase
Autoantibodies against GAD 65 are found in 80% of patients with type 1 diabetes at clinical presentation
Presence of ICA and IA-2A at diagnosis for type 1 diabetes range from 69-90% and 54-75%, respectively
what does IAA prevalence correlate with
correlates inversely with age at onset of diabetes; it is usually the first marker in young children at risk for diabetes and found in approximately 70% of young children at the time of diagnosis
what are the features of type 2 diabetes
due to insulin resistance
less acute onset compared to type one
progressive decline in beta cell function