Case 2 - medications Flashcards
what is amoxicillin
is a penicillin derivative used for the treatment of infections caused by gram positive bacteria
what is amoxicillin commonly used in combination with for the treatment of H pylori
omeprazole
what is the mechanism of action of amoxicillin
competitively inhibits penicillin-binding protein 1
Penicillin bind proteins are responsible for glycotransferase and transpeptidase reactions that lead to cross-linking of D-alanine and D-aspartic acid in bacterial cell walls
Helicobactor pylori is an inhibitor - penicillin binding protein
Amoxicillin competitively inhibits penicillin binding proteins, leading to up regulation of autolytic enzymes and inhibition of cell wall synthesis
what is clarithromycin
a macrolide antibiotic used for the treatment of a wide variety of bacterial infections
what is clarithromycin derived orm
erythromycin
what is the mechanism of action of clarithromycin
it inhibits bacterial synthesis by binding to the bacterial 505 ribosomal subunit
binding inhibits peptifyl transferase activity and interferes with amino acid translocation
what is another combination of drugs that can be used to treat h pylori
H.pylori infection can also be treated using a combination of clarithromycin, vonoprazan and amoxicillin