Case 3 - alcohol use - clinical perspective Flashcards

1
Q

how many deaths a year worldwide

A

3 million

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2
Q

it is the ….. leading cause of death

A

7th

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3
Q

when is the peak incidence

A

35-54

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4
Q

what percentage receive treatment in the UK

A

only 18%

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5
Q

what is the prevalence of alcohol dependence in the uk

A

1.3% prevalence

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6
Q

alcohol use disorder is categoried by which model

A

DSM-5

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7
Q

alcohol dependence is categorised by

A

ICD-10 and DSM-IV

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8
Q

what is dipsomania

A

alcoholism, specifically in a form characterized by intermittent bouts of craving for alcohol

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9
Q

what is potomania

A

It is described as the excessive intake of alcohol, particularly beer, together with poor dietary solute intake that leads to fatigue, dizziness, and muscular weakness.

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10
Q

what is potomania a unique syndrome of

A

hyponatremia

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11
Q

diagnosis criteria using ICD-11 for alcohol dependence

A

disorder of regulation of alcohol use
Repeated or continuous use of alcohol
Strong internal drive to use alcohol
Present for 12 months or 1 month if continuous

internal drive, compulsion, desire, urge or craving to use alcohol
Impaired control
Prioritisation of alcohol over other activities
Persistent use despite harms

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12
Q

what are two examples of neuroadaption in alcohol dependence

A

tolerance

withdrawal of symptoms and use of alcohol to alleviate withdrawal

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13
Q

what is the CAGE questionnaire

A

C: have you ever felt that you needed to cut down on your drinking

A: have people annoyed you by criticising your drinking

G: have you ever felt guilty about drinking

E: have you ever felt that you need a drink first thing I the morning to steady your nerves or get rid of a hangover

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14
Q

what is the gold standard screening tool for alcohol

A

AUDIT screening tool: FAST version

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15
Q

what is FAST

A

it is an alcohol assessment harm tool. it consists of a subset of questions from the full alcohol use disorders, identification test AUDIT

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16
Q

what was FAST developed for

A

developed for use in emergency departments, but it can be used in a variety of settings

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17
Q

what is the first question of the FAST questionnaire

A

how often have you had 6 or more units if female and 8 or more if male in a single occasion in the last year?

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18
Q

what happens if the answer is monthly or weekly

A

if monthly, answer the following questions, if weekly stop here

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19
Q

what are the UK guidelines for safe drinking

A

14 units per weeks
spread use over three days if drinking 14 units a week

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20
Q

what does one unit of alcohol equal

A

10ml or 8g of pure alcohol

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21
Q

what is binge drinking for men

A

over eight units

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22
Q

what is binge drinking for women

A

over six units

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23
Q

what is frequent binge drinking between age 18-25 associated with

A

with 2-3 times increased risk of alcohol dependence between the ages of 25-45

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24
Q

how many calories are in a gram of pure alcohol

A

7.1

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25
Q

what are the effects of alcohol on the oesophagus

A

carcinoma of oesophagus, especially squamous carcinoma
Oesophageal varices, associated with chronic liver disease - watch out for Hb drops, raised urea, coffee ground vomit

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26
Q

what are the effects of alcohol on the stomach

A

acute gastritis
Acute ulceration
Chronic peptic ulceration
Portal gastropathy

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27
Q

what is the indirect effect of alcohol related liver disease

A

indirect metabolite effect e.g acetaldehyde

28
Q

what is there activation of in alcohol related liver disease

A

activation of free radicals

29
Q

what systems are induced in alcohol related liver disease

A

induction of enzyme systems especially cytochrome p450

30
Q

what is the usual vitamin deficient in alcohol related liver disease

A

B group

31
Q

what are the symptoms of acute pancreatitis

A

severe abdominal pain
Radiating to the back
Nausea and vomiting

32
Q

what is there elevation of in acute pancreatitis

A

serum amylase

33
Q

what are symptoms of chronic pancreatiits

A

intermittent severe upper abdominal and back pain
Weight loss

34
Q

what is exocrine tissue replaced by in chronic pancreatitis

A

fibrosis

35
Q

what does this lea to

A

pancreatic malabsoption - steatorrhoea and reduced vitamins

36
Q

what vitamins are reduced

A

A,D,E,K

37
Q

what percentage of heavy drinkers go on to progress to alcoholic hepatitis or cirrhosis

A

10-20%

38
Q

what does obesity do to the risk of alcoholic liver disease

A

doubles the risk

39
Q

are each of these reversible or irreversible symptoms of alcoholic liver disease:

acute fatty change
hepatic fibrosis
cirrhosis
hepatic decompression
acute alcoholic hepatitis

A

acute fatty change - reversible
Hepatic fibrosis - reversible
Cirrhosis - irreversible
Hepatic decompression - fatal
Acute alcoholic hepatitis - reversible

40
Q

what are the effects of alcohol on the cardiac system

A

atrial fibrillation
Myocardial infarction
Congestive heart failure
Cardiomyopathy

41
Q

what is Delirium Tremens

A

delirium with hallucinations and autonomic disturbances in alcohol withdrawal

42
Q

what is Wernicke’s encephalopathy

A

acute - delirium, ataxia and ophthalmoplegia - glutamatergic overdrive

43
Q

what is Korsakoff’s psychosis

A

chronic - triad of short term memory loss, confabulation and ataxia

44
Q

what are both these conditions secondary to

A

to effects of alcohol and B1(thiamine) deficiency

45
Q

what kind of polyneuropathy in particular is seen in alcohol dependence

A

stocking fashion

46
Q

what is polyneuropathy usually secondary to

A

Secondary to thiamine and other b vitamin deficiency e.g B12 (cobalamin)

47
Q

when are seizures present

A

in early withdrawal

48
Q

when are DT’s present

A

later on

49
Q

what is altered brain function attributed to

A

imbalance of excitatory and inhibition neurotransmission

50
Q

what does decrease GABAa receptor function lead to

A

increased seizure susceptibility, increased anxiety and altered sensitivity to alcohol cues

51
Q

what does increased NMDA receptor function lead to

A

increased seizure susceptibility, increased neurotoxicity and altered senstivity to alcohol cues

52
Q

what does increased voltage operated Ca2+ channel function lead to

A

increased seizure susceptibility, increased neurotoxicity

53
Q

what do you give if there is a decrease in GABAa function

A

you give benzodiazepines

54
Q

what do you give if there is an increase in NMDA function

A

thiamine or pabrinex

55
Q

what do you give if there is an increase in Ca2+ channel activity

A

you give acamprosate

56
Q

where does myopathy typically affect

A

proximal muscles in the pelvic girdle

57
Q

what is the major blood disorder usually found in alcohol abuse

A

thrombocytopenia and bleeding;
usually present with low platelets

58
Q

what is the relationship between alcohol and bone marrow

A

alcohol is toxic to bone marrow, leads to reduced normal cell levels

59
Q

what does the effect on the liver lead to

A

folate deficiency and other effects on RBCs

60
Q

what can all of this leaf to

A

pancytopenia

61
Q

list step by step, alcohol metabolism

A

ethanol is metabolised by alcohol dehydrogenase to acetaldehyde

then acetaldehyde is metabolised by aldehyde dehydrogenase to acetate

62
Q

why do we prescribe disulfiram

A

it stops the action of aldehyde dehydrogenase from metabolising acetaldehyde into acetate

63
Q

what should one do to reduce harm reduction in alcohol dependence

A

drink diary
Look at trigger points - consider changes to behaviour
Swap to lower strength alcohol
Low strength wine is available
if dependent people present and cannot under an inpatient or community detox then they should continue drinking - aim to drink at a level that prevents withdrawal symptoms
Unsupervised detox has a mortality of >10%
refer/signpost to drug and alcohol services

64
Q

what is the RADAR pathway in greater manchester

A

rapid access detox for alcohol dependent people requesting a detox in any A&E in manchester

65
Q

how long is the medically supervised detox in the RADAR pathway

A

5-7 days

66
Q

list the safe alcohol advice

A

alway have at least 4 consecutive days alcohol free
Try to avoid/minimise heavy sessions back to back
Try to avoid/minimise long drinking sessions
Eat a heavy meal before potential session at least 1-2 hours before - most alcohol is absorbed through the small intestine
Stay well hydrated and have more food early in the night when out

Substitute in non-alcoholic or lower alcohol options
Memory loss is a bad sign - avoid
Sometimes some people shouldn’t drink
Think about content and where you are at mentally and physically
Self care