Case 3 - alcohol Flashcards
how is alcohol absorbed
absorbed form the upper small intestine via the portal vein and is then transported to the liver
what is some alcohol in the stomach metabolised by
alcohol dehydrogenase
why is womens safe limit less than men
they have a lack of alcohol dehydrogenase
where is the rest of alcohol metabolised
the liver
what happens in the liver to this alcohol
converted to acetaldehyde and excreted by conversion to carbon dioxide in citric acid cycle
what enzyme is involved in the metabolism of alcohol in the liver
cytochrome p4502E1
what is alcohol at low levels
a stimulant
what happens if there is chronic use of alcohol
it has depressant effects on the CNS , mainly depression of cardiovascular and repsiratory centres in the brainstem
at low doses, what does alcohol protect against
atheromas
what is Wernicke’s encephalopathy
decreased thiamine effects mammiliary bodies in the brain
what is induced in alcohol related disease mechanisms
induction of enzyme systems, especially cytochrome p450
what is the biggest nutrient deficiency
vitamin B
what is the early change in alcohol liver disease
acute fatty change
which area does this acute fatty change usually affect
predominantly acinar zone 3 - this area is furthest away from a blood supply
features of acute fatty change
Mainly large droplet
May cause acute hepatic failure
Reversible on withdrawal of alcohol