Cardio Embryology Flashcards

1
Q

Where is the heart formed?

A

In the carcinogenic field

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2
Q

How is the heart formed?

A

By the coalescing of my oblasts and blood islands

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3
Q

The heart is formed by?

A

Visceral mesoderm

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4
Q

Where is the cardiogenic field located?

A

At the very cranial end in between endoderm and splanchnic mesoderm layer

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5
Q

How does folding of the ‘heart tube’ occur?

A

Lateral folding bring the edges of the shape together in the midline to form a tube and the myocardium develops around it

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6
Q

Once myocardial cells have differentiated they will start to?

A

Beat

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7
Q

What occurs simultaneous to lateral folding?

A

Cranio-caudal folding

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8
Q

Cranio-caudal folding brings the heart?

A

Into its final position

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9
Q

What happens on day 23?

A

Heart begins to fold and loop
Atrium moves dorsal and cranial
Ventricle is displaced left
Bulbus cordis (inferiorly, ventrally to the right)

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10
Q

How are the ends of the heart tube anchored at each end?

A

One by the differentiating arterial turns

Other by venous channels (fixed to atrium)

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11
Q

The common atrioventricular canal is partitioned by the simultaneous proliferation of?

A

The endocardial cousins, muscular interventricular septum and intertribal septum

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12
Q

How is the foramen ovale formed?

A

Septum secundum draping over opening in the septum premium

Forms a membranous valve

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13
Q

What separates the aorta and pulmonary trunk?

A

Bifurcation of the trunucsarteriosus

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14
Q

The 4th aortic arch gives rise to the?

A

Aorta

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15
Q

The 6th aortic arch is the origin of the?

A

Pulmonary artery

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16
Q

How does obliteration of the inter ventricular foramen occur?

A

By masses of endocardial tissues form the ventricular septum, the endocardial cushions and spiral aortic septum

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17
Q

While the ductus arterioles is patent the majority of blood continues into the ______ via the ductus arterioles due to?

A

Descending aorta

High resistance to flow in the collapsed lungs

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18
Q

Oxygenated blood from placenta enter the right atrium via the ___ and tends to pass through the foramen ovale directly into the ____ – ____– ____ – aorta – ______ and other tissues + ______ to the brain

A
IVC
LA 
LV
Descending
Carotid
19
Q

Once the baby is delivered the lungs inflate and the resistance to flow decreases. What happens to the ductus arterioles then?

A

Shifts entire right ventricular output to the pulmonary circulation and oxygenated blood from the lung is distributed systemically when the pressure in the LA > RA the valvula is pressed over the foramen ovale (Partitioning of heart is functionally complete)

20
Q

During vascular development all the vessels are?

21
Q

The 6 pairs of aortic arches are associated with?

A

Pahryngeal arches

22
Q

Outline aortic arches 1&2?

A

Mostly obliterated

Associated with maxillary and stapedial artery

23
Q

Aortic arch 3 gives rise to?

A

Common carotid arteries

24
Q

Aortic arch 4 gives rise to?

A

Right subclavian artery ü part of aortic arch + part of aortic arch on left side

25
Aortic arch 5 is?
Rudimentary or absent
26
Aortic arch 6?
Sprotus branches that form pulmonary arteries and ductus anteriosus on the left
27
The vitteline veins drain the? | Give rise to?
Drain yolk face | Portal venous system draining gut, hepatic sinusoids and gut, hepatic portion of IVC
28
The umbilical veins carry? Will give rise to?
Oxygenated blood from placenta | Right vein degenerates, elf remains as definitive umbilical vein
29
The cardinal veins give rise to?
Systemic veins
30
The anterior cardinal veins drain? Later on drain?
Head and neck | Jugular system + left brachiocephalic veins + SVC
31
The posterior cardinal veins drain?
The trunk (azygous, hemiazygous, gonadal and renal, iliac and IVC)
32
What are functions of the placenta?
``` Fetal homeostasis Gas exchange Acid-base balance Nutrient transort to foetus Waste product transport from foetus Hormone production IgG transport PGE2 ```
33
The foetal heart pumps blood to the placenta via the?
Umbilical arteries
34
Blood returns from the placenta to the heart via the?
Umbilical vein
35
What connects the umbilical vein to the IVC?
Ductus venosus
36
Which opening in the atrial septum connects the right and left atrium allowing blood to flow through?
Foramen ovale
37
What connects the pulmonary bifurcation to the ascending aorta?
Ductus Arteriosus
38
What maintains the potency of the ductus arterioles during pregnancy?
Circulating PGE2 produced by the placenta
39
PGE2 is antagonised by?
NSAIDS - don't use in pregnancy
40
When does the ductus arteriosus close?
Functionally with nhrs-days | Anatomically within 7-10 days due to increased pO2 and decreased flow and decreased PGE2
41
PGE2 is metabolised in the?
Lungs
42
The ductus arteriosus becomes a?
Fibrous ligament
43
Failure of pulmonary resistance to adapt causes?
PPHN (Persistent pulmonary hypertension of the newborn)