Brucella Flashcards
Overview of Brucella!
Gram neg
Aerobic
Non spore coccobacilli (very short)
LOVE CO2 (capnophilic)
Intracellular
Agent of regulatory concern
ZOONOTIC
PERSISTENT INFECTION!!
Name some brucella and what species they infect
Abortus- cattle
Melitensis - sheep and goats
Ovis - sheep
Suis- swine
Canis - dogs
Pinnipedialis - seals
None in birds!
What is special about B melitensis
It i eradicated in the states but still found in other parts of the world
What are the 2 varieties of brucella
Rough and smooth
Smooth has O antigen polysaccharides
Rough only has 1 core polysaccharides (antigen is not complete!)
Which kind of O polysaccharide has more virulence and why?
Virulence is determined partly by presence of LPS. Complete O has more virulence
_____ and ____ and ____ are smooth brucella
Abortus, melitensis, and suis
Who’s the rough brucella!
Canis and ovis
How is brucella transmitted
Carrier animals and allllll the sex juices!!!
Sexual contact, placenta, birthing fluids, aborted feti, milk, blood, urine, and mucous membrane contact.
*sometimes slaughter house worked get it because of the contamination)
Why does brucella result in persistent infections
They’re intracellualr pathogens they replicate in epithelial, endothelial, and dendritic cells. Also in the macrophages/monocytes and microglia. Leading to pyogranulomatous infection
Why does brucella concentrate in placentas
They like erythritol (which is found in high concentrations in placentas)
How does brucella enter mammalian cells
Through the zipper mechanism. The T4SS are involved in directing the process in the ER, helping them to invade the ER
What are the hosts, disease and incidental hosts of B. Abortus
Cattle & bison.
Cause abortion, or hit is, and epididymitis.
Sheep, goats, pigs get sporadic abortions
Horses get bursitis (fistulous withers, and poll evil)
Humans, dogs, and cats, get intermittent fever (undulant fever), and systemic disease
Name the natural host the disease and the occasional host for melitensis
Goats, sheep have abortions, or hit is, and arthritis
Cattle have sporadic abortion
Humans have severe fever and systemic disease
Pigs that have abortions, or hit is, arthritis, and spondylitis, and infertility are suffering from_________
Humans and dogs that have intermittent fever and systemic disease are also suffering from this species of brucella
Suis
B ovis has who as their natural host causing what disease and who are their occasional host
Sheep and they cause epididymitis and sporadic abortions.
It does not seem to infect humans
Name the species of brucella that causes abortions, epididymitis, and diskospondylitis and infertility in dogs. But only causes mild systemic disease in humans
Canis
Which species is called Bangs disease
Abortus
Where does Abortus shed in a bull and how long does it shed
The bull will become infertile and the brucella will shed in the semen for the rest of the bulls life
Where does Abortus localise in the cow
The spleen
What is the path of Abortus in a pregnant cow during the first pregnancy
The first pregnancy usually results in abortions. The bacteria is present in the foetus, placenta, foetal fluid and uterine. And all the other cows in the field come and sniff sniff and possibly get infected
What happens in the second or subsequent pregnancies with brucella
No abortions but Abortus will shed at parturition
Will brucella shed through the mammary gland
Yes but only intermittently
When does brucellosis tend to cause abortions
Late-term
What is poll-evil
It is septic arthritis of the atlanto-occipital joint
