Brain Damage Flashcards
edema
accumulation of fluid (swelling) can cause pressure on brain areas and compromises function to lead to further damage and further strokes
lacunar stroke
ischemic stroke type, caused by blocks of small, penetrating end-branches
stenosis
abnormal narrowing of a blood vessel
tPA
tissue plaminogen activator - the clot-buster, restores blood flow
solitaire catheter device
removes the clot itself
decorticate response to pain
abnormal flexion to painful stimuli
decerebrate response to pain
extension to painful stimuli (more severe damage than decorticate response)
mTBI mild TBI
concussion
mild TBI classification system
LOC < 30, PTA < 24h
moderate TBI classification system
LOC > 30, PTA >24h
PTA
post traumatic amnesia
LOC
loss of consciousness
what is TBI defined by? symptoms?
NO by course
PCS
post concussion syndrome, 1-10% of population present symptoms greater than one year post-injury, but its not specific to concussion or a syndrome (could be due to depression), requires validity measures
severe TBI GCS score
< 9
moderate TBI GCS score
9-12
minor TBI GCS score
> =13
what are 5 common stroke mechanisms?
ischemic:
1) atherosclerosis ischemic (thrombotic stroke)
2) blood clots travel from larger to smaller vessel (embolic stroke)
3) small penetrating end-branches block (lacunar stroke)
hemorrhagic:
4) small aneurysms on penetrating end-arteries or AVM’s leak into brain (intra-cerebral hemorrhagic stroke)
5) large congenital Berry aneurysm of Circle of Willis vessels rupture (sub-arachnoid hemorrhage)
thrombosis
blockage of vessel
embolism
clot breaks off and circulates-forms a blockage as the vessel narrows
transient ischemic attacks (TIA’s)
episode of vascular insufficiency that causes a temporary loss of brain function with total recovery within 24 hours, due to small atheroemboli that subsequently dissolve
secondary prevention
after TIA or stroke
acute treatment of stroke
tPA (clot buster)
risk factors for stroke
- hypertension (lack of elasticity in vessels)
- hyperlipidemia
- diabetes
- atrial fibrillation
- ischemic heart disease
- BP/metabolic syndrome
- alcoholic heart disease
- cigarette smoking
toxins
substances can be toxic to cells and cause cell-death (e.g. CO, illicit drugs, alcohol)