Bovine Tuberculosis Flashcards

1
Q

Giant cells typically occur in tubercles

A

T

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2
Q

Mycobacterium tuberculosis can cause generalised tuberculosis in pigs

A

T

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3
Q

Mycobacterium tuberculosis can cause tuberculosis in humans

A

T

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4
Q

Facultative pathogenic mycobacteria can colonise only cold-blooded animals

A

F

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5
Q

Mycobacteria are facultative intracellular bacteria

A

T—obligate/faculative/saprophyte pathogenic—facultative intracellular

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6
Q

Saprophytic and facultative pathogenic mycobacteria cannot colonise warm blooded animals

A

F

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7
Q

Facultative pathogenic Mycobacteria can only reproduce in the environment

A

F

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8
Q

Facultative pathogenic Mycobacteria can only colonize in warm-blooded animals

A

F

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9
Q

There is no antigen connection between facultative and obligate pathogenic mycobacteria

A

F

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10
Q

Lympho-haematogenous spread of mycobacteria can be seen in the post primary phase of tuberculosis

A

F—-early generalisation

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11
Q

Lympho-haematogenous spread of mycobacteria can be seen in the post primary phase of tuberculosis.

A

1) F

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12
Q

There is a close antigen relationship between mycobacteria

A

T

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13
Q

Mycobacterium bovis can cause tuberculosis only in ruminants

A

F

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14
Q

Mycobacterium bovis can cause generalized tuberculosis in goats

A

T

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15
Q

Tuberculin is an extract made from broth culture of mycobacteria

A

T
PPD (purified protein derivate)
• tuberculoproteins
• M. bovis: 20.000 IU
• M. avium subsp. avium: 25.000 IU

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16
Q

The tuberculin contains antigens from mycobacteria

A

T

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17
Q

Tuberculin is the toxin produced by mycobacteria

A

F

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18
Q

Intra canalicular spread of mycobacteria can be seen in the post primary phase of tuberculosis

A

T

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19
Q

Antibodies against mycobacteria are detected in the tuberculin test

A

F

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20
Q

Facultative pathogenic mycobacteria can cause local lesions in pig

A

T

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21
Q

Facultative pathogenic mycobacteria cannot cause tuberculosis

A

F

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22
Q

Mycobacteria are acid and alcohol fast bacteria

A

T

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23
Q

Mycobacterium tuberculosis can cause generalized tuberculosis in parrots

A

T

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24
Q

Fresh tuberculosis lesions in the lymph nodes are common the early generation

A

T

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25
Q

Mycobacteria can be stained with Ziehl-Neelsen staining

A

T

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26
Q

Mycobacteria cannot be stained

A

F

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27
Q

Obligate pathogenic mycobacteria can occur and replicate in the environment

A

F

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28
Q

All mycobacteria species are obligate pathogenic

A

F

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29
Q

The resistance of mycobacteria is low, they die in the environment soon

A

F

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30
Q

Mycobacterium bovis can cause generalised tuberculosis in goats

A

T

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31
Q

Fresh tuberculosis lesions in the lymph nodes are common in the post primary phase

A

F—in early generalisation phase

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32
Q

Mycobacteria are highly resistant thanks to lipids and waxes in the cell wall

A

T

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33
Q

Pigs are resistant against Mycobacterium tuberculosis

A

F

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34
Q

Mycobacterium bovis can cause generalized tuberculosis in badgers

A

T

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35
Q

Mycobacterium caprae can infect only goats

A

F

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36
Q

Tuberculosis lesions in the lymph node are common in the early generalization

A

T

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37
Q

The habitat of the obligate pathogenic Mycobacteria is the environment

A

F

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38
Q

Mycobacteria are obligate intracellular bacteria

A

F faciultative

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39
Q

Waxes can be found in the cell wall of Mycobacteria

A

T

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40
Q

Only Mycobacterium tuberculosis can cause tuberculosis in humans

A

F

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41
Q

Neutrophil granulocytes can be typically found in tubercles

A

F—giant cells lymphocytes macrophages histiocytes

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42
Q

Necrosis can be seen in the tubercles

A

T

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43
Q

The habitat of saprophytic, facultative pathogenic Mycobacteria is the environment

A

T

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44
Q

Saprophytic, facultative pathogenic Mycobacteria cannot colonize mammals

A

F

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45
Q

The cell wall of mycobacteria contains mycolic acid

A

T

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46
Q

The tuberculin contains lipopolysaccharide (LPS) antigens

A

F

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47
Q

The cell wall of mycobacteria contains large amount of lipopolysaccharide

A

T

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48
Q

Mycobacteria can replicate only in animals

A

F

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49
Q

Mycobacterium tuberculosis causes tuberculosis in parrots

A

T

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50
Q

Mycobacterium tuberculosis causes generalized tuberculosis in badgers

A

T

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51
Q

Mycobacterium tuberculosis causes tuberculosis in poultry

A

F–mycobacterium avium

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52
Q

All mycobacteria can replicate in the environment

A

F–not all some are obligate pathogenic

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53
Q

Mycobacterium bovis can cause tuberculosis in wild living ruminants

A

T

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54
Q

Mycobacterium bovis can cause tuberculosis in wild boars

A

T

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55
Q

If the increase of the thickness of the skin fold in the tuberculin test is 1.9 mm the reaction is positive

A

F– more than 4mm=positive
less than 2mm is negative
2-4mm inconclusive

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56
Q

The skin intradermal tuberculin test is a Type IV. hypersensitivity reaction

A

T

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57
Q

Mycobacteria can survive in the environment only for a few days

A

F

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58
Q

Atypical mycobacteria can cause lesions in pigs

A

T

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59
Q

Mycobacteria caprae can infect cattle, other ruminants and swine

A

T

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60
Q

Saprophytic, facultative pathogenic mycobacteria cannot cause tuberculosis

A

F

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61
Q

Only cattle maintain bovine tuberculosis

A

F

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62
Q

Obligate pathogenic Mycobacteria can only reproduce in the infected body

A

T

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63
Q

Facultative pathogenic mycobacteria can cause tuberculosis in fishes

A

T

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64
Q

Mycobacteria are not resistant, they can survive in the environment for maximum of two days

A

F

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65
Q

Mycobacterium suis is the most frequent agent of tuberculosis of pigs

A

F

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66
Q

Facultative pathogenic mycobacteria can colonize the gut of pigs

A

T

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67
Q

Sometimes facultative pathogenic mycobacteria cause lesions in pig

A

T

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68
Q

Mycobacteria can survive in the environment

A

T

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69
Q

Mycobacteria cannot be cultured

A

F

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70
Q

Waxes and lipids in the mycobacteria are virulence factors

A

T

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71
Q

The agent of avian tuberculosis is an obligate pathogenic bacterium

A

T

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72
Q

Tuberculin test is an allergic test

A

T

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73
Q

Mycobacteria can be cultured, but their incubation time is long

A

T

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74
Q

Tuberculosis is diagnosed by detecting antibodies to M. bovis in the blood with ELISA

A

F–tuberculin test

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75
Q

The center of the tubercle is necrotized

A

T

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76
Q

The tubercle consists of histiocytes and foreign body giant cell.

A

T

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77
Q

The causative agents of tuberculosis are obligate pathogenic bacteria

A

T

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78
Q

Köster staining is a special staining for Mycobacteria

A

F—brucella

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79
Q

Mycobacteria are highly resistant

A

T

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80
Q

Early generalization of mycobacteria occurs via lympho-hematogenous route

A

T

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81
Q

In dogs’ tuberculosis can be generalized

A

T

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82
Q

Late generalization can be characterized by lost resistance

A

T

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83
Q

In the tubercle, coagulation necrosis is seen

A

T

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84
Q

In the phase of early generalization Mycobacteria do not replicate in the lymph node

A

F

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85
Q

Mycobacteria are a worldwide disease

A

T

86
Q

Chronic tuberculosis causes changes in the lymph node

A

F

87
Q

Mycobacteria can be demonstrated from the discharge of sick animals by staining

A

T

88
Q

Tuberculosis can be demonstrated earliest by ELISA

A

F

89
Q

Tuberculosis can first be diagnosed by PCR

A

F

90
Q

Tuberculosis can be diagnosed with certainty serology

A

F

91
Q

Mycobacterium infection in pigs can be zoonotic

A

T

92
Q

Mycobacterium spp. in swine can be caused by atypical mycobacteria

A

T

93
Q

Mycobacteria in swine can be caused by M. bovis and produces localized lesions

A

T

94
Q

M. tuberculosis is a common mycobacterium infection of pig

A

F

95
Q

Sawdust bedding can predispose pigs to infection by facultative pathogenic mycobacteria

A

T

96
Q

The habitat of pathogenic mycobacteria is the soil

A

F

97
Q

The habitat of facultative pathogenic mycobacteria is the soil

A

F

98
Q

Only cattle are susceptible to Mycobacterium bovis

A

F

99
Q

Some facultative pathogenic Mycobacteria can cause tuberculosis in cold blooded animals

A

T

100
Q

Mainly proliferative lesions can be seen in the late generalization phase of bovine tuberculosis

A

F

101
Q

Bovine tuberculosis is sustained by infected animals

A

T

102
Q

Fresh tuberculosis lesions in the lymph nodes are common in the early generalization

A

T

103
Q

Infected cattle shed the agents of bovine tuberculosis in milk

A

T

104
Q

Infected cattle shed the agents of bovine tuberculosis in tracheal discharge

A

T

105
Q

Infection of cattle with Mycobacterium tuberculosis is frequently asymptomatic

A

T

106
Q

The sensitivity of the intradermal tuberculin test is above 90% in cattle

A

T

107
Q

If the tuberculin test is negative, it has to be repeated immediately

A

F

108
Q

The tuberculin test in cattle can be false negative if the animal is infected with facultative pathogenic mycobacteria

A

F—false negative if old isolated infection, anergy too early infection and immunosuppressed

False positive=parallergy=other bacteria facultative pathogenic mycobacteria or heteroallergy if other genus bacteria with similar antigens like Corynebacterium pseudotuberculosis or actinomyces

109
Q

The tuberculin test in cattle can be false negative if the animal is infected with Mycobacterium tuberculosis

A

F

110
Q

The tuberculin test in cattle can be false negative if the animal is in the exhaust phase

A

T

111
Q

The tuberculin has to be injected in the skin fold in the skin intra dermal test

A

T

112
Q

The tuberculin test is used for the detection of infection of animals with mycobacteria

A

T

113
Q

The intradermal tuberculin test is negative if the increase of the thickness of the skin is 1.8 mm and there are no local lesions or signs

A

T

114
Q

The intradermal tuberculin test is positive if the increase of the thickness of the skin is 3.6 mm and there are local lesions or signs

A

T

115
Q

The intradermal tuberculin test is negative if the increase of the thickness of the skin is 3.6 mm and there is no local lesions or signs

A

T

116
Q

If the resistance of the animal is high, mainly exudative lesions of tuberculosis can be seen

A

F

117
Q

In the case of bovine tuberculosis aerogenic infection is the most frequent way of infection

A

T

118
Q

In the case of bovine tuberculosis always exudative lesions can be seen

A

F

119
Q

Selection (test & slaughter) and generation shift methods can be used for eradication of bovine tuberculosis

A

T–all 3 methods

120
Q

Europe is free from bovine tuberculosis; bovine tuberculosis does not occur in Europe at all

A

F

121
Q

Rifampicin is frequently used for the treatment of bovine tuberculosis

A

F–not used not allowed cannot prevent colonisation

122
Q

The thermal tuberculin test can be used in order to examine the organic reaction of bovine tuberculosis

A

T

123
Q

The tuberculin test in cattle can be false negative if only short time (1-3 weeks) has passed since the infection

A

T

124
Q

Positive reaction of the tuberculin test in cattle can be caused by infection with Mycobacterium tuberculosis

A

T

125
Q

False positive reactions of the tuberculin test in cattle can be caused by infection with certain Corynebacterium species

A

T

126
Q

Mycobacterium bovis is an agent of bovine tuberculosis

A

T

127
Q

If the cellular immune reaction of cattle is weak, mainly exudative lesions of tuberculosis can be seen

A

T

128
Q

Bovine tuberculosis cause mainly exudative lesions in calves below 1 month

A

F—pote eprolave afou en months to years to IP

129
Q

In case of infection with mycobacterium bovis the reaction against bovine and avian tuberculin is about the same in cattle

A

F–positive bovine needs to be around 4mm greater than the avian

130
Q

Cough is a typical clinical sign of bovine pulmonary tuberculosis

A

T

131
Q

Mycobacterium bovis and mycobacterium caprae belong to the mycobacterium tuberculosis complex

A

T

132
Q

The incubation time of bovine tuberculosis is 1-2 weeks

A

F

133
Q

Mycobacterium bovis can cause generalized tuberculosis in pigs

A

T

134
Q

The skin intradermal tuberculin test has to be read 24 hours after injection

A

F–72 hours

135
Q

Dermatitis nodosa is caused by mycobacterium bovis

A

F—tuberculosis nodosa which is small tubercules in lungs.

136
Q

Only aerosol infection occurs in the case of bovine tuberculosis

A

F

137
Q

The skin intradermal tuberculin test can be repeated within a week if necessary

A

F—42 days repeating if needed (6 weeks)

138
Q

Mycobacterium bovis can cause tuberculosis in humans

A

T

139
Q

The primary complex of bovine tuberculosis is generally seen in the gastrointestinal tract

A

F–95% in th resp. tract lungs

140
Q

False positive reactions of the tuberculin test in cattle can be caused by pre-allergy

A

F— paraallergy in false positive and prealergy in false negatives

141
Q

In the intradermal skin test for tuberculosis, other mycobacteria can cause false positive

A

T– yes and is called parallergy

142
Q

The skin intra-dermal tuberculin test is a type IV hyper-sensitivity test

A

T

143
Q

Mycobacterium bovis and Mycobacterium caprae can cause bovine tuberculosis.

A

T

144
Q

The tuberculin skin test is positive if the skin thickness is 2mm and local signs such as severe oedema of the neck is present

A

T– + = more than 4mm or local swelling CS

145
Q

In the exhaust phase of Tuberculosis, the tuberculin test can be false positive

A

F=false negative

146
Q

The primary complex in bovine tuberculosis is mainly in the respiratory tract

A

T

147
Q

The tuberculin test is inconclusive if the increase of the thickness of the skin fold is 3.2 mm and it is painful

A

T=local reaction is either (oedema, necrosis, Scab, enlarged LN +pain sensitivity)

148
Q

The tuberculin test is negative for 3 weeks after infection

A

T—false negative=prealergy=1-3week post infection

149
Q

Cattle are vaccinated every year in order to prevent tuberculosis

A

F

150
Q

The tuberculin reaction is positive if the increase of the thickness of the skin fold is 4.1 mm

A

T

151
Q

If the increase of thickness of the skin fold in the tuberculin test is 4.1 mm, the reaction is inconclusive

A

F

152
Q

If the positive tuberculin reaction is caused by facultative pathogenic mycobacteria the positivity will disappear after a few months

A

T

153
Q

Cough is a frequent sign of bovine tuberculosis

A

T

154
Q

Intestinal tuberculosis has no clinical signs in cattle

A

F

155
Q

Badgers can infect cattle with Mycobacterium bovis

A

T

156
Q

Vaccines are widely used to prevent bovine tuberculosis

A

F

157
Q

Mycobacterium bovis cannot cause tuberculosis in pigs

A

F

158
Q

Mycobacterium bovis can infect cage birds

A

T

159
Q

Parallergy lasts lifelong in the case of cattle

A

F—few months

160
Q

Inhalation is the most frequent form of infection in the case of bovine tuberculosis

A

T

161
Q

Parallergy results in false negative reaction in the tuberculin test

A

F

162
Q

If the thickness of the skin is increased with 3.4 mm in the tuberculin test and local lesions are present, test is inconclusive

A

F—positive
inconclusive is 2mm-4mm and no local reactions

163
Q

Tuberculotic cattle are treated with antibiotics for at least three weeks

A

F

164
Q

The skin intradermal tuberculin test has to be read after 72 h

A

T

165
Q

If the intradermal tuberculin test is inconclusive, it has to be repeated within a week

A

F-42 days

166
Q

If the skin fold become 3 mm thicker in the skin intradermal tuberculin test and is painful, the test is positive

A

T

167
Q

Mycobacterium avium subsp. avium can cause positive tuberculin reaction in cattle

A

T–false positive in this case parallergy

168
Q

At bovine tuberculosis the resistance of the infected animals effects the clinical manifestation

A

T

169
Q

At most cases bovine tuberculosis has a rapid, acute progression

A

F—most cases is chronic disease

170
Q

Bovine tuberculosis shows clinical signs mainly under the age of 6 months

A

F

171
Q

The main pathogen causing bovine tuberculosis is Mycobacterium tuberculosis

A

F

172
Q

Bovine tuberculosis only affects the lungs

A

F

173
Q

Bovine tuberculosis is a zoonosis

A

T

174
Q

Tuberculosis causes generalized disease by organic infection in cattle

A

T

175
Q

Tuberculosis cannot infect cattle per os

A

F

176
Q

Tuberculosis in cattle occurs especially in young animals

A

F

177
Q

Cattle tuberculosis can be diagnosed by serological methods

A

T
Allergy tests
Gamma interferon test
lymphocyte proliferation test
Elisa-antibodies

178
Q

Cattle tuberculosis is always generalized

A

F

179
Q

Tuberculosis in cattle is prevented with frequent vaccinations

A

F

180
Q

Cattle are infected with M. bovis mainly per os and enteric tuberculosis is most frequent

A

F

181
Q

Cattle infected with M. bovis will carry the bacterium for a maximum of 1 year

A

F-more

182
Q

In intestinal tuberculosis, diarrhoea is the main clinical sign

A

T

183
Q

In the case of bovine tuberculosis foetuses are generally not infected

A

T

184
Q

Generation shift can be used for eradication of tuberculosis

A

T

185
Q

Vaccination of 6-month-old calves with BCG vaccine will result eradication of tuberculosis

A

F

186
Q

After infection with Mycobacterium bovis cattle remain lifelong carriers

A

T

187
Q

The primary complex in cattle is generally in the lungs and the mediastinal lymph nodes

A

T

188
Q

In cattle extrapulmonary tuberculosis does not occur

A

F

189
Q

Late generalization is characterized by productive processes

A

F–exudative

190
Q

Chronic tuberculosis affects organs together with lymph nodes

A

T

191
Q

The skin intradermal tuberculin test is negative if the thickness of the skin increased by 4.5 mm

A

F

192
Q

Tuberculin test can detect about 50% of the infected animals

A

F–90-95% sensitivity

193
Q

The skin intradermal tuberculin test is highly sensitive in cattle

A

T

194
Q

The skin intradermal tuberculin test is negative if the thickness of the skin increased by 4.1 mm

A

F

195
Q

In case of positive tuberculin reactions in a herd, movement restriction has to be implemented

A

T

196
Q

The PPD-tuberculin (purified protein derivative) contains the antigenic abstract of the agent

A

T

197
Q

During the general tuberculin test we give the tuberculin SC or IV

A

F intradermal

198
Q

General tuberculin test is used to trigger a hypersensitivity reaction

A

T

199
Q

The tuberculin test can be false negative in cattle within 3 weeks after infection

A

T

200
Q

The intradermal tuberculin test can be: False positive in case of infection by Mycobacterium avium subsp. paratuberculosis

A

T

201
Q

The intradermal tuberculin test can be: False negative in case of anergy

A

T

202
Q

The intradermal tuberculin test can be: False negative in case of pre-allergy

A

T

203
Q

The intradermal tuberculin test can be: False negative in case of older, demarcated nodule

A

T

204
Q

Tuberculin test is false negative in case of old, encapsulated lesions

A

T

205
Q

Tuberculin test is false negative in case of pre-infection

A

T

206
Q

At the end of the disease the probe/intradermal skin test can be negative

A

T=old infection false negative in this case

207
Q

In other types of tuberculosis infections the intradermal tuberculin can be positive

A

T—fasle positive parallergy

208
Q

Using the thermal tuberculin test, organic reactions can be increased

A

T

209
Q

In case of para-allergic reaction we carry out the comparative tuberculin test. In case of para-allergic reaction we eliminate the positive animals immediately

A

T

210
Q

In case of para-allergic reaction we perform a test-cut.

A

F

211
Q

In addition to para-allergic test we can carry out a gamma interferon test

A

T

212
Q

In the case of avian tuberculosis, no tubercles are formed

A

F