Blood pt 2 Flashcards
term for stoppage of bleeding
hemostasis
3 ways of hemostasis
vascular spasms, platelet plug, coagulation
explain what happens in vascular spasms
the smooth muscle of a blood vessel wall constricts to stop bleeding
explain what happens in platelet plug formation
involves the clumping of platelets around the damage to stop the bleeding
explain what happens in coagulation
formation of prothrombinase, conversion of prothrombin into thrombin, and conversion of soluble fibrinogen into insoluble fibrin
major blood groups
A, B, AB, O
2 antibodies that help determine blood groups
antibody A and antibody B
what vitamin is needed for normal clot formation
vitamin K
disorder d/t Rh incompatibility between mother and fetus
hemolytic disease of the newborn
how do extrinsic pathways and intrinsic pathways differ
extrinsic pathways occur more rapidly and involve clotting factor X. intrinsic pathways occurs more slowly and involves clotting factor XIII, clotting factor X, and clotting factor V
explain the conditions that may cause hemolyic disease of the newborn
a) At birth, a small quantity of fetal blood usually leaks across the placenta into the maternal bloodstream. A problem can arise when the mother is Rh- and the baby is Rh+, having inherited an allele for the Rh antigens from the father
b) on exposure to Rh antigen, the mother’s immune system responds by making anti-Rh antibodies
c) During a subsequent pregnancy, the maternal antibodies cross the placenta into the fetal blood. If the second fetus is Rh+, the ensuing antigen-antibody reaction causes agglutination and hemolysis of fetal RBCs. Result is HON