Blood and Immune 9 Flashcards
pathogens
disease-causing agents
erythrocytes
(red blood cells) are biconcave discs with no nucleus
leukocytes
(white blood cells) colorless cells that circulate in body fluids
platelets
(thrombocytes) cell fragments without a nucleus
plasma
(fluid matrix of blood) contains proteins and other solutes
albumin
main protein in plasma
fibrinogen
blood clotter in plasma
globulins
antibodies in plasma
serum
plasma without fibrinogen
blood is made up of
45% formed elements and 55% plasma
blood
fluid that circulates through the heart, arteries, capillaries, and veins, transporting oxygen, carbon dioxide, and nutrients to the tissues
formed elements
blood cells and cellular fragments
packed cell volume
the volume of blood cells in a sample after it has been centrifuged; normally about 45% of the blood sample
plasma
liquid portion of blood that carries formed elements, clotting factors, electrocytes, and proteins
serum
liquid portion of blood left after removing the clotting factors and blood cells
bone marrow
soft tissue within medullary cavities of bone, with multiple functions including the production of blood cells
erythropoietin (EPO)
hormone released by kidneys that stimulates red blood cell production in bone marrow
hemopoiesis; hematopoisis
formation of various types of blood cells and other formed elements
lymphatic system
network of vessels, lymph nodes, and lymphatic organs that plays a role in immunity by collecting lymph
lymph
colorless liquid containing white blood cells that drains through the lymphatic system into the bloodstream
lymph node
bean-shaped body in which lymph is filtered and lymphocytes are formed
spleen
vascular lymphatic organ responsible for filtering blood, destroying old red blood cells, producing red blood cells before birth, and storing blood
erythrocyte; red blood cell
red blood cell that carries oxygen and carbon dioxide
hemoglobin (HGB, Hb, Hgb)
protein in red blood cells that binds to oxygen; gives red blood cells the characteristic color
iron (Fe)
essential trace element necessary for hemoglobin to transport oxygen in red blood cells
macrocyte
a large red blood cell
Rh factor
protein substance present in the red blood cells of most people (85%); it is capable of inducing antigenic reactions
leukocytes; white blood cells (WBC)
largest blood cell; protects against pathogens, foreign substances, and cellular debris
granulocyte
white blood cell with visible granules; the three types pf granulocytes are named according to the type of dye to which each is attracted
neutrophil
type of granulocyte that fights against bacterial infections; stains a neutral pink; 60-70% of circulating WBCs
eosinophil
type of granulocyte that functions in allergic reactions and against parasites; stains red; 2-4% of circulating WBCs
basophil
type of granulocyte that releases histamine in allergic reactions and inflammatory responses; stains a dark blue with a basic dye; 0.5-1.0% of circulating WBCs
agranulocyte
white blood cell without clearly visible granules
lymphocyte
type of agranulocyte that circulates in the lymphatic system and is active in immunity; 20-25% of circulating WBCs
B lymphocyte; B cell
white blood cell that, when in contact with a foreign antigen, produces antibodies to inactivate the antigen
T lymphocyte; T cell
white blood cell that matures in the thymus and specializes in creating immune response
monocyte
largest type of white blood cell; 3-8% of circulating WBCs
macrophage
enlarged and matured monocyte active in phagocytes (eating and destroying)
platelets (PLT); thrombocytes
cellular fragments in the blood that stick together, forming a clot
clotting factors
any of the various plasma components involved in the clotting process
coagulation
clotting; changing from a liquid to a solid state
fibrin
elastic fiber protein needed in clotting and derived from fibrinogen
fibrinogen
plasma protein that is converted into solid threads called fibrin
antibody (Ab)
soldier-like protein that protects the body and inactivates antigens; provides immunity against specific substances and microorganisms
antigen (Ag)
agent of substance that provokes an immune response
histamine
substance released by damaged cells that increases blood flow to the area, causing an inflammatory response (inflammation) involving heat, redness, swelling, and pain
immune response
the body’s reaction to an antigen
immunity
protection against disease
pathogen
any virus, microorganism, or other substance that causes disease
phagocytosis
cellular process of eating and destroying substances, usually by the neutrophils and macrophages
chrom/o, chromat/o
color
cyt/o
cell
erythr/o
red
granul/o
granules
hem/o, hemat/o
blood
immun/o
immune, safe
leuk/o
white
lymph/o
lymph
neutr/o
neutral
nucle/o
nucleus
path/o
disease
phag/o
eat, swallow
phleb/o
vein
plas/o
formation, growth
thromb/o
blood clot
auto-
self, same
basi-, baso-
base
macro-
large, long
micro-
small
mono-
one
pro-
before, promoting
poly-
many, much
-cyte
cell
-emia
blood (condition of)
-sis
condition, process
-gen
origin, production
-lysis
destruction, breakdown, separation
-osis
abnormal condition
-penia
deficiency
-philia
attraction of, liking
-poiesis
production, formation
-rrhage
flowing forth
-y
condition of
autoimmunity
pertaining to one’s immune system attacking its own tissues or cells
cytopathic
pertaining to a disease or disorder of a cell or cellular component
hemopoietic; hematopoietic
pertaining to the formation of blood cells
hemolytic
pertaining to the rupture or destruction of red blood cells
hemorrhagic
pertaining to profuse or excessive bleeding
hemostasis
stopping blood flow or arresting bleeding
hypersensitive
condition of excessive response or an exaggerated sensitivity to a stimulus
Inflammatory
pertaining to heat, redness, swelling, and pain in response to tissue injury
predisposition
condition of being susceptible to disease
proliferative
growing and increasing in number of similar cells
rejection
immunologic response of incompatibility to a transplanted organ or tissue
systemic
pertaining to the whole body
virulent
denotes an extremely toxic pathogen
anemia
condition in which the number of red blood cells, hemoglobin, or packed cell volume is lower than normal
aplastic anemia
disorder in which the bone marrow does not produce enough red blood cells
iron deficiency anemia
disorder in which hemoglobin is unable to transport oxygen due to a lack of iron
pernicious anemia
disorder in which the number of red bloods cells decreases with simultaneous enlargement of individual cells (macrocytes) due to an inability to absorb vitamin B12
hemorrhagic anemia
blood loss anemia; disorder involving lack of red blood cells due to profuse blood loss
thalassemia
disorder caused by a genetic defect resulting in low hemoglobin production
sickle cell anemia
disorder caused by a genetic defect resulting in abnormal hemoglobin causing a sickle-shaped red blood cells, which have difficulty moving through small capillary vessels
autoimmune disease
condition in which the immune system attacks normal body tissues
hemophilia
bleeding disorder due to a deficiency of a clotting factor
clotting disorder
condition characterized by an inability of blood to coagulate
thrombocytopenia
disorder involving low levels of platelets in the blood
idiopathic thrombocytopenic purpura (ITP)
disorder resulting from platelet destruction by macrophages characterized by bruising and bleeding from mucous membranes
von Willebrand disease (vWD)
bleeding disorder characterized by a tendency to bleed primarily from the mucous membranes due to a deficiency of clotting factor
hemochromatosis
excessive absorption and storage of dietary iron in body tissues causing dysfunction
mononucleosis
increase of mononuclear leukocytes with symptoms of fever, enlarged cervical lymph nodes, and fatigue
pancytopenia
deficiency in all types of blood cells
polycythemia
increase in number of red blood cells
rheumatoid arthritis (RA)
autoimmune disease causing progressive changes and inflammation in multiple joints, especially in the hands and feet
septicemia
spread of microorganisms or toxins through circulating blood
Sjögren sydrome
chronic autoimmune disease characterized by degeneration of the salivary and lacrimal glands causing dryness of the mouth and eyes and other mucous membranes
systemic lupus erythematosus (SLE)
inflammatory, autoimmune, connective tissue disease that can affect all organ systems
thrombosis
abnormal presence of clotting within a blood vessel
albumin
measurement of this protein level; used to diagnose liver or kidney problems, inflammation, malnutrition, or dehydration
bilirubin
screen for liver disorders or anemia; bile, found in bilirubin, is a yellow pigment formed from hemoglobin, and excess is associated with jaundice (abnormal yellowing of the skin)
blood smear
evaluation of the appearance and number of blood cells and the different types of white blood cells
complete blood count (CBC); hemogram
automated count of all blood cells
erythrocyte sedimentation (ESR)
Time management of red blood cells settling in a test tube over one hour; used to diagnose inflammation and anemias
hematocrit (HCT, Hct)
percentage of red blood cells in a sample of whole blood; used to diagnose various disorders including anemia
hemoglobin (HGB, Hgb, Hb) test
test for the red blood cell protein responsible for binding oxygen; used to diagnose various disorders including anemia
platelet count (PLT)
number of platelets present; used to diagnose bleeding disorders or bone marrow disease
red blood count (RBC)
number of erythrocytes present; used to diagnose various disorders including anemia
white blood count (WBC)
number of leukocytes present; used to diagnose various disorders, including infections and diseases, and for monitoring treatment
crossmatching
blood typing test for compatibility between donor and recipient blood
culture and sensitivity (C&S)
growing a microorganism from a specimen taken from the body to determine its susceptibility to particular medications
prothrombin time (PT)
measurement of time for blood to clot
differential white blood count; differential count
test that determines the number of each type of white blood cell in a blood sample
antinuclear antibody (ANA) test
assessment for autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, and others
Epstein-Barr virus (EBV) antibody test
diagnostic test for mononucleosis and evaluation of Epstein-Barr virus
mononucleosis spot test
assessment for mononucleosis
rheumatoid factor test
test for rheumatoid arthritis and Sjögren syndrome
apheresis
infusion of a patient’s own blood after certain cellular or fluid elements have been removed; used especially to remove antibodies in treating autoimmune disorders
blood transfusion (BT)
transfer of blood between compatible donor and recipient
autologous blood
blood donated for future use by same patient; usually presurgical
blood component therapy
transfusion of specific blood components such as packed red blood cells, plasma, or platelets
homologous blood
blood donated from same species for use by a compatible recipient
bone marrow aspiration (BMA)
removal of a small amount of fluid and cells inside the bone with a needle and syringe
bone marrow transplant (BMT)
transfer of bone marrow from one person to another
immunization; vaccination
administration of a weakened or killed pathogen, or a protein of a pathogen, to cause the immune system to create antibodies for future protection
immunosuppression
use of chemotherapy or immunosuppressant drugs to interfere with immune responses; usually prescribed for autoimmune disorders
phlebotomy; venipuncture; venotomy
incision into a vein to inject a solution or withdraw blood
plasmapheresis
removal and replacement of a patient’s own blood after plasma has been removed and replaced with a plasma substitute
splenectomy
surgical removal of the spleen
antibiotic
drug that kills or inhibits the growth of microorganisms
anticoagulant
drug that prevents or inhibits blood clotting
antihistamine
drug used to stop the effects of histamine; used especially to treat allergies
hemostatic agent; procoagulant
drug that stops the flow of blood within vessels
immune serum; antiserum
serum containing antibodies against specific antigens; used to treat specific diseases
immunosuppressant
drug used to suppress or reduce immune responses in organ transplant recipients or those with severe autoimmune diseases
thrombolytic agent
drug that dissolves a blood clot
vaccine
preparation composed of a weakened or killed pathogen
allergology
medical specialty concerned with diagnosis and treatment of allergic conditions
hematology
medical specialty concerned with diagnosis and treatment of disorders of the blood and blood-forming organs
immunology
medical specialty concerned with immunity, allergy, and induced sensitivity
rheumatology
medical specialty concerned with diagnosis and treatment of rheumatic conditions (those affect joints), arthritis, and autoimmune diseases
Ab
antibody
Ag
antigen
ANA
antinuclear antibody test
BMA
bone marrow aspiration
BMT
bone marrow transplant
BT
blood transfusion
CBC
complete blood count
C&S
culture and sensitivity
EBV
Epstein-Barr virus
EPO
erythropoietin
ESR
erythrocyte sedimentation rate
Fe
iron
HCT, Hct, ht
hematocrit
HGB, Hb, Hgb
hemoglobin
ITP
idiopathic thrombocytopenic purpura
PLT
platelet or platelet count
RA
rheumatoid arthritis
PT
prothrombin time
RBC
red blood cell; red blood count
SLE
systemic lupus erythematosus
vWD
von Willebrand disease
WBC
white blood cell; white blood count