Block 4 Flashcards
What is the primary agent of large animal pyelonephritis??
Corynebacterium renale
Which kidney is more likely to get pyelonephritis?
Left
Is pyelonephritis a primary tubulointerstitial disease?
YES
What is found in urinalysis of large animal pyelonephritis?
Isosthenuria
Blood, protein, and leukocytes
What is the definitive diagnostic for pyelonephritis?
Urinalysis
What is most common stone in dogs?
Struvite
What is most common stone in cats?
Calcium oxylate
What stone is associated with UTI in dogs?
Struvite
What stone is associated with high Mg and high K in cats?
Struvite
What is the most common stone in cat’s bladder?
Struvite
What stone is predisposed to intact dogs?
Cystine
What are the 2 categories of mictoration disorders?
Disorders of voiding
Disorders of storage
What are the top 4 disorders of urine storage?
Urethral sphincter mechanism incompetence
Ectopic bladders
Overactive bladder
Idiopathic incontinence
What is the primary breed of urinary incontinence?
Boxer
What should you advise the client about spaying their dog in terms of urinary incontinence?
Should wait longer in larger dogs and wait until after first heat but before the 2nd heat!
What hormone leads to low urethral muscle tone?
Estrogen
What is a common breed for ectopic ureters?
Golden retriever
What are the 4 disorders of voiding?
Reflex Dyssyngeria
Bladder atony
Automatic bladder (UMN)
Autonomous bladder (LMN)
What is functional outflow obstruction? (FOO)
Poor relaxation of the detrusor muscle disallowing urine outflow (likely a neurological cause)
What is the true diagnosis of FOO?
Large amounts of residue urine (more common in male dogs)
When the dog stops urinating is the bladder still large?
What increases earlier that creatinine?
SDMA
How is uremia different from azotemia?
Azotemia is an increase in BUN or creatinine but uremia is just a general decrease in kidney function
What is first sign of CKD in cats?
Decrease in USG
What is first sign of CKD in dogs?
Proteinurea
What is the normal USG for cats?
> 1.040
What is something a lot of old cats with UTIs have?
CKD
What level phosphorus is CKD cats supposed to have compared with acute kidney cats?
CKD = low K
Acute = high K
What do you need to do before IRIS staging a patient?
Fast them
What is stage 1 of IRIS staging a cat? dog?
Creatinine
Cat - <1.6
Dog - < 1.4
What is stage 2 of IRIS staging a cat? Dog?
Cat - 1.6 - 2.8
Dog - 1.4 - 2.8
What is stage III of IRIS staging?
2.9-5.0
What is stage 4 of IRIS staging/
> 5.0
What is normotensive?
<150 systolic
<95 diastolic
What is borderline hypertensive?
150-159 systolic
95-99 diastolic
What is hypertensive?
160-179
100-119
What is severe hypertensive?
> 180
<120
What is non proteinuric in a cat? Dog?
Cat - <0.2
Dog - <0.2
What is borderline proteinuric in a cat? Dog?
Cat - 0.2-0.4
Dog - 0.2-0.5
What is proteinuric in cat? Dog?
Cat - >0.4
Dog - >0.5
What type of disease is CKD in a cat?
Tubulointerstial disease
What type of disease is CKD in a dog?
Proteinuric glomerular disease
What are 2 blood pressure things that cats get with CKD?
Hypertension
Retinal damage
Do dogs get hyper or hypo kalemia with CKD?
Hyperkalemia (opposite of cats)
CATS DONT WANT TO EAT WITH CKD
What is the primary reason for euthanasia of CKD cats?
Unwillingness to eat
When normal phosphorus management is disrupted, what is secreted?
PTH
How do you manage hyperphosphatemia in CKD cats?
Low phosphorus diet
Do CKD cats poop more or less?
Less
Hyperphosphatemia and hypokalemia in cats with CKD!!!
If you see a cat with retinal lesions, what should you think?
CKD!
What type of anemia is seen in cats with CKD?
Non-regenerative
What happens to the size and weight of FIC cats’ adrenal glands ?
Decreased
What is the GAG layer of the bladder?
Layer closed to lumen
What is pathophysiology of FIC?
C fibers activate SP which activate mast cells
Does FIC increase risk of crystalluria?
NO
What is most common clinical sign of FIC?
Peeing outside of the box (periuria)
What is a predisposing factor for FIC?
Overweight
Do male cats with obstruction history get FIC?
Yes, more often!!
What are 3 most common urinary issues with cats?
UTI
Urolithiasis
FIC
What is most common underlying cause in dogs of urinary issues?
Urinary calculus
What is most common underlying issue in cats of urinary issues?
FIC
What causes FIC the most in cats?
Urethral plugs
What does hyperkalemia during a blockage cause?
Bradycardia
What is a unique aspect of a feline PE for blockage?
Hypothermia
Will cats have a decreased or increased heart beats with urethral obstruction?
Decreased
What 2 things are very indicative of urinary obstruction (hyp erkalemia)?
Hypothermia
Bradycardia
What is the most common organ that causes uroabdomen?
Bladder
What develops in the peritoneum due to a bladder rupture?
Peritonitis
UO and uroabdomen are roughly the same
What should be seen in abdomenocentisis in uroabdomen?
Creatinine 2x that of blood
At what percent loss do we start to see an increase in phosphorus?
80%
What will the urine specific gravity be if the disease is pre-renal?
High
What will the urine specific gravity be if the disease is renal?
Low
What does high BUN compared to creatinine mean?
Dehydration or fluid loss
What does high creatinine compared to BUN mean?
Liver disease, muscle injury, well-muscled animal, low protein diet
What is isosthenuria?
1.007-1.015
What is a primary cause of polyurea?
Primary diabetes insipidus
What is secondary polyurea?
Can release ADH but can’t react to it
What are some common causes of secondary polyurea?
Diabetes mellitus
Cushing
Addisons
Chronic/acute renal disease
Liver disease
What is the top reason for PU/PD in dogs? Cat?s
Both renal disease
What is the #2 cause of PU/PD in dogs? Cat?
Dog - diabete mellitus
Cat - hyperthyroidism
What test is run last and differentiates between diabetes insipidus and psychogenic polydipsia?
Water Deprivation test (ddavp)
What do you put IV for an excretory urogram?
Iodinated solution NEVER BARIUM IV!!
What can you see on an excretory urogram that is unique?
Ureters
Is azotemia a contraindication for excretory urogram?
NO!
Dehydration is so rehydrate first!
What is seen on excretory urogram at about 5 minutes at the entry to the bladder?
J hook
What is in a positive contrast?
Iodinated
What is in a negative contrast?
CO2 or NO
What are indications for EU
See ureters
Better evaluate kidneys
What are indications for a contrast cystography?
Masses
Bladder tears
Calculus
Location of bladder
What are indications of contrast urethrogram?
Abnormal urination
Hematuira
Pelvic fractures
How is excretory urogram performed?
IV bolus of iodine
What are the red streaks in a kidney indicative of?
Acute pyelonephritis
What does chronic pyelonephritis look like?
Fibrotic lesions within the cortex and medulla
What is the most common bacteria of pyelonephritis
E. coli
What species most commonly gets ectopic ureters? What are they?
Dogs
Ureters that attach more caudal than the trigone
What species most commonly has a patent urachus?
Foals
What species causes canthardin toxicity?
Blister beetle
What is the most common tumor of the bladder tumors in dogs and cats?
Urethral cell carcinoma
What breed most commonly gets urothelial cell carcinomas?
Scottish terriers
Why type of infection (viral, fungal, bacterial) is most common for UTIs?
Bacterial
What does pollakuria mean?
Inflamed bladder
Does WBC in urine indicate a UTI?
NO! Just inflammation
Can you treat a dog with suspected UTI with antibiotics? Cats?
Dogs - Yes
Cats - NO!
Where should you get the urine for a culture?
Cysto
What is a complicated UTI?
Recurrent
What is a relapsing UTI infection?
Infection that is same bacterial infection, previous infection was not cleared
What is a reinfection UTI?
Infection that has a different bacteria
What will a patient normally have if they have a fungal UTI?
Diabetes
What changes in the mare 24-48hr prior to foaling?
Ca and K increase
Na decrease
PH decreases <7
What should the specific gravity of colostrum be above?
1.06
What level should serum antibodies be for a foal at 12 hr ?
> 800
What is the most common tumor in intact female dogs?
Mammary gland neoplasia
What are the 3 risk factors for mammary gland neoplasia?
Hormones (spay)
Diet (red meat)
Obesity (adipose tissue is source of estrogen)
What are benign neoplasms of the dog mammary gland called?
Mammary adenomas
Mixed mammary tumors
What are the malignant canine neoplasms of the dog?
Adenocarcinomas
What breed type most commonly gets mammary gland neoplasias?
Small dogs
What is the breakdown of malignant/benign in canine neoplasia?
50% benign 50% malignant
What percentage of feline mammary gland neoplasias are malignant?
Over 80%
What percent of female intact rats will get mammary neoplasia?
30-90%
Only 20% malignant
What are the 2 smooth muscle neoplasms of the uterus?
Leiomyomas (benign)
Leiomyosarcomas (malignant)
What is the most common neoplasms coming from the female reproductive tract?
Leiomyeloma
What is the most common uterine neoplasm in the cow?
Lymphosarcoma
What neoplasm is associated with bovine leukemia virus?
Lymphosarcoma
What is the most common malignancy in teh rabbit?
Adenocarcinoma (60-80% of intact rabbits, wow)
Where does the uterine adenocarcinoma arise from?
Endometrium
What is endometriosis?
Endometrial tissue outside of the uterus
How Is vaginal polyp appear different from vaginal leiomyoma?
Poly is on top of the skin while leiomyomas are underneath of the dermal layer
What percent of intact female dogs will get pyometra by 10
25%
What is the poster child breed for pyometras?
Bernese mountain dog (older larger dogs)
What increases the risk of pyometras?
Higher risk if never pregnant
What is cystic endometrial hyperplasia?
Cystic thickening of the endometrium
Intact females develop over time
Comes from prolonged/repeat exposure to estrogens and progesterone
Not all dogs with cystic endometrial hyperplasia (CEH) will get pyometras
What is the process of pyometras?
Cervix opens > Bacterial colonization > Bacteria trapped (maybe in CEH cysts) > cervix closes > bacteria proliferates
What is an “open” pyo?
Cervix is open
Why do dogs with a pyo sometimes have Pu/PD?
Endotoxemia on kidney