Bleeding Disorders Flashcards
Sites of bleeding
Orifices e.g. epistaxis or
uterine bleeding
Cutaneous eg petechiae or
ecchymosis or hematoma
Internal bleeding e.g.
intracranial hemorrhage or
muscle hematoma
Hereditary connective tissue
disorders
(abnormal collagen
Ehlers Danlos
affecting the mucous membranes
and skin leading to epistaxis, GI
bleeding and chronic iron
deficiency
Hereditary hemorrhagic
telangiectasia
Vascular disorders
Hereditary Acquired
Hereditary hemorrhagic
telangiectasia
Hereditary connective tissue
disorders
(abnormal collagen)
E.g. Ehlers Danlos
Acquired
Simple bruising
Senile purpura
Vasculitis (palpable) eg Henoch-Schonlein purpura
Purpura secondary to infections or vitamin C deficiency
Immune thrombocytopenic purpura (ITP)
Diagnosis
Ttt
is an acquired isolated thrombocytopenia < 100 x 10/L in absence of
any underlying cause
Diagnosed by exclusion of other causes
TTT for symptomatizing patients by Steroids, immune suppressive
drugs or splenectomy
QUANTITATIVE
THROMBOCYTOPENIA
Itp
Dec produc
Inc consumption
Inc destruction
Dilutionsl
Qualitative thompocytopenia
Hereditary:
Glanzmann’s thrombasthenia
Bernard-Soulier syndrome
Acquired:
Drugs as aspirin, NSAIDS
Renal failure
Defect in carier of factor 8
Von willebrand dx
Chrismats dx
Hemophilia B (Christmas disease): factor IX deficiency and X
linked recessive disorder
Hemophilia A
factor VIII deficiency and X-linked disorder
Coagulation disorders
Congenital Acquired
Congenital
• Hemophilia A: factor VIII deficiency and X-linked disorder
• Hemophilia B (Christmas disease): factor IX deficiency and X
linked recessive disorder
• Von Willebrand disease : deficiency of VWF a carrier of factor
Acquired
Defective synthesis
Liver disease: deficiency of vitamin K dependent coagulation
factors
Increased consumption
Disseminated intravascular coagulation (DIC)
