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Back up cards AAB > BBRh > Flashcards

BBRh Flashcards

1
Q

3 bacteria implicated in contamination of blood, 1 thats not3 parasites transmitted by blood

A

Yersinia, Citrobacter, Pseudomonas-these are the books answer-possibly staph/strepE.Coli has notPlasmodium, Trypanosoma(cruzi), Babesia

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2
Q

Primary resonse Ig, time appears…Secondary response Ig, time appears…% get immunizied to blood grp ag

A

Primary IgM, 7-14 daysSecondary IgG 1-2 days1-4%

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3
Q

ABO labels versus dyes colors-A,B,O,AB-A,B,D/A1B

A

Labels:-A: yellow-B: pink-O: blue-AB: black/gray/whiteDye:-A: blue-B: yellow-D/A1B: clear

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4
Q

anti -A1 made from…anti-H made from…

A

anti -A1 made from…Dolichos biflorusanti-H made from…Ulex europeus

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5
Q

Potentiators:-shortens incubation, increases speed/sensitivity, decreases zeta, phosphate buffered saline/glycine-increases sensitivity for IAT, longer incubation-increases sensitivity, removes water increasing concentration of ab, enhances warm auto-eliminate rxns, can enhance coldwarm auto-reduce disulfide bonds, eliminates Kell

A

Potentiators:LISS low ionic strenght sln-shortens incubation, increases speed/sensitivity, decreases zeta, phosphate buffered saline/glycineBSA/albumin-increases sensitivity for IAT, longer incubationPEG-increases sensitivity, removes water increasing concentration of ab, enhances warm autoProteolitic enyzmes-eliminate rxns, can enhance coldwarm autoDTT, dithiothreitol-reduce disulfide bonds, eliminates Kell

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6
Q

Reaction grading…which one is caused by transfusion, some agg with sea of free rbc…which one is microscopic/cloud…4+3+2+1+MFWPNeg

A

Reaction grading…4+ solid button,clear3+ lrg clump, clear2+ med clumps, clear1+ sml agg, turbidMF some agg, sea of free(transfusion)WP microscopic cloudyNeg no agg,cloudy

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7
Q

Allogenic Donor reqs:Age:Temp/C/F:Wt:Hmg/Hct: femalemaleBP:Pulse:

A

Allogenic Donor reqs:Age: >=16Temp/C/F: 37.5C/99.5FWt: >=110lb/50kgHmg/Hct: 12.5/38%female 12.5/38%male 13/39BP: 90-180/50-100Pulse: 50-100

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8
Q

Autologous donor req…Age..Hmg/HCT..other…

A

Autologous-no age req-Hmg/HCT 11/33%-no bacterimia-collect >72hrs before-ABO/Rh testing

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9
Q

Vaccine defferments..TB skin pos…measles/mumps/rubeola/polio no symptoms..Hep B…Germen measles/chicken pox/ West Nile….

A

Vaccine defferments..TB skin pos…no defferal if all else normalmeasles/mumps/rubeola/polio no symptoms..2 wksHep B…3 wksGermen measles/chicken pox/ West Nile….4 wks

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10
Q

Wait time for plasmapheresis donor to wait before donate WB…Wait time for WB donor to donate plasmapheresis…

A

Wait time for plasmapheresis donor to wait before donate WB…48hrsWait time for WB donor to donate plasmapheresis…72hrs-need to test TP if >1x/2mths at 4mth intervals

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11
Q

Main reason to be defered for 1yrs…3 random…

A

exposure to hepatitis, malaria, HIV-had sex/living with, tatoo/trans, hep B immuneglobulin, mucous/skin->72hrs in jail-completed syphillis/gonn treatment or reactive STS-bitten by dog

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12
Q

Reason to be deffered 3yrs

A

asymptomatic from endemic area of malaria or had malaria before/completed treatment

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13
Q

Permnament deferral main reasons…random reason…

A

Permnament..-definete disease, habits high risk for hep/malaria/CJD,Babeosis,T.cruzi, HIV, HTLV-Viral hep after age 11-drug-human growth hormone

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14
Q

Main testing for products…

A

ABO/Rh, ab screen-Syphillis/RPR-Hepatitis(HBsAg,antiHBc, antiHCV)-HIV(anti1/2)-HTLV(anti1/2)-T.cruzi, WN, Zika, Babesia

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15
Q

RBC temps etcstorage…transport..open good for…Frozen RBC temp, time-% glycerol, thaw at, store at, good for1 unit raises hmg/hct by

A

RBC nonfrozen-store 1-6C-transport 1-10-open=24hrsFrozen: -65C, 10yrs-40% glycerol, thaw at 37C, store 1-6, good for 24hrsraise 1g/3%(rbcx3=hct)

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16
Q

FFP storage:-shorest time, longest time-thaw temp, store at, time-good for..Cryo storage-2 main things contain-good for once thawed, kept at-thawed/open time

A

FFP coag def-1 yr at -18-7yrs at -65-thaw at 30-37, store 1-6, 24hrsCryo fibrinogen, F8-1 yr at -18-6hrs thawed, leave at RT-4hrs thawed/pooled

17
Q

PLTS:-days, temp, with-open: pooled, apheresisGranulocytes/washed-time good for with no-washed preventsIrradiated -days -prevents

A

PLTS-light spin removes rbc, heavy spins down wbc/plts-5 days, 20-24 w/agitation-4 hrs plts pooled open-24hrs aphresis openGranulocytes: 24hrs, 20-24,no agitationwashed rbc: 24hrs, prevents allergy to plasma proteins in IgA defIrradiated: 28 days, prevents GVHD

18
Q

additivesshorest to longest…

A

rejuvenating sln: restores 2,3DPG/ATP-store 1-6C, use w/in 24hrsACD/CPD/CPD2: 21 days-anticoag citrate dextrose, -citrate phosphate dextroseCPDA1: 35 days, has adenine at endADSOL/AS/additives: 42 days

19
Q

Storage of blood changes

A

Decreased:-pH (lactic acid)-Na (moves into cells while K moves out)-2-3DPGIncreased: -K(moves out while Na moves in)-NH4

20
Q

Backbone of sugars is…O gene is…H is…-H gene codes for/what is glycosyltransferase/sugar A gene codes for..B gene codes for..

A

Backbone is Gal with Fuc off bottomGenes add onto Gal to the left…O gene is inactive, H is unmodifiedhas fuco-syl-transferase/fucoseA has N-acetyl-galac(NAC)B has D-galac

21
Q

Bombay phenotype is..antibodies in serum..Phenotype with absense of Rh…

A

absense of ABO ag, Ohhas A,B,H-type as O-not agg w/anti-H, no HRhnull is absense of Rh ag

22
Q

H ag greatest to leastgreatest, least

A

greatest H is O, least is Oh(none)A2>B>A2B>A1>A1BO>A2>B>A2B»A1>A1B>Oh-A2>B-more A, B less H so A2>A2B-A2>A1

23
Q

Se: expression ABO ag in BF, secretor status-dominant, 80% have Se geneSe codes for these three…-need….to have A or B-Se doesn’t code forLe: adsorbed onto red cell, in saliva/plasma-need Le to make…-need.. to make…

A

Se codes for H, then A and B, doesn’t code for SeLe:-need Le to make Lea-need Lea to make Leb

24
Q

ABO frequency greatest to least/%

A

O>A>B>ABO 46A 41B 9AB 4

25
Q

Subgroups:-MF with antiA, neg with antiA1 lectin…-A1 cell pos, antiA1 lectin neg-antiA 3+, antiB 3+, A1 cells 2+, antiA1Lectin neg

A

Subgroups:A3 is mixed field w/antiA1Ax isnt mixedMF with antiA, neg with antiA1 lectin: A3-barely any A=MF,-antiA1 lectin neg=no A1 ag=not A1A1 cell pos, antiA1 lectin neg=Ax-A1 cell pos=has antiA1-antiA1 lectin neg=not A1antiA 3+, antiB 3+, A1 cells 2+, antiA1Lectin neg: A2B-antiA,anti B 3+=AB-A1 cells 2+=has antiA1=not A1-antiA1 lectin neg=not A1=A2

26
Q

Autoab that is IgG, donath landsteiner, PCHab that is IgM, cold agg disease, Mycoplasma pneumonia, blacks…ab seem infants, infectious mono…

A

P: Autoab that is IgG, donath landsteiner, PCHI: ab that is IgM, cold agg disease, Mycoplasma pneumonia, blacks…i: ab seem infants, infectious mono…

27
Q

5 naturally occuring ab

A

ABOLewis, P, MCw

28
Q

Rh null…Oh…

A

Rh null no Rh agOh no ABO ag

29
Q

Tja part of..Cw/f part of…U part of…

A

Tja/PP1PK part of PCw/f part of RhU part of MNS

Back up cards AAB (26 decks)

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