Bacteria Chapter 22-18-19 Helicobacter- Pseudomonas - Bordetella - Corynebacterium Flashcards
describe helicobacter pylori
- gram negative vibrio
what chemical reaction does helicobacter pylori cause
urea + H2O -> CO2 + ammonia
what are the virulence factors for helicobacter pylori and what do they do
-urease: urea-> ammonia -> pH increase, neutralization of stomach acid
- VacA: protein that acts on gastric mucosal epithelia and promotes flow of urea into stomach
- CagA: protein injected into host epithelia -> cells change
- mucinase
- flagella
how do organisms survive the acidity of stomach juices
by producing a powerful urease
- upon reaching the layer of mucus they penetrate to the epithelial surface where bacterial products incite an inflammatory response
- thinning of mucus layer occurs and 10 to 20% of infected individuals develop ulcerations
- only small percentage develop cancer but more than 90% of individuals with stomach cancers are infected with H pylori
how are gastric ulcers treated
- no preventative
- 2 antibiotics plus a medication to suppress stomach acid
what is the initial infection immune response of gastric ulcers
IgM followed by IgA and IgG which suppresses bacterial growth and leads to the typical low level persistent infection which remains symptom free for 80-90% of carriers
what are the symptoms of helicobacter pylori
no symptoms in most people
describe pseudomonas aeruginosa
gram negative rods
- polar flagella
- obligate aerobe
- simple nutrient requirements
- broad temperature range 20-43 Celcius
how are pseudomonas aeruginosa cells arranged
pairs
what are the virulence factors for pseudomonas aeruginosa
- alginate: adherence, protection from dehydration and immune evasion
- lipopolysaccharide: lipid A is endotoxic; core interacts CFTR; O antigen protects from complement- mediated killing
what is alginate’s possible contribution to virulence
biofilm formation
describe opportunistic pathogens
-common in environment
- resistance to many chemical disinfectants
- R-plasmid based resistance to many antibiotics
what types of pathogens are major problems in hospitals
opportunistic pathogens in nosocomial infections
where are opportunistic pathogens seen in hospitals
- lungs: artifical ventilators, cystic fibrosis
- skin: burn victims, folliculitis
- bladder infections
- ear infections
- eye infections
what characterizes pseudomonas aeruginosa
soluble blue green dye pyocyanin and pyoverdin