B8-026 Pathology of the Ovaries

Question 1

mutations commonly associated with progression of ovarian epithelial tumors [3]

Answer 1

KRAF
BRAF
ERBB2

(high grade serous cysts have BRCA1/2 and Tp53 mutations)

Question 2

benign
most common ovarian neoplasm
lined by fallopian tube-like epithelium (cilia)

Answer 2

serous cystadenoma

Question 3

most common malignant tumor of ovary

Answer 3

serous carcinoma

Question 4

invasion and papillary growth
psammoma bodies
p53 mutation

Answer 4

serous carcinoma

Question 5

benign
multiloculated, large cyst
lined by mucus-secreting columnar epithelium

Answer 5

mucinous cystadenoma

Question 6

malignant cyst
rare
may be metastatic from appendiceal or other GI tumors

Answer 6

mucinous carcinoma

Question 7

presents with expansive or infiltrative pattern

(expansive is lower right image)

Answer 7

mucinous carcinoma

Question 8

composed of endometrial-type cells, similar morphology to endometrioid carcinoma of endometrium

Answer 8

endometrioid adenocarcinoma

Question 9

epithelial tumor associated with endometriosis, hypercalcemia and vascular thrombotic events

Answer 9

clear cell carcinoma

Question 10

involvement of the ovaries but appendiceal mucinous neoplasm can result in

Answer 10

psuedomyxoma peritonei “jelly belly”

Question 11

benign
most common ovarian tumor in young females
AKA dermoid cyst

Answer 11

mature teratoma

Question 12

cystic mass with elements from all 3 germ layers

Answer 12

mature teratoma

Question 13

thyroid tissue in dermoid cyst can cause

Answer 13

hyperthyroidism (struma ovarii)

Question 14

mature teratoma with malignant transformation can result in [2]

Answer 14

squamous cell carcinoma
adenocarcinoma

Question 15

malignant, aggressive germ cell tumor
contains fetal tissue and neuroepithelium

Answer 15

immature teratoma

Question 16

typically represented by immature/embryonic-like neural tissue

Answer 16

immature teratoma

Question 17

tumor marker:
increased LDH

Answer 17

dysgerminoma

Question 18

malignant germ cell tumor common in adolescents
sheets of uniform “fried egg” cells

Answer 18

dsygerminoma

Question 19

tumor marker:
increased hCG

Answer 19

choriocarcinoma

(can cause precocious puberty if occurring in children)

Question 20

very hemorrhagic cut surface
cytotrophoblasts and syncytiotrophoblasts
blood lakes

Answer 20

choriocarcinoma

Question 21

tumor marker: AFP

Answer 21

yolk sac tumor (endodermal sinus tumor)

Question 22

yellow, hemorrhagic mass
Schiller-Duval bodies
reticular pattern

Answer 22

yolk sac tumor (endodermal sinus tumor)

Question 23

benign
bundle of spindle shaped fibroblasts

Answer 23

fibroma

Question 24

ovarian fibroma
ascites
pleural effusion

Answer 24

Meigs syndrome

(pulling sensation in groin)

Question 25

tumor marker: inhibin

Answer 25

granulosa cell tumor

(used for both diagnosis and monitor for recurrence)

Question 26

most common malignant sex cord stromal tumor

Answer 26

granulosa cell tumor

Question 27

presents with postmenopausal bleeding, endometrial hyperplasia, sexual precocity (in children), and breast tenderness

Answer 27

granulosa cell tumor

Question 28

coffee bean nuclei
call-exner bodies

Answer 28

granulosa cell tumor

Question 29

resembles testicular histology with tubules/cord lined by pink Sertoli cells
Leydig cells with circles of Reinke
may produce androgens and cause hirsutism

Answer 29

Sertoli-Leydig cell tumor

Question 30

most cases of pseudomyxoma peritonei are secondary to […] neoplasms

Answer 30

appendiceal mucinous

Question 31

tumor cells floating in pool of mucin

Answer 31

mucinous carcinoma

Question 32

tubulocystic growth pattern and clear cells

Answer 32

clear cell carcinoma

Question 33

large vesicular cells w/ clear cytoplasm
well defined cell boundaries
centrally placed nuclei
lymphocytes

Answer 33

dysgerminoma

Question 34

painful heavy periods
irregular periods
hemorrhagic cystic lesion

Answer 34

endometriotic cyst

(chocolate cyst,

Question 35

asymptomatic expansion of grafiaan follicle

thin walled, unilocular

Answer 35

follicular cyst

Question 36

menstrual irregularities
palpable abdominal mass
failure to regress after release of ovum

Answer 36

corpus luteum cyst

(she noted the adipose tissue in image)

Question 37

associated with increased risk of endometrioid and clear cell malignancy

Answer 37

endometriotic cyst

Question 38

Answer 38

PCOS

Question 39

tumor marker CA125

Answer 39

serous carcinoma