B8-001 Infertility Flashcards

1
Q

women over […] qualify for immediate fertility evaluation

A

40

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2
Q

[…] is most predictive of fertility

A

maternal age

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3
Q

the egg is typically fertilized in the […] of the fallopian tube

A

ampulla

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4
Q

when is the embryo implanted in IVF?

A

day 6-7

(when it would physiologically be in the uterus preparing for implantation)

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5
Q

indications for ovarian reserve testing [5]

A

greater than 35 yo
tobacco use
prior ovarian surgery
prior gonadotoxin exposure
primary relative with POI

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6
Q

test most indicated for uterine/fallopian tube abnormalities

A

hysterosalpingogram (HSG)

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7
Q

pathogens causing tubal infertility

A

chlamydia
gonorrhea
TB (worldwide)

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8
Q

critical window for male abstinence allowing for proper evaluation of sperm

A

2-5 days between ejaculates

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9
Q

if primary semen analysis is abnormal, what is the recommendation?

A

lifestyle changes

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10
Q

if repeat semen analysis is abnormal, what is the recommendation?

A

labs looking at testosterone, prolactin, estrogen, LH, FSH

urology consult for anatomical issues

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11
Q

low sperm concentration/count

A

oligospermia

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12
Q

low sperm motility

A

asthenospermia

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13
Q

low/abnormal sperm morphology

A

teratospermia

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14
Q

a basic pH of the semen can indicate

A

GU infection

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15
Q

a acidic pH of the semen can indicate

A

obstructive azoospermia or blocked seminal vesicles

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16
Q

normal volume for semen analysis

A

> 1.5 mL

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17
Q

normal pH for semen analysis

A

7.2-8.0

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18
Q

normal concentration for semen analysis

A

greater than 15 million

(consider length of abstinence)

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19
Q

normal motility for semen analysis

A

greater than 39%

(lower indicates membrane issue)

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20
Q

normal total motile sperm for semen analysis

A

greater than 40 x 10^6

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21
Q

normal vitality for semen analysis

A

greater than 75%

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22
Q

normal morphology for semen analysis

A

greater or equal to 4%

23
Q

normal WBC for semen analysis

A

less than 1 million

(higher indicates chronic inflammation)

24
Q

treatment of male infertility with a sperm count greater than or equal to 10 million

A

intrauterine insemination

25
Q

treatment of male infertility with a sperm count less than 10 million

A

IVF or ICSI

26
Q

treatment of male infertility due to low motility

A

NECA via IUI

NECA stimulates sperm motility

27
Q

treatment of male infertility due to anti-sperm antibodies

A

chymotrypsin/galactose via IUI

28
Q

treatment of male infertility due to poor liquefaction

A

chymotrypsin/chymotrypsin inhibitor via IUI

29
Q

most common reversible cause of male infertility

A

varicocele

(swelling of veins that drain the testes)

30
Q

pathogens causing epididymitis/orchitis
[2]

A

gonorrhea
HIV

31
Q

causes of retrograde ejaculation

A

diabetes
spinal injuries
medications
GU surgery

32
Q

the presence of fructose indicates a […] origin of azoospermia

A

testicular

33
Q

absence of fructose and sperm in semen analysis indicates

A

absence of seminal vesicles, vas defrens, or obstruction

34
Q

chromosomal causes of male infertility [4]

A

klinefelters
cystic fibrosis
kallmann’s syndrome
kartagener’s syndrome

35
Q

aromatase inhibitor

A

letrozole

36
Q

SERM

A

clomiphene citrate

37
Q

approved for estrogen + breast cancer

A

letrozole

38
Q

estrogen agonist on ovaries
antagonist on uterus

A

clomiphene citrate

39
Q

adverse effects of clomiphene citrate [3]

A

hot flashes
mood swings
increased risk of multiples

40
Q

treatment for male factor or unexplained fertility

A

IUI

41
Q

direct testing of embryos for single, inherited genetic disease

A

preimplantation genetic testing for monogenic disease (PGT-M)

42
Q

direct testing of IVF embryos for numeric chromosome abnormalities

used in women of AMA and recurrent pregnancy loss

A

preimplantation genetic testing for aneuploidy (PGT-A)

43
Q

asthenospermia means…

A

low motility, less than 39%

44
Q

oligospermia means…

A

low concentration

less than 15,000/ml

45
Q

prolonged abstinence will negatively affect […] of sperm in semen analysis

A

motility

46
Q

[…] is secreted from the seminal vesicles, and will reveal if lack of sperm is at the level of the seminal vesicles

A

fructose

47
Q

first line therapy for fertility therapy in women with PCOS

A

aromatase inhibitor (letrozole)

48
Q

[…] are effective in ovulation induction in PCOS but are not first line as the risk of multiple gestation pregnancy is significantly higher

A

gonadotropins

49
Q

viable option for PCOS related infertility that has not responded to pharmacotherapy

A

ovarian drilling

50
Q

most common presentation for women with hydrosalpinx

A

infertility

51
Q

best management for infertility in a patient with Turner’s syndrome

A

donor oocytes after cardiac clearance

(turner’s patients have increased risk of aortic rupture that doubles with pregnancy due to increased blood volume)

52
Q

first line therapy in women with WHO 1 amenorrhea

A

behavioral modification

53
Q

resumption of menses may take up to […] in women with WHO 1 amenorrhea following behavioral modification

A

18 months