autoimmune hepatitis Flashcards
1
Q
what is autoimmune hepatitis?
A
-inflammatory liver disease of unknown cause characterised by abnormal T cell function and autoantibodies
2
Q
what are the different types of autoimmune hepatitis?
A
- Type 1
- Type 2
3
Q
who does Type 1 autoimmune hepatitis usually affect?
A
-females 10-30 years or >40
4
Q
who does Type 2 autoimmune hepatitis usually affect?
A
-children
5
Q
symptoms of autoimmune hepatitis?
A
- Autoimmune signs (e.g. fever, malaise, rash, polyarthritis..)
- gradual onset of jaundice
- some may be asymptomatic
6
Q
what are the signs of type 1 autoimmune hepatitis?
A
+ve ASMA (anti smooth muscle antibody)
+ve ANA (antinuclear antibody)
increase in IgG
7
Q
what are signs of type 2 autoimmune hepatitis?
A
+ve LKM1
+ve ASMA
-ve ANA
8
Q
treatment for autoimmune hepatitis?
A
IMMUNOSUPPRESSIVE THERAPY
- prednisolone to induce remission
- azathioprine to maintain remission
Liver transplant for cirrhosis
