ASTHMA

Question 1

GINA definition of asthma:

heterogenous disease
variable expiratory airflow
varied symptoms
wheezing
SOB
cough

Answer 1

asthma

Question 2

demographics of astma?

Answer 2

occupational exposures
exercise induced asthma
eosinophilic asthma
ASA exacerbated

Question 3

asthma coexists with?

Answer 3

allergic rhinitis
GERD
obesity

Question 4

major pathophysiology of asthma?

Answer 4

increased smooth muscle mass

airway hyper responsiveness

inflammation

reversible airflow obstruction

Question 5

symptoms of asthma?

Answer 5

SOB
wheezing
cough

Question 6

most common finding on physical exam?

Answer 6

wheezing

Question 7

DDx with asthma?

Answer 7

CHF
COPD
cardiomyopathies
malignancy

Question 8

normal FEV1/FVC is what?

Answer 8

0.7 and 0.8

Question 9

asthma would be represented as an obstructive disease with FEV1/FVC of?

Answer 9

less than .70

Question 10

if asthma is suspected but spirometry is normal what can we do?

Answer 10

bronchoprovocation

methacholine inhalation
exercise testing

Question 11

proper diagnosis of asthma?

Answer 11

symptoms: cough, wheezing, SOB

PE: wheezing

objective data: spirometry

Question 12

GINA recommendations for asthma?

Answer 12

controller

reliever

Question 13

what are the inhaled corticosteroids?

Answer 13

fluticasone
budesonide
beclamethasone
mometasone

Question 14

steps for asthma, 1 and 2?

Answer 14

low dose ICS formoterol taken as needed for symptom relief

Question 15

steps for asthma, 3?

Answer 15

low dose ICS-formoterol for maintenance and reliever tx

Question 16

steps for asthma, 4?

Answer 16

medium dose ICS-formoterol as maintenance and reliever therapy

Question 17

steps for asthma, 5?

Answer 17

HD ICS-formoterol

alternative: ICS-LABA+LAMA, triple agents, biologic therapy

Question 18

what Anti-IgE antibody can be used?

for severe asthma?

Answer 18

Omalizumab

Mepolizumab
Reslizumab
Benralizumab
Dupilumab

Question 19

SABAs can be used for acute episodes of wheezing? T/F

with symptoms than what?

Answer 19

T, severe exacerabations can result

ICS-formoterol, if make it to steps 3-5 than used as maintenance and reliever

Question 20

aspirin induced respiratory disease (AERD) is a triad of?

Answer 20

asthma

chronic rhinosinusitis w polyps

sensitivity to ASA
*block anti-inflammatory PG, LT receptors now unopposed

Question 21

LT mediate?

triggered?

name a LT receptor antagonist?

Answer 21

bronchoconstriction
mucus hypersecretion
mucosal edema

cold air
viral infections
occupational exposure

Montelukast (singular)