Antiemetics Flashcards
1
Q
Mechanism of action
A
Selective binding to receptors in vomiting center of brain => block GI, diaphragm, abdo muscle stimulation
2
Q
What are the 5 main drug classes
A
Antimuscarinics/antihistamines Dopamine receptor antagonists Glucocorticoids Seretonin receptor antagonists Neurokinin receptor antagonists
3
Q
When would you use antimuscarinics/antihistamines
A
Vestibular issues - motion sickness, vertigo
Can be used for N+V caused by many underlying conditions - cyclizine
4
Q
When would you use dopamine receptor antagonists
A
Most commonly used - metoclopramide, domperidone, chlorpromazine
Post op nausea
Motion sickness
5
Q
When would you use glucocorticoids
A
Chemo induced
6
Q
When would you use seretonin receptor antagonists
A
Acute gastroenteritis
Post op nausea
GOLD STANDARD radio/chemo induced N+V - ondansetron
7
Q
When would you use neurokinin receptor antagonists
A
Radio/chemo induced N+V
Post op nausea
