Antiemetic and antinausea drugs Flashcards
What are the seven drugs that are used to treat nausea and vomiting?
Anticholinergic drugs, antihistamines, antidopaminergic, neurokinin, prokinetic, serotonin, and tetrahydrocannabinoid drugs.
What is a drug example of anticholinergic drugs?
Scopolamine
What is the MOA of antihistamine drugs?
It inhibits bidning of acteylcholine to H1 receptors to prevent vomiting
WHat are the two main examples of antihistamine drugs?
Dimenhydrinate and diphenhydramine
What is the main drug example of antidopaminergic drugs?
Prochlorperazine
What is the main drug example for neurokinin receptor antagonists
Aprepitant
What is the MOA of prokinetic drugs and what is the primary example?
Desensitizes CTZ to impulse of GI tract. The main example is metoclopramide
What are serotonin blockers used for, and what is an example?
They are used to treat vomiting and nausea in chemo patients and postoperatively.
What is the MOA of tetrahydrocannabinoids and what is the main example?
It alters the body’s perception of the environment, which can help relieve nausea and vomiting. The main example is medical marijuana
What are three miscellaneous drugs used to treat nausea and vomiting?
Aprepitant, doxylamine succinate, and ginger
What is a serious side effect of most of these drugs?
These drugs may cause drowsiness
What is the most significant contraindication for anticholinergics and antihistamines?
Glaucoma
What is a unique responce older adults and kids have to dimenhydrinate?
Older adults will become sleepy and sluggish while kids will become very energetic
What is a contraindication for antidopaminergic drugs?
Orthostatic hypotension
What is an important drug interaction for neurokinin receptor antagonists?
They increase warfarin metabolism
