Antibiotics Flashcards
1
Q
What Antibiotics Target Nucleic Acid Synthesis?
A
Trimethoprim and Sulphamethoxazole - co-trimoxazole and trimethoprim
Fluoroquinolones - Ciprofloxacin
2
Q
What Antibiotics Target Protein Synthesis?
A
Aminoglycosides - gentamycin
Oxazolidines - linezolid
Macrolides and Tetracyclines - erythromycin, clarithromycin, tetracyclines
Cyclic Lipopeptide - daptomycin
3
Q
What Antibiotics Target Cell Wall Synthesis?
A
Penicillins and Cephalosporins
Glycopeptides - vancomycin and teicoplanin
4
Q
Fluoroquinolones
A
- inhibit nucleic acid synthesis
- ciprofloxacin
- effective against gram negative
- not suitable for children
5
Q
Trimethoprim and Sulphamethoxazole
A
- inhibits nucleic acid synthesis
- used in a combined form (co-trimoxazole)
- trimethoprim commonly used for UTIs
6
Q
Cyclic Lipopeptide
A
- inhibits protein synthesis
- good for gram positives in general and MRSA
7
Q
Oxazolidines
A
- inhibit protein synthesis
- treats MRSA as a last resort
8
Q
Macrolides & Tetracyclines
A
- inhibit protein synthesis
- erythromycin, clarithromycin and the tetracyclines
- alternatives to penicillin in gram positive infections
9
Q
Aminoglycosides
A
- inhibit protein synthesis
- Gentamycin
- treat gram negative
- staphylococci are sensitive
- streptococci are not
10
Q
Glycopeptides
A
- inhibit cell wall synthesis
- only work on gram positive bacteria
- given parenterally (not IV)
- Vancomycin is toxic
11
Q
Penicillins And Celphalosporins
A
- Beta Lactams
- Inhibit cell wall synthesis (peptidoglycan synthesis)
- Many gram negative organisms are resistant
- fusidic acid when combined with flucloxacillin treats staphylococcus infections
