Anterior and posterior pituitary

Question 1

Which hormones are made in the hypothalamus and released by the posterior pituitary?

Answer 1

ADH and oxytocin

Question 2

Where are the posterior pituitary hormones made?

Answer 2

Supraoptic and paraventricular nuclei of hypothalamus

Question 3

What are the differences between GH and IGFs?

Answer 3

GH - short half life (IGFs - long half life)

Question 4

Where is GH produced? IGFs?

Answer 4

1. Somatotropes of anterior pituitary 2. Liver

Question 5

What is the stimulus for the milk let down reflex?

Answer 5

Release of oxytocin in response to infant suckling

Question 6

How does GH impact bone growth?

Answer 6

Stimulates osteoblasts

Question 7

What is POMC?

Answer 7

Propriomelanocortin - becomes hydrolyzed to form ACTH

Question 8

What is the main effect of ACTH?

Answer 8

Stimulation of cortisol synthesis and secretion

Question 9

What is the defect in neurogenic diabetes insipidus?

Answer 9

Hypothalamus or connection between hypothalamus and posterior pituitary (production or release of ADH) - large amounts of dilute urine produced since ADH cannot cause production of concentrated urine

Question 10

What is the defect in nephrogenic diabetes insipidus?

Answer 10

Kidneys (eg V2 receptor on collecting ducts, aquaporin insertion)