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Year 1 Physiology > Gastric secretions > Flashcards

Gastric secretions Flashcards

1
Q

what cell is the source of HCl?

A

parietal cell

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2
Q

what cell is the source of intrinsic factor?

A

parietal cell

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3
Q

what cell is the source of pepsinogen?

A

chief cell

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4
Q

what cell is the source of mucus and bicarb?

A

superficial epithelial cell

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5
Q

what cell is the source of histamine in the GI tract? what is the function of histamine in the GI tract?

A
  1. ECL cells 2. promotes HCl secretion
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6
Q

what cell is the source of gastrin secretion? what is the function of gastrin in the GI tract?

A
  1. G cell 2. promote HCl secretion
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7
Q

what cell is the sourse of Ach secretion? what is the function of Ach in the GI tract?

A
  1. nerve cell 2. promote mucus / bicarb / HCl secretion
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8
Q

what cell is the source of somatostatin? what is the function of somatostatin in the GI tract?

A
  1. D cells 2. suppress HCl secretion
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9
Q

what cells are found in the body of the stomach?

A

parietal, chief, neck, ECL

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10
Q

what cells are found in the antrum of the stomach?

A

chief, endocrine (G and D cells)

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11
Q

what cells are found throughout the entire stomach?

A

superficial epithelial cells

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12
Q

what are the two types of gastric secretions?

A

sodium rich from non-parietal cells and proton rich from parietal cells

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13
Q

acid secretion is regulated through which pathways?

A
  1. paracrine (histamine) 2. endocrine (gastrin) 3. neuronal (Ach)
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14
Q

what is the function of PGs in relation to acid secretion?

A

inhibit acid secretion (paracrine)

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15
Q

how do gastrin and Ach indirectly stimulate acid secretion?

A

via stimulation of gastrin-producing G cells and histamine-producing ECL cells, respectively

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16
Q

what hormone turns off acid secretion?

A

somatostatin

17
Q

where does intrinsic factor bind vitamin B12?

A

duodenum

18
Q

what is the primary signal for pepsinogen secretion?

A

Ach

19
Q

what is the neurocrine signal for mucus secretion? paracrine signal?

A

1 .Ach 2. PGs

20
Q

what are the roles of PGs in the GI tract?

A
  1. mucus and bicarb secretion 2. suppression of HCl secretion 3. increased gastric blood flow

Year 1 Physiology (66 decks)

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