Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CVR Biweekly 1 > Angiogenesis > Flashcards

Angiogenesis Flashcards

1
Q

4 different phases of wound healing

A
  1. coagulation
  2. inflammatory
  3. proliferative
  4. remodeling
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

relating to blood/blood vessels

A

angio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

genesis:

A

beginning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

angiogenesis essentially develops from what

A

existing blood vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

2 examples of normal angiogenesis seen in adults

A
  1. uterine lining
  2. cut on finger (tissue of finger)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

patients with _____ have a lack of angiogenesis

A

diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

angiogenesis is necessary in 3 circumstances:

A
  1. stroke
  2. myocardial infarction
  3. incision repair
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

primary cell type involved in angiogenesis

A

endothelial cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what type of cell is very responsive to hypoxia (low O2 levels)

A

endothelial cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

tight junctions between endothelial cells will be the same or different in different organs

A

different

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

these are precursors to vascular smooth m. cells and provide cellular support, form structural component to support vessel

A

pericytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

first step in angiogenesis (general)

A

VEGF binds to receptors on endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

factors involved in step 1 of angiogenesis that bind to VEGFR1 (Flt-1)

A

PlGF (placental growth factor)
VEGF-A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

main receptor VEGF-A binds to that causes it to have its primary effect

A

VEGFR-2 (Flk-1/KDR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

factor that binds VEGFR3 and drives lymphatic formation

A

VEGF-C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

stimulates proliferation of endothelial cells (this process is selective for EC’s)

A

VEGF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

another factor involved in step 1 of angiogenesis that drives proliferation of endothelium

A

bFGF (basic fibroblast growth factor)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

ultimately induces gene expression and endothelial cell proliferation that drives angiogenesis

A

VEGF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what causes hypoxia in a wound (edge effect)

A

bleeding (losing RBC’s that carry O2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what induces angiogenic factor production to get the angiogenesis process started

A

hypoxia

20
Q

______ drives HIF-alpha and ultimately VEGF expression

A

hypoxia

21
Q

basement membrane degradation/formation of new matrix is what step in angiogenesis

A

step 2

22
Q

main drivers of chewing up old matrix and setting down new matrix

A

MMP’s (matrix metalloproteins)

23
Q

collagenase and degrades collagen I, II, III

A

MMP-1

24
Q

gelatinase and degrades type IV collagen (packman)

A

MMP-2

25
Q

gelatinase and degrades type IV and V collagen

A

MMP-9

26
Q

directional migration and attaching of new matrix is what step in angiogenesis

A

step 3

27
Q

_____ binds vitronectin, fibronectin, and fibrin (the components of new matrix) + MMP-2

A

integrins

28
Q

____ highly expressed on ECs exposed to VEGF and bFGF

A

avB3

29
Q

factors used in step 4 of angiogenesis (blood vessel differentiation and stabilization)

A

Ang-1 and 2
Ephrins

30
Q

factor used for stabilization of angiogenic vessel and has preference for binding of Tie2/Tie2 homodimer

A

Ang-1

31
Q

released in step 4 to help vessel form a tube

A

Ang-1

32
Q

natural inhibitor of Ang-1 (released when Ang-1 no longer needed)

A

Ang-2

33
Q

factor used in loop formation and differentiation of artery or vein

A

Ephrin-B

33
Q

receptor Ephrin binds to

A

EphB

34
Q

expressed on arterial cells

A

Ephrin B

35
Q

expressed on venous cells

A

EphB

36
Q

factor that recruits pericytes in last step (pericytes used for vascular stabilization)

A

Platelet derived growth factor (PDGF)

37
Q

what happens when vessel is stabilized

A

blood flow restored; hypoxia goes away

38
Q

excessive angiogenesis due to severe hypoxia is seen in diabetic patients and can ultimately lead to vision loss

A

diabetic retinopathy

39
Q

if you cut off blood supply to tumor what can happen

A

kill the tumor

40
Q

compared to normal angiogenesis and normal vessels, what are tumor vessels like

A

tortuous (no structure)
leaky vessels

(opposite of normal and stable)

41
Q

cancer cells allow tumor to survive by recruiting what

A

new blood vessels and feeding itself

42
Q

-mab that neutralizes VEGF; used for colorectal cancer

A

Bevacizumab (Avastin)

43
Q

-nib that inhibits epidermal growth factor receptor so no VEGF is made

A

Gefitinib

44
Q

-nib that is a VEGF receptor inhibitor; used for RCC and GIST

A

Sunitinib

45
Q

in early stage treatment with bevacizumab, what happens

A

it actually stabilizes vessel and allows another drug to be administered and go to tumor and kill it

46
Q

drug that inhibits angiogenesis; inhibits NFkB and promotes apoptosis; SE=sedation; used for multiple myeloma

A

Thalidomide

CVR Biweekly 1 (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions