Age associated physiological and pathological changes Flashcards

1
Q

Cortical bone

A

compact bone

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2
Q

Trabecular bone

A

spongy structure below the compact bone -has mesh works structure of bony bars with many interconnecting spaces containing bone marrow.

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3
Q

4 ways how does the density of the cortical and trabecular bone reduce?

A

1.bone wastage -cause of inactive lifestyle
2.hormonal change with age
3.loss of calcium and minerals with age
4.men-gradual changes in hormones

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4
Q

Osteogenic cell

A

stem cell:can differentiate , proliferate and develop in osetoblasts,osteocytes and osteoclasts

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5
Q

what is the correct order of differentiation from these 3 things- osteocytes, osteoclasts, osteoblasts?

A

1.osetoblasts
2.osteocytes
3.osteoclasts

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5
Q

Osteoblast

A

matrix synthesising cell for bone growth

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6
Q

Osteocyte

A

mature bone cell which maintains the bone matrix

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7
Q

Osteoclast

A

bone resorbing cell -responsible for absorbing and breaking bone cells

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8
Q

bone remodelling

A

process of removing and repairing by generating new cells

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9
Q

osteoporosis

A

condition where bones are weakened, fragile and more likely to break

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10
Q

what are the 3 risk factors which can contribute to osteoporosis?

A

1.age
2.menopause
3 environmental

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11
Q

articular cartilage

A

covers surface of bone which form joints and protects bones from rubbing against each other

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12
Q

how is age and the articular cartilage related?

A

as people age the articular cartilage reduces in thickness causing the rubbing of the 2 bones together

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13
Q

Cartilage

A

made of chondrocytes+ extracellular matrix

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14
Q

Osteoarthritis

A

degenerative arthritis joint disease or wear and tear arthritis

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15
Q

how does osteoarthritis arthritis effect the cartilage?

A

there will be breakdown of the cartilage

16
Q

4 effects/symptoms/signs of osteoarthritis

A

-inflammation
-swelling
-pain
-immovable and fingers become distorted.

17
Q

what are the risk factors osteoarthritis?

A

1.age
2.obesity hormonal balance 3.biomechanical event
4.genetic faxtors

18
Q

Rheumatoid arthritis

A

chronic systemic autoimmune disease where there is abnormal antibody response to a range of proteins, including fibrin, fibronectin

19
Q

how is muscle mass and age related?

A

Muscle mass and strength declines with age

20
Q

what happens to the distribution of muscle fibre type as people age

A

muscle fibre type changes with age

21
Q

what are the 2 types of muscle fibres types?

A

type 1 fibre:small slow contracting muscles.Highly resistant to fatigue with many mitochondira and aerobic enzymes for energy production
-type 2 fibre:larger, faster contracting producing large tension output but fatigue quickly

22
Q

Sarcopenia

A

degenerative loss of skeletal muscle mass and strength associated with age

23
Q

Eccentric hypotrophy

A

volume overload size of left ventricle and chamber increase

24
Q

what happens to cardio myocytes in eccentric hypotrophy as an individual ages?

A

With ageing there is loss of cardio myocytes

25
Q

Physiological hypertrophy

A

during exercise or pregnancy

26
Q

how is the cardiovascular system effected with ageing?

A

reduced sensitivity to sympathetic stimuli which compromises myocardial contractility and pumping ability

27
Q

3 things that show the structure of central nervous system

A

1.decline in brain mass and weight
2.fewer synaptic contracts and nerve cell
3.reduce cerebral blood flow(CBF blood supply to brain in period of time)

28
Q

what are the functions of intellect, verbal skills and mental activity of the central nervous system?

A

Intellect:slower in central processing-takes longer to perform tasks
Verbal skills:gradual decrease in vocab, semantic errors and abnormal prosody
Mental activity:difficulty learning, languages and forgetfulness in non critical areas-doesn’t impair recall of important memories or effect function