Age associated physiological and pathological changes Flashcards
Cortical bone
compact bone
Trabecular bone
spongy structure below the compact bone -has mesh works structure of bony bars with many interconnecting spaces containing bone marrow.
4 ways how does the density of the cortical and trabecular bone reduce?
1.bone wastage -cause of inactive lifestyle
2.hormonal change with age
3.loss of calcium and minerals with age
4.men-gradual changes in hormones
Osteogenic cell
stem cell:can differentiate , proliferate and develop in osetoblasts,osteocytes and osteoclasts
what is the correct order of differentiation from these 3 things- osteocytes, osteoclasts, osteoblasts?
1.osetoblasts
2.osteocytes
3.osteoclasts
Osteoblast
matrix synthesising cell for bone growth
Osteocyte
mature bone cell which maintains the bone matrix
Osteoclast
bone resorbing cell -responsible for absorbing and breaking bone cells
bone remodelling
process of removing and repairing by generating new cells
osteoporosis
condition where bones are weakened, fragile and more likely to break
what are the 3 risk factors which can contribute to osteoporosis?
1.age
2.menopause
3 environmental
articular cartilage
covers surface of bone which form joints and protects bones from rubbing against each other
how is age and the articular cartilage related?
as people age the articular cartilage reduces in thickness causing the rubbing of the 2 bones together
Cartilage
made of chondrocytes+ extracellular matrix
Osteoarthritis
degenerative arthritis joint disease or wear and tear arthritis