Acute and Chronic Inflammation Flashcards
2 Acute Inflammation Outcomes
- Complete resolution
- Connective tissues heals/replaces FIBROSIS
Phagocytosis
-Receptors that…
leucocytes recognise and attaches itself to bacteria or damaged cells
Function on leucocytes
Recognise foreign microbes
- Leucocytes stick to vessel wall of area of damage.
- Neutrophils and Macrophages ingest and kill bacteria, necrotic cells and promotes repair.
Cellular Response
Triggers of inflammation
- Tissue damage
- Foregin body
- Infection
- Ischemia/infraction
- Physical/chem injury
- Immune reaction
What is Acute inflammation?
- Rapid response triggering vascular and cellular reaction
- Vasodilation, inc blood flow, causing redness and heat ERYTHEMA
- Inc permeability, fluid leaving extravascular tissue ODEMA
Outcomes of ?
- Complete resolution
- Healing fibrosis
- Abscess formation
- Chronic inflammation
Acute
Chronic inflammation
- Persistent infection
- Prolonged exposure to toxic agent, lipids, silica, asbestos
- Immune mediated inflame, reaction against host tissue leading to auto-immune diseases
Granulomas
-Cellular attempt to get rid of offending agent, but cannot eradicate
- Strong activation of macrophages and T lymphocytes, leading of injury or normal tissue
- eg TB
Virus, auto-immune diseases lead to what inflammation
Chronic
Infraction, bacterial infec, trauma, burns lead to what inflammation
Acute
Rapid response
Short lived
Neutrophils predominate
Aim is complete resolution
Acute
A splinter would be classed as what type of cause of inflammation?
Foreign body
Rheumatoid arthritis is an example of what
Chronic autoimmune inflammatory disease
Which wbc is dominant is acute inflammation?
Neutrophil
