Acid Base 1 Flashcards
What is a normal [H+] in the blood?
40 nEq/L
If take the -log of this value, get 7.4ish –> where normal blood pH determination comes from
What is the range of normal blood pH?
What is the definition of acidemia and alkalemia?
7.37 - 7.42
Acid: pH < 7.37
Alkalosis: pH > 7.42
Many proteins are [acids or bases].
Bases
What is the pH in the following locaitons in the body?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/303/847/368/q_image_thumb.png?1582720720)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/303/847/368/a_image_thumb.png?1582720733)
pH < […] or pH > […] is incompatible with life.
- 8
- 0
- What are 3 common sources of “acid production” in the body?
- How are each of these sources of acid secreted?
- CO2 (CO2 + H2O <=> H2CO3 <=> H+ + HCO3-) –> exhaled
- From diet (sulfuric and phosphoric acids) –> buffered and secreted in kidney
- Lose HCO3- in stool –> loss of base is equivalent to gain of acid –> buffered and secreted in kidney
- Is H2CO3 a strong or weak acid?
- Is there more H2CO3 or H+ in the blood?
- Weak
- H2CO3
How much acid is produced/ingested daily?
-80mEq
What are the immediate buffering compounds in the extracellular fluid? (Blood)
HCO3-
HPO4-2
What compounds act as buffers in the intracellular fluid?
Organic phosphates
Proteins
Hemoglobin
What are all the ways that we can buffer changes in pH?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/303/851/136/a_image_thumb.png?1582721381)
Where in the body is carbonic anhydrase concentration high?
- renal tubule epithelial cells
- walls of alveoli
- RBC
What is the definition of a buffer?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/303/851/266/a_image_thumb.png?1582721475)
How can you manipulate the hendersen hasselbach eqn to relate to the bicarbonate buffering system using pCO2 and [HCO3-]?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/303/851/380/a_image_thumb.png?1582721668)
pCO2 levels are controlled by the […] and HCO3- levels are controlled by the […]
Lungs
Kidney