ABSITE Review - Meds & Pharm Flashcards
Which administration route will bypass the liver metabolism?
Sublingual and Rectal drugs
T/F: The CNS absorbtion is restricted to nonionized, lipi-soluble drugs.
TRUE
Which protein if responsible of binding drugs?
Albumin (PCNs and warfarin are 90% bound)
What means 0 order kinetics?
Constant amount of drug is eliminated regardless of dose
What means 1st order kinetics?
Drug is eliminated proportionally to dose
How many half lives takes to a drug to reach steady state?
Five
What is the volume of distribution?
Vd = Amount of drug in the body/amount of drug in blood or plasma
What is the bioavailability of a drug?
Fraction of unchanged drug reaching the systemic circulation. Assumed to be 100% for intravenous drugs.
What is tachyphylaxis?
Tolerance after only few doses
What is the potency of a drug?
It is the dose required for effect.
What is the efficacy of a drug?
It is the ability to achieve result without untoward effect.
What consist the phase I microsomal drug metabolism?
Occurs in the hepatic cell endoplasmic reticulum. Consist of demethylation, oxidation, reduction, hydrolysis reactions.
What consist the phase II microsomal drug metabolism?
Glucoronic acid (#1) and sulfates attached (forms water soluble metabolite); often inactive and ready for excretion. Biliary excreted drugs may become deconjugated in intestines with reabsorption, some in active form
Mention the inhibitors of P-450.
Cimetidine, INH, ketoconazole, erythromycin, Cipro, Flagyl, allopurinol, verapamil, amiodarone, MAOIs, disulfiram
Mention the inhibitors of P-450.
Cruciform vegetables, ETOH, insecticides, cigarette smoke, phenobarbital, dilantin, theophylline, warfarin
