ABSITE Review - Antibiotics

Question 1

What is an antiseptic? Mention examples.

Answer 1

Kills and inhitis organism on the body
Examples - Iodophors (betadine): good for GPCs, GNRs and poor fungi
Chlorhexidine gluconate (Hibiclens): good for GPCs, GNRs and fungi

Question 2

What is a disinfectant?

Answer 2

Kills and inhibits organisms on inanimate objects

Question 3

Mention some antibiotics class which MOA is inhibition of cell wall synthesis.

Answer 3

Penicillin, cephalosporins, carbapenems, monobactams, vancomycin

Question 4

Mention some antibiotics class which MOA is inhibition of 30s ribosome and protein synthesis.

Answer 4

Tetracycline, Aminoglycosides (tobramycicn, gentamicin), linezolid

Question 5

Mention some antibiotics class which MOA is inhibition of 50s ribosome and protein synthesis.

Answer 5

Erythromycin, clindamycin, chloramphenicol, Synercid

Question 6

Mention some antibiotics class which MOA is inhibition of DNA helicase.

Answer 6

Quinolones

Question 7

Mention some antibiotics class which MOA is inhibition of RNA polymerase.

Answer 7

Rifampin

Question 8

Mention some antibiotics class which MOA is produce oxygen radicals that breakup DNA.

Answer 8

Metronidazole

Question 9

What is the MC method of antibiotic resistance?

Answer 9

Transfer of plasmids

Question 10

What is the next step if the peak level is too high?

Answer 10

Decrease the amount of each dose

Question 11

What is the next step if the trough level is too high?

Answer 11

Decrease the frequency of doses

Question 12

What is the MOA of amphotericin?

Answer 12

Binds sterols in wall and alters membrane permeability

Question 13

What is a side effect of carbapenems?

Answer 13

Seizures

Question 14

Which antibiotic also binds motilin receptors and is prokinetic for bowel?

Answer 14

Erythromycin

Question 15

What is the timeframe for perioperative antibiotics?

Answer 15

need to be given within 2 hours before incision

Question 16

Review coverage of abxs

Answer 16

Pages 26-29