A&P Chapter 2 Flashcards
The body is made up of many ______
Chemicals
Chemistry underlies all ______ reactions
Physiological
What are some examples of physiological reactions?
Movement, digestion, pumping of the heart, and nervous system
Chemistry can be broken down into what two categories?
- Basic chemistry
- Biochemistry
What is matter?
Anything that has mass and occupies space
Matter can be:
1. _______
2. _______
and/or
3. _______
Seen, smelled, felt
Weight is _____ + the effects of what?
Mass + the effects of gravity
What are the three possible states that matter can exist in?
- Solid
- Liquid
- Gas
What are characteristics of a solid?
Definite shape and volume
What are characteristics of a liquid?
Changeable shape; definite volume
What are characteristics of a gas?
Changeable shape and volume
What is energy?
The capacity to do work or put matter into motion
What are the two possible forms of energy?
Kinetic and potential
What is kinetic energy?
Energy in action
What is potential energy?
Stored (inactive) energy
Energy can be transformed from ______ —> what?
Potential —> kinetic energy
Stored energy can be ______, resulting in action
Released
All matter is composed of what?
Elements
4 elements make up what percentage of the body and what are they?
96% of the body is made up of carbon, oxygen, hydrogen, and nitrogen
9 elements make up how much of the body?
3.9%
11 elements make up how much of the body?
<0.01%
The periodic table lists what elements?
All known
What are all elements made up of?
Atoms
What are atoms?
- Unique building blocks for each element
- Smallest particles of an element with properties of that element
- What gives each element its particular physical and chemical properties
What is an atomic symbol?
One or two letter chemical shorthand for each element
What is an example of an atomic symbol?
O for oxygen
What is another example of an atomic symbol?
C for carbon
How are atomic symbols determined?
Some symbols come from Latin names
What is an example of an atomic symbol being named after latin names?
Na = Sodium (Natrium)
What is another example of an atomic symbol being named after latin names?
K = Potassium (Kalium)
What is the atomic symbol for oxygen?
O
What is the approximate percentage of body mass that oxygen makes up?
65%
What is the function of oxygen in the body?
A component of both organic and inorganic molecules. As a gas, it is needed for the production of cellular energy (ATP)
What is the difference between organic and inorganic molecules?
Organic = Carbon containing
Inorganic = Non-carbon containing
What is the atomic symbol for carbon?
C
What is the approximate percentage of body mass does carbon make up?
18.5%
What is the function of carbon in the body?
A component of all organic molecules, which include carbohydrates, lipids, proteins, and nucleic acids
What are lipids?
Fats and oils
What is the atomic symbol for hydrogen?
H
What is the approximate percentage of body mass does hydrogen make up?
9.5%
What is the function of hydrogen in the body?
A component of all organic molecules. As an ion (proton), it influences the pH of body fluids
What is the atomic symbol for nitrogen?
N
What is the approximate percentage of body mass does nitrogen make up?
3.2%
What is the function of nitrogen in the body?
A component of proteins and nucleic acids
What is the atomic symbol for calcium?
Ca
What is the approximate percentage of body mass that calcium makes up?
1.5%
What is the function of calcium in the body?
Found as a salt in bones and teeth. It’s ionic form is required for muscle contraction, conduction of nerve impulses, and blood clotting.
What is the ionic form of calcium?
Ca2+
What is the atomic symbol for phosphorus?
P
What is the approximate percentage of body mass that phosphorus makes up?
1%
What is the function of phosphorus in the body?
Part of calcium phosphate salts in bones and teeth. Also present in nucleic acids, and as a part of ATP and phospholipids
What is the atomic symbol for potassium?
K
What is the approximate percentage of body mass does potassium make up?
0.4%
What is the function of potassium in the body?
Its ion is the major positive ion in cells. Necessary for conduction of nerve impulses and muscle contraction
What is a positive ion called?
Cation
What is a potassium ion?
K+
What is the atomic symbol for sulfur?
S
What is the approximate percentage of body mass that sulfur makes up?
0.3%
What is the function of sulfur in the body?
Components of proteins, particularly muscle proteins
What is the atomic symbol for sodium?
Na
What is the approximate percentage of body mass that sodium makes up?
0.2%
What is the function of sodium in the body?
As an ion, sodium is the major positive ion found in extracellular fluids. Important for water balance, conduction of nerve impulses, and muscle contraction
What is a sodium ion?
Na+
What is extracellular fluid?
Fluid outside the cell
What is the atomic symbol for chlorine?
Cl
What is the approximate percentage of body mass that chlorine makes up?
0.2%
What is the function of chlorine in the body?
Its ion is the most abundant negative ion in extracellular fluids
What is a negative ion called?
Anion
What is a chlorine ion?
Chloride, Cl-
What is the atomic symbol for magnesium?
Mg
What is the approximate percentage of body mass that magnesium makes up?
0.1%
What is the function of magnesium in the body?
Present in bone. Also an important cofactor in a number of metabolic reactions
What is the atomic symbol of iodine?
I
What is the approximate percentage of body mass that iodine makes up?
0.1%
What is the function of iodine in the body?
Needed to make functional thyroid hormones
What is the atomic symbol for iron?
Fe
What is the approximate percentage of body mass that iron makes up?
0.1%
What is the function of iron in the body?
Component of hemoglobin and some enzymes
What does hemoglobin do?
Transports oxygen within red blood cells
Atoms are composed of 3 subatomic particles, what are they?
- Protons
- Neutrons
- Electrons
What do protons carry?
A positive charge (+)
How much does a proton weigh?
An arbitrary 1 atomic mass unit (1 amu)
What do neutrons carry?
No electrical charge (0)
How much does a neutron weigh?
1 amu
What do electrons carry?
A negative charge (-)
How much does an electron weigh?
Virtually nothing because they are so small (0 amu)
The orbital model represents electrons as what?
A cloud of negative charge
The more simplified planetary model shows electrons as what?
Two small spheres on a circle around the nucleus
Different elements contain different numbers of what?
Subatomic particles
Hydrogen has _ proton, _ neutrons and _ electron
1 proton, 0 neutrons, 1 electron
Helium has _ protons, _ neutrons, and _ electrons
2 protons, 2 neutrons, 2 electrons
Lithium has _ protons, _ neutrons, and _ electrons
3 protons, 4 neutrons, and 3 electrons
How can you identify elements?
Atomic number and mass number
How is the atomic number determined?
Number of protons in the nucleus
How is an atomic number written?
As a subscript to the left of the atomic symbol (think denominator)
How is the mass number determined?
Total number of protons and neutrons in the nucleus, aka total mass of the atom
How is the mass number written?
As a superscript to the left of atomic symbol (think numerator)
What are isotopes?
Structural variations of the same element
Atoms contain the same number of _____ but differ in the number of _____ they contain
Same number of protons but differ in the number of neutrons they contain
So, in isotopes, atomic numbers are _____, but mass numbers are ______
Atomic numbers are the same, but mass numbers are different
What is an atomic weight?
Average of mass numbers of all isotope forms of an atom
What are radioisotopes?
Isotopes that decompose to more stable forms
In radioisotopes, the atom loses what?
Varius subatomic particles
When an atom loses subatomic particles, such as in radioisotopes, what can happen to the isotope?
Can become a different element
What is radioactivity?
As the isotope decays, subatomic particles that are being given off release a little energy. The energy is called radioactivity
What can radioactivity do?
Damage living tissue to cause or treat cancer
Radioactivity can be detected and measured by what?
Scanners
Most atoms chemically combine with other atoms to form ______ and _______
Molecules and compounds
What is a molecule?
General term for 2 or more atoms bonded together
What is a compound?
Specific molecule that has 2 or more different kinds of atoms bottom together
What is an example of a compound?
C6H1206
Molecules with only one type of atom, like H2 or O2 are called what?
Molecules
What are chemical bonds?
Energy relationships between electrons of reacting atoms
What are chemical bonds not?
Not actual physical structures
What are the subatomic particles that are involved in all chemical reactions?
Electrons
What do electrons determine?
Whether a chemical reaction will take place and if so, what type of chemical bond is formed
Electrons can occupy areas around the nucleus called what?
Electron shells
Each electron shell contains electrons that have a certain amount of kinetic and potential energy, so shells are also called what?
Energy levels
Depending on the size of an atom, how many electron shells can an atom have?
Up to 7
Shells can only do what?
Hold a specific number of electrons
Which shell is filled first?
The one closest to the nucleus
Shell one can hold only _ electrons?
2
Shell 2 holds a maximum of how many electrons?
8
Shell 3 holds a maximum of how many electrons?
8
The outermost electron shell is called what?
Valence shell
Electrons in the valence shell have the most ______ energy and why?
Potential energy because they are the farthest from the nucleus
Which electrons are involved in chemical reactions?
Valence shell electrons
What is the Octet rule/rule of 8th’s?
Atoms desire 8 electrons in their valence shell
What are exceptions to the Octet rule?
Smaller atoms like H and He, they want only 2 electrons in shell 1
The desire to have 8 electrons is the driving force behind what?
Chemical reactions
What is special about noble gases?
They already have the full 8 valence electrons (or 2 electrons for He), so they are not chemically reactive
Most atoms ____ ____ have full valence shells
Do not
Atoms will _____, _____, or ___ electrons (aka form bonds) with other atoms to achieve stability of 8 electrons in the valence shell
Gain, lose, or share
What are chemically inert elements?
Valence shell is complete
What are 2 examples of chemically inert elements?
- Helium (He) 2p, 2n, 2e
- Neon (Ne) 10p, 10n, 10e
What are chemically reactive elements?
Valence shell is incomplete
What are examples of chemically reactive elements?
- Hydrogen (H) 1p, 0n, 1e
- Carbon (C) 6p, 6n, 6e
- Oxygen (O) 8p, 8n, 8e
- Sodium (Na) 11p, 12n, 11e
What are ions?
Atoms that have gained or lost electrons and become charged
The number of protons ___ ____ equal the number of electrons
Does not
Ionic bonds involve what?
The transfer of valence shell electrons from one atom to another, resulting in ions. One becomes an anion, and one becomes a cation
What is an anion?
Negative charge, the atom that gained one or more electrons
What is a cation?
Positive charge, the atom that lost one or more electrons
The attraction of what results in an ionic bond?
Opposite charges
Most ionic compounds are what?
Salts
What is an example of an ionic compound?
NaCl, sodium chloride
What is an example of the formation of an ionic bond?
Sodium with 1e in the outer shell and chlorine with 7 in the outer shell
1. The lone outer electron of sodium joins the seven outer electrons of chlorine
2. The result is a cation (Na+) and an anion (Cl-), which can form ionic bonds
What are covalent bonds?
Bonds formed by the sharing of two or more valence shell electrons between two atoms
The sharing of 2 electrons results in what kind of bond?
Single
The sharing of 4 electrons results in what kind of bond?
Double
The sharing of 6 electrons results in what kind of bond?
Triple
What do covalent bonds allow?
Allows each atom to fill its valence shell at least part of the time
What are the two types of covalent bonds?
Polar and nonpolar
What are nonpolar covalent bonds?
Equal sharing of electrons between atoms that results in electrically balanced, nonpolar molecules such as CO2
Carbon dioxide molecules are ____ _____, which makes them ______
Linear and symmetrical, makes them nonpolar
What are polar covalent bonds?
Unequal sharing of electrons between 2 atoms, resulting in electrically polar molecules
How does unequal sharing occur?
Atoms have different electron attracting abilities
What is an example of covalent bonds?
The formation of four single covalent bonds: Carbon shares four electron pairs with four hydrogen atoms, and the result looks like a + with C in the middle and H on the 4 sides
What is an example of polar covalent bonds?
V-shaped water (H2O) molecules have two poles of charge, a slightly more negative oxygen end and a slightly more positive hydrogen end
What are hydrogen bonds?
Attractive force between electropositive hydrogen of one molecule and an electronegative atom of another molecule
A hydrogen bond is not a true bond but more of what?
A weak magnetic attraction
What is an example of hydrogen bonds?
The slightly positive ends of the water molecules become aligned with the slightly negative ends of other water molecules
When do chemical reactions occur?
When chemical bonds are formed, rearranged, or broken
Chemical equations contain what 2 things?
Reactants and products
What are reactants?
Substances entering into reaction together
What is the product(s)?
Resulting chemical end products
What is a synthesis reaction?
Smaller particles are bonded together to form larger, more complex molecules
What is an example of a synthesis reaction?
Amino acids are joined together to form a protein molecule
What is a decomposition reaction?
Bonds are broken in larger molecules, resulting in smaller, less complex molecules
What is an example of a decomposition reaction?
Glycogen is broken down to release glucose molecules
What is an exchange reaction/displacement reaction?
Bonds are both made and broken
What is an example of an exchange reaction/displacement reaction?
ATP transfers its terminal phosphate group to glucose to form glucose-phosphate
All chemical reactions are either _____ or _____
Exergonic or endergonic
Exergonic reactions result in what?
A net release of energy (aka it gives off energy)
The products in an exergonic reaction have _____ _____ _____ than reactants
Less potential energy
What is are 2 examples of exergonic reactions?
Catabolic and oxidative reactions
Endergonic reactions result in what?
A net absorption of energy (aka they use up energy)
The products in an endergonic reaction have ____ ____ ____ than the reactants
More potential energy
What is an example of an endergonic reaction?
Anabolic reactions
The speed of chemical reactions can be affected by what and how?
- Temperature = increased temperatures usually increase the rate of reaction
- Concentration of reactants = increased concentrations usually increase rate
- Particle size = smaller particles usually increase rate
What do catalysts do?
Increase the rate of reaction without being chemically changed or becoming part of the product
What are biological catalysts?
Enzymes
What is biochemistry?
The study of chemical composition and reactions of living matter
All chemicals are either ____ or ____
Organic or inorganic
What are some examples of inorganic compounds?
Water, salts, and many acids and bases
Inorganic compounds do not contain what?
Carbon
What are some examples of organic compounds?
Carbohydrates, fats, proteins, and nucleic acids
Organic compounds contain what and what are their characteristics?
Contains carbon, are usually large, and are covalently bonded
Organic and inorganic compounds are both _____ _____ for life
Equally essential
What is the most abundant inorganic compound that accounts for 60-80% of the volume of living cells?
Water
What are the properties of water?
- High heat capacity = ability to absorb and release heat with little temperature change, prevents sudden changes in temperature
- High heat of vaporization = heat is lost with evaporation
- Polar solvent properties = dissolves and dissociates ionic substances (used for transport in the body)
- Reactivity = hydrolysis and dehydration synthesis reactions
- Cushioning
What is an example of water’s high heat capacity?
Water in the blood redistributes head among tissues to maintain homeostasis
What is an example of water’s high heat of vaporization?
Sweat evaporates from skin
What is an example of water cushioning?
Cushing body organs like in CSF
What are salts?
Ionic compounds that dissociate into separate ions in water
Ions play specialized roles in what and is vital for what?
Body functions and is vital for homeostasis
What are common salts in the body?
NaCl, CaCO3, KCl, calcium phosphates
Acids and bases are both _____, so they ionize and dissociate in water?
Electrolytes
Acids are proton _____ and they release ____ _____ (H+) and bare protons in the solution
Donors and they release hydrogen ions
What are important acids?
HCl, HC2H3O2, and H2CO3
What is HCl?
Hydrochloric acid
What is HC2H3O2?
Acetic acid (HAc)
What is H2CO3?
Carbonic acid
Bases are proton ______ and they pick up what type of ions in the solution?
Proton acceptors and they pick up H+ ions
What are bare protons?
Protons that have no electrons
When a base dissolves in solution, what does it release?
Hydroxyl ion (OH-)
What are important bases?
Bicarbonate ion and ammonia
What is HCO3-?
Bicarbonate ion
What is NH3?
Ammonia
On the pH scale, numbers 8-14 are _______ ____
Increasingly basic
On the pH scale number 7 is ____
Neutral
On the pH scale, numbers 6 and below is _____ _____
Increasingly acidic
1M sodium hydroxide has a pH of what?
14 (the most basic)
Oven cleaner, lye has a pH of what?
13.5 (basic)
Household ammonia has a pH of what?
10.5 to 11.5 (basic)
Household bleach has a pH of what?
9.5 (basic)
Egg whites have a pH of what?
8 (the least basic)
Blood has a pH of what?
7.4 (neutral)
Milk has a pH of what?
6.3 to 6.6 (the least acidic)
Black coffee has a pH of what?
5 (acidic)
Wine has a pH of what?
2.5 to 3.5 (acidic)
Lemon juice and gastric juice have a pH of what?
2 (acidic)
1M of hydrochloric acid has a pH of what?
0 (the most acidic)
What is a neutralization reaction?
Acids and bases are mixed together. Displacement reactions occur, forming water and a salt
What is an example of a neutralization reaction?
NaOH + HCl —> NaCl + H20
What are the major organic compounds?
Carbohydrates, lipids, proteins, and nucleic acids
Many organic compounds are ______
Polymers
What are polymers?
Chains of similar unites called monomers
Organic compounds are synthesized by what?
Dehydration synthesis
Organic compounds are broken down by what?
Hydrolysis reactions
What is dehydration synthesis?
Monomers are joined by removal of OH from one monomer and removal of H from the other at the site of bond formation
What is hydrolysis?
Monomers are released by the addition of a water molecule, adding OH to one monomer and H to the other
Carbohydrates include what?
Sugars and starches
What are monosaccharides?
Monomers of carbohudrates
What are some examples of monosaccharides?
Hexose sugars = Glucose, fructose, galactose
Pentose = Deoxyribose and ribose
What are disaccharides?
Consist of two linked monosaccharides
What are some examples of disaccharides?
Sucrose = glucose + fructose
Maltose = glucose + glucose
Lactose = galactose + glucose
What is a polysaccharides?
Long chains (polymers) of linked monosaccharides
What do lipids contain?
C, H, and O, but less than in carbohydrates, and sometimes contain P
Lipids are _____ in water
Insoluble
Triglycerides or neutral fats are called _____ when solid and _____ when liquid
Fats when solid and poils when liquid
What are the main functions of triglycerides/neutral fats?
Energy storage, insulation, protection
What is the triglyceride formation?
Three fatty acid chains are bound to glycerol by dehydration synthesis
The head and tail regions of phospholipids contain different properties, what are they?
Head is a polar region and is attracted to water, tails are nonpolar and are repelled by water
Phospholipids are important in what structure?
Cell membrane
What is the typical structure of a phospholipid molecule?
Two fatty acid chains (tail) and a phosphorus-containing group (head) are attached to the glycerol backbone like in Phosphatidylcholine
What are common steroids?
Natural: cholesterol, vitamin D, steroid hormones, and bile salts
Man-made: Corticosteroids and anabolic
What is the most important steroid and why?
Cholesterol, because it is the basis for all steroids formed in the body and it is important in cell plasma membrane structure
What is the simplified structure of a steroid?
Four interlocking hydrocarbon rings
What are eicosanoids?
Found in cell membranes
What are the most important eicosanoids?
Prostaglandins, because they play a role in blood clotting, control of blood pressure, inflammation, and labor contractions
All proteins are made from __ types of amino acids?
20
All proteins are joined by covalent bonds called ____ bonds
Peptide
Proteins can act as either an ____ or _____
Acid or base
Proteins differ by which of ___ ____ ____ ____ is present
20 different “R groups” is present
What is the primary structure of proteins?
The sequence of amino acids form the polypeptide chain
What is the secondary structure of proteins?
The primary chain forms spirals (alpha helices) and sheets (beta sheets)
What is the tertiary structure of proteins?
Superimposed on secondary structure, alpha helices and/or beta sheets are folded up to form a compact globular molecule held together by intramolecular bonds
What is the quaternary structure of proteins?
Two or more polypeptide chains, each with its own tertiary structure, combines to form a functional protein
What is denaturation?
Globular proteins unfold and lose their functional 3-D shape, and active sites become deactivated
Why does denaturation occur?
Decreased pH (increased acidity) or increased temperature
Is denaturation reversible?
If normal conditions are restored, but is irreversible if the changes are extreme, like how you can’t uncook an egg
What are enzymes?
Globular proteins that act as biological catalysts
What do catalysts do?
Regulate and increase the speed of chemical reactions without getting used up in the process
What do enzymes do to the energy?
Lowers the energy needed to initiate a chemical reaction. Leads to an increase in the speed of a reaction. Allows for millions of reactions per minute
What are nucleic acids?
Largest molecules in the body, composed of C, H, O, N and P
What are nucleic acid polymers made up of?
Monomers called nucleotides, composed of a nitrogen base, a pentose sugar, and phosphate group
What are the two major classes of nucleic acids?
Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA)
What does DNA hold?
The genetic blueprint for the synthesis of all proteins
What is DNA?
A double-stranded helical molecule (double helix) located in the cell nucleus
What do nucleotides contain?
A deoxyribose sugar, phosphate group, and one of four nitrogen bases
What are the 2 groups that the four nitrogen bases fall into?
Purines: adenine (A) and guanine (G)
Pyrimidines: cytosine (C) and thymine (T)
RNA links DNA to ____ _____ and is slightly different from DNA
Protein synthesis
What is RNA?
Single-stranded linear molecule is active mostly outside the nucleus. Contains a ribose sugar
What is thymine replaced with in RNA?
Uracil