A&P Chapter 12 Flashcards
Adult brains have how many regions?
Four
What are the four regions of the adult brain?
- Cerebral hemispheres
- Diencephalon
- Brainstem (Midbrain, pons, medulla)
- Cerebellum
What are ventricles?
Fluid-filled chambers that are continuous to one another and to the central canal of the spinal cord
What are ventricles filled with?
Cerebrospinal fluid (CSF)
What does gray matter contain?
Neuron cell bodies and short nonmyelinated neurons
What does white matter contain?
Mostly myelinated axons and some nonmyelinated axons
What are ventricles lined by?
Ependymal cells (neuroglial cells)
Paired lateral ventricles are what?
Large, C-shaped chambers located deep in each hemisphere
What are the lateral ventricles separated by?
Septum pellucidum
The third ventricle is connected by what?
Interventricular foramen
The fourth ventricle is connected by what?
Cerebral aqueduct
The meninges cover and protect what?
CNS
What are the three layers of meninges (external to internal)?
Dura mater, arachnoid mater, and pia mater
What is the subdural space?
In between the dura and arachnoid mater
What is the subarachnoid space?
In between the arachnoid and pia mater
What does the subarachnoid space contain?
CSF and the largest blood vessels of the brain
What is meningitis?
Inflammation of the meninges primarily due to bacterial or viral infection
If meningitis spreads to the CNS, what could happen?
Inflammation of the brain, referred to as encephalitis
How is meningitis usually diagnosed?
By observing microbes in a sample of CSF obtained via lumbar puncture
What are the symptoms of meningitis?
Fever, headache, vomiting, and stiff neck (more severe with bacterial infection)
Meningitis can result in what if untreated?
Brain damage and death
How can meningitis be prevented?
Vaccine for most common bacterial strains causing meningitis
What does the CSF form?
A liquid cushion of constant volume around the brain
What are the functions of CSF?
- Gives buoyancy to CNS structures (reduces weight of brain by 97% by floating it so it is not crushed under its own weight)
- Protects CNS from blows and other trauma
- Nourishes brain and carries chemical signals
What is the CSF composed of?
Watery solution formed from blood plasma, but with less protein and different ion concentrations from plasma
What is the choroid plexus?
Cluster of capillaries that hangs from roof of each ventricle, enclosed by the pia mater and surrounding layer of ependymal cells
CSF is filtered from the plexus at a ______ rate
Constant
Ependymal cells use ____ -___ to control the composition of CSF and helps cleanse the CSF by removing wastes
Ion pumps
What keeps CSF in motion?
Cilia of ependymal cells
What is the normal adult CSF volume, and how often is it replaced?
~150ml, and is replaced every 8 hours
What is the blood brain barrier?
Helps maintain stable environment for the brain and prevent neuron exposure to harmful substances.
What can pass the blood brain barrier?
Some drugs and alcohol
What are the 3 important features of the blood brain barrier?
- Tight junctions ensure substances pass through, not around endothelial cells
- Feet of astrocytes and smooth muscle-like pericytes surround endothelial cells
- Continuous basement membrane
What do the cerebral hemispheres form?
Superior part of the brain
What percentage of brain mass do the cerebral hemispheres form?
83%
What are the brain surface markings?
Gyri, sulci, fissures (longitudinal and transverse)
What are gyri?
Ridges
What is sulci?
Shallow grooves
What are fissures?
Deep grooves
What is the longitudinal fissure?
Separates two hemisphere
What is the transverse cerebral fissure?
Separates cerebrum and cerebellum
What are the 5 cerebral lobes?
- Frontal
- Parietal
- Temporal
- Occipital
- Insula
What does the frontal lobe do?
Voluntary motor functions, concentration, communication, decision making, planning, and personality
What does the parietal lobe do?
Serves general sensory functions
What is an example of what the parietal lobe does?
Evaluating shape and texture of objects
What does the temporal lobe do?
Hearing and smell
What does the occipital lobe do?
Functions in vision and visual memories
Where is the insula?
Deep to lateral sulcus
What does the insula do?
Functions in memory and sense of taste
What is the cerebral cortex known as?
Executive suite of the brain
What does the cerebral cortex do?
Site of conscious mind: awareness, sensory perception, voluntary motor initiation, communication, memory, storage, and understanding
What is the cerebral cortex composed of?
Thin (2-4mm) superficial layer of gray matter composed from neuron cell bodies, dendrites, glial cells, and blood vessels
What does the cerebral cortex not contain?
Axons
What percentage of brain mass does the cerebral cortex make up?
40%
What are the features of the cerebral cortex?
- Contains three types of functional areas (motor, sensory, association)
- Each hemisphere is concerned with contralateral (opposite) side of body
- Lateralization (specialization) of cortical function can only occur in one hemisphere
- Conscious behavior involves entire cortex in one way or another
What are the three types of functional areas of the cerebral cortex and what do they do?
Motor areas = controls voluntary movement
Sensory areas = conscious awareness of sensation
Association areas = integrate diverse information
What do motor areas of the brain contain?
Primary motor cortex, premotor cortex, frontal eye field, Broca’s area
Where is the primary (somatic) motor cortex?
Located in the precentral gyrus of the frontal lobe
What does the primary (somatic) motor cortex do?
Allows conscious control of skilled voluntary movement of skeletal muscles
What is somatotopy?
All muscles of the body can be mapped to area on the primary motor cortex
What is the motor homunculi?
Upside-down caricatures represents contralateral motor innervation of body regions
What is Broca’s area?
Motor speech area that directs muscles of speech production, also active in planning speech and voluntary motor activities
Where is Broca’s area?
Present in one hemisphere (usually the left)
What does the frontal eye field contain?
Controls voluntary eye movements
Damages to areas of the primary motor cortex (like in a stroke) does what?
Paralyzes muscles controlled by those areas
Paralysis occurs on the _____ side of the body from the damage
Opposite
What is not impaired in damage to the primary motor cortex?
Muscle strength or ability to perform discrete individual movements is not impaired
What is an example of damage to the primary motor cortex?
Damage to the premotor area controlling movement of the fingers would still allow the fingers to move, but voluntary control needed to type would be lost
Other premotor neurons can be _______ to take over the skill of damage neurons?
Reprogrammed
What is FAST for a stroke?
(F)ace drooping
(A)rm weakness
(S)peech difficulty
(T)ime to call 911
What does the sensory areas and related association areas contain?
Primary somatosensory cortex, somatosensory association cortex, gustatory cortex, vestibular cortex, Wernicke’s area, primary visual cortex, visual association area, auditory association area, primary auditory cortex
What does the primary somatosensory cortex recieve?
General sensory information from skin and proprioceptors of skeletal muscle, joints, and tendons
What is the primary somatosensory cortex capable of?
Spatial discrimination
What is spatial discrimination?
Identification of body region being stimulated
What is the somatosensory homunculus?
Upside-down caricature represent contralateral sensory input from body regions
What is lateralization?
Hemispheres are not identical
What is cerebral dominance?
Refers to hemisphere that is dominant for language
What percentage of humans have left-sided dominance?
90%
What does left-sided dominance usually result in?
Right-handedness
The roles of hemispheres are reversed in what percentage of humans?
10%
What does the left hemisphere do?
Controls language, math, and logic
What does the right hemisphere do?
Visual-spatial skills, intuition, emotion, artistic and musical skills
Hemisphere communicates almost instantaneously via what?
Fiber tracts and functional integration
What are the cerebral white matter tracks responsible for?
Responsible for communication between cerebral areas, and between cortex and lower CNS
What does the cerebral white matter tracks consist of?
Myelinated fibers bundled into large tracts
How are cerebral white matter classified?
According to the direction they run
What are the classifications of cerebral white matter?
Association, commissural, and projection fibers
What are association fibers?
Horizontal running fibers that connect different parts of the same hemisphere
What are commissural fibers?
Horizontal fibers that connect gray matter of two hemisphere
What is an example of commissural fibers?
Corpus callosum
What are projection fibers?
Vertical fibers that connect hemispheres with the lower brain or spinal cord
What is Huntington disease?
Hereditary disease affecting the cerebral nuclei
What is the physiology of Huntington’s?
Mutated Huntingtin protein (HTT), which is toxic to neurons
What are some symptoms of Huntington’s?
Rapid, jerky, involuntary movements and intellectual deterioration
What is the prognosis of Huntington’s?
Fatal within 10-20 years after onset
What is the physiology of Parkinson’s disease?
Decreased dopamine production and death of neurons in the substantia nigra
What does Parkinson’s disease affect?
Muscle movement and balance
What are symptoms of Parkinson’s disesase?
Stiff posture, slow voluntary movements, resting tremor
What does the diencephalon contain?
The epithalamus, thalamus, and hypothalamus
What does the diencephalon do?
Provides relays and switching centers for sensory, motor, and visceral pathways
What is the epitalamus?
The most dorsal portion of the diencephalon that forms the roof of the third ventricle
What does the epithalamus contain?
The pineal gland (body)