A&P Chapter 16: Flashcards
Hormones
- paracrine glands, e.g. prostaglandins
- autocrine gland, e.g. interleukins
- exocrine glands, e.g. sweat glands
secrete their products into the body fluid (tissue fluid)
paracrine glands
paracrine glands products affects only the surrounding cells
prostaglandins
secretion affects only the secreted cells
autocrine glands, some interleukins
secrete their products into a duct
exocrine glands
excrine glands ducts transport the secreted products
sweat glands
are considered to be endocrine secretion that produce local hormones
paracrine and autocrine secreations
steroid (or steroid like substances) hormones
are lipid soluble
non-steroid hormones
- amines: amino acids
- peptides: groups of amino acids
- proteins: much longer than peptides
- glycoproteins: carbs and protein
- all are water soluble
complex lipid substance
steroid hormones
derive from chloesterol
steroid hormones
these are lipid soluble compound; easily diffuse through the cell membrane
steroid hormone
combine with the receptors inside the nucleus and activate specific genes to synthesize specific proteins
steroid hormone
such proteins produce special effects or functions – which are the hormonal functions
steroid hormone
vitamin – D is a modified steroid that can be converted into a
hormone (Dihydroxycholecalceferol) to promote absorption of calcium and phosphorus in the gut
steroid hormone
examples of steroid hormones
androgen and estrogen
fat soluble hormones
steroid hormone
process of steroid hormones
Hormone passes through the cell membrane → passes through the cytoplasm → passes through the nuclear membrane → binds to a hormone receptor → binds to the DNA → activates gene →
protein synthesis → Protein action is the hormonal action
water soluble hormones
non-steroid hormones
process of non-steroid hormones
hormones bind to receptor and activate G-protein (hormone is the first messanger→ G protein activates enzyme (Adenylate Cyclase) → adelylate cyclase converts ATP into c-AMP (cyclic adenosine monophosphate) (c-AMP is the 2nd messager) → AMP activates set of enzymes (protein kinases) → Ca2+ is the 3rd messenger
also produced from the adrenal medulla form the amino acids
amines
e.g. triiodothyronine (T-3), thyroxine (T-4)
mostly produced from the hypothalamus and posterior part of the pituitary gland
peptide hormones
e.g. anti-diuretic hormone (ADH): contrict blood vessels blood pressure increase
mostly y produced from anterior part of the pituitary gland and the parathyroid gland
parathyroid hormone (PTH)
there are paracrine secretions; can inflame organs
prostaglandins
these are lipids
prostaglandin
produced by the cells in the liver, kidney, heart, lungs, thymus, pancreas, brain, reproductive organs
prostaglandins
secretions regulate surrounding cells
prostaglandins
actions of hormones
- hormones function by altering metabolic processes
- hormones may reach various different cells in the body, but only binds to the receptors of the target cells
- these receptors are protein and glycoprotein molecules
insufficient secretion of Growth Hormone (GH) from the anterior
pituitary during childhood
dwarfism
over secreton of GH; over secretion can be associated with pituitary tumor
gigantism
anti-diuretic hormone (ADH) helps kidney tubules to reabsorb
water from kidney filtrate. Inadequate ADH receptors (or
defective receptors) of kidney tubule cells cause excessive urine production
diabetes insipidus
overactive thyroid functions; causing high metabolic rate, hyperactivity, weight loss,
heat sensitivity, goiter, etc.
hyperthyroidism (grave disease)
under active thyroid functions; causing low metabolic rate, hypoactivity or sluggishness, mental dullness, weight gain, cold sensitivity, etc.
hypothyroidism
occurs due to an iodine deficiency
simple goiter
diabetes mellitus type 1
- also called Juvenile-onset
- diabetes or Insulin
- dependent Diabetes
- appears before age 20
- caused by low insulin production
- treatment by insulin supplement
diabetes mellitus type 2
- non-insulin dependent
- milder form
- typically appears after age 40
- cells lose insulin receptors thus can not respond to insulin
- treatment: exercise, avoid carbohydrate, etc.
controls ACTH secretion (adrenocorticotropic hormone)
Corticotropin-releasing hormone (CRH)
releasing hormone (LHRH)); stimulates FSH and LH production (follicle stimulating hormone, luteinizing hormone)
Gonadotropin-releasing hormone (GnRH) (Luteinizing hormone releasing hormone (LHRH))
controls GH secretion (growth hormone)
Somatostatin (SS,) (Growth hormone release-inhibiting hormone (GIH))
controls PRL secretion (prolactin)
Prolactin release-inhibiting hormone (PIH)
stimulates PRL secretion (prolactin)
Prolactin-releasing factor (PRF)
controls TSH secretion (thyroid stimulating hormone)
Thyrotropin-releasing hormone (TRH)
controls hormone secretion from adrenal cortex
Adrenocorticotropic hormone (ACTH)/(Corticotropin
* anterior pituitary
egg development, stimulation of follicular cells to produce
estrogen
Follicle stimulating hormone (FSH)/ (Follitropin)
* anterior pituitary
cell growth and division
Growth hormone
(GH)/(Somatotropin (STH))
* anterior pituitary
necessary for androgens (male hormones) production
Luteinizing hormone (LH) (Lurtopin, Intestinal cell-stimulating hormone
(ICSH))
* anterior pituitary
prolactin (PRL)
- breast devlopment
- milk production
- decreases LH secretion males
- anterior pituitary
controls hormone secretion from the thyroid gland
Thyroid stimulating hormone (TSH)/(Thyrotropin)
* anterior pituitary
stimulates melanin synthesis
Melanocyte stimulating hormone (MSH)
* anterior pituitary
Antidiuretic hormone (ADH)/(Vasopressin)
- kidney water reabsorption
- vasoconstriction
- posterior pituitary
Oxytocin (OT)
- antidiuretic
- uterine contraction
- contraction of cells that produce and eject milk
- posterior pituitary
lowers blood calcium and phosphate levels
calcitonin
thyroxin (T-4); triiodothyronine (T-3)
- helps normal development of the nervous system
- increases metabolism
- increases protein synthesis and lipid breakdown
Parathyroid hormone (PTH)/(Parathormone)
- increases blood calcium
- decreases blood phosphate
- phosphate excretion and calcium retention by kidney
- calcium absorption gut (indirectly)
- parathyroid gland
same as epinephrine (adrenaline)
Norepinephrine (NE)/(Noradrenalin)
*parathyroid gland
aldosterone
- excretion of potassium
- conservation of sodium and water by kidney to maintain blood pressure
- adrenal cortex
cortisol (hydrocortisone)
- protein synthesis inhibition
- formation of glucose from non-carbohydrate
- adrenal cortex
supplement the hormones produced by the gonads (males and females)
adrenal sex hormones
* adrenal cortex
glucagon
- stimulates the liver to produce glucose
- increases blood glucose
- breaks down fats
- pancreas
insulin
- movement of glucose
- through cell membrane
- glucose and fat storage
- promotes protein synthesis
- pancreas
inhibits insulin and glucagon release
somatostatin
* pancreas
regulated day/nigh cycle
melatonin
* pineal gland
helps maturation of T-cells
thymosin
* thymus
development of secondary sexual characteristics
estrogen
* ovaries
controls cyclical changes in the uterus and the breast
progesterone
* ovaries
placenta
- estrogens
- progesterone
- gonadotropins ( are the FSH and LH)
produces testosterone
testes