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PGI > 8.7.2013(pathology)60 > Flashcards

8.7.2013(pathology)60 Flashcards

0
Q

Caspase 1

A

ICE

interleukin 1 beta converting enzyme

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1
Q

Caspases are

A

Cysteine dependant Aspartate directed proteases

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2
Q

Chromosomal alterations in oncocytoma

A

Deletions at 10q

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3
Q

Mutations in Dyskeratosis congenita

A

X linked - Dyskerin

AD- hTERC,hTERT(telomerase)

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4
Q

Histological types of malignant mesothelioma

A

Epithelial
Fibrous(Sarcomatoid)
Biphasic/mixed type

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5
Q

Gold standard for diagnosis of malignant mesothelioma

A

EM appearance of long branching microvilli

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6
Q

IHC of mesothelioma

A 
Pankeratin
Keratin 5/6
Calretinin
WT1
Negative for epithelial markers like CEA,CD15
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7
Q

Breast changes without increased risk of malignancy

A 
Duct ectasia
Cysts
Apocrine changes 
  Mild hyperplasia
  Adenosis
Fibroadenoma without complex features
Sclerosing adenosis
Intraductal papilloma
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8
Q

Breast changes associated with increased risk of malignancy

A

Florid hyperplasia
Atypical lobular hyperplasia
Atypical ductal hyperplasia
Ductal involvement by cells of atypical ductal hyperplasia(highest risk next only to in situ lesions)

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9
Q

Syndromes associated with breast cancer

A 
Li fraumeni 
Peutz jegher (STK11/LKB1)
Cowden
Muir torre(MSH2/MLH1)
Ataxia telangiectasia
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10
Q

Full name of bloom Richardson grading

A

Nottingham combined histologic grade of Elston Ellis modification of the scarf bloom Richardson grading system

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11
Q

HLA associated with juvenile Pauciarticular arthritis

A

DR8

DR5

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12
Q

HLA associated with rheumatoid arthritis

A

DR4

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13
Q

HLA associated with sjogren syndrome

A

DR3

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14
Q

HLA associated with SLE

A

Caucasian DR3

Japanese DR2

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15
Q

HLA associated with celiac disease

A

DQ2

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16
Q

HLA associated with dermatitis herpetiformis

A

DR3

17
Q

HLA associated with chronic active hepatitis

A

DR3

18
Q

HLA associated with psoriasis vulgaris

A

Cw6

19
Q

HLA associated with Pemphigus vulgaris

A

DR4

DQ1

20
Q

HLA associated with Bullous pemphigoid

A

DQ7

21
Q

HLA associated with DM1

A

DR2
DR3
DR4(commonly associated)
DQ8

22
Q

HLA associated with graves disease

A

B8

DR3

23
Q

HLA associated with adrenal insufficiency

A

DR3

24
Q

HLA associated with myasthenia gravis

A

B8

DR3

25
Q

HLA associated with multiple sclerosis

A

DR2

26
Q

HLA associated with Behcet disease

A

B51

27
Q

HLA associated with congenital adrenal hyperplasia

A

B47

28
Q

HLA associated with narcolepsy

A

DR2

29
Q

HLA associated with goodpasture syndrome

A

DR2

30
Q

Metastasis to heart arise from

A 
Lung
Breast
Melanoma
Leukemia
Lymphoma
31
Q

Appearance of amyloid in different stains

A 
H & E- pink,hyaline,homogenous
Methyl violet/crystal violet- metachromasia
Congo red
Thioflavin T and S
Toludene blue - orthochromatic blue
Alcian blue- blue green
PAS- pink
32
Q

Peutz jegher syndrome malignancy risk

A

2-10% risk for cancer of intestinal tract

33
Q

Tumors in PJ syndrome

A 
Ca breast
Ca lung
Ca thyroid
Ca cervix
Ca Fallopian tube
Ca ovary
Ca pancreas
Ca GB
Ca Billiary tract 
Ca testis
34
Q

Most common GIT polyp

A

Hyperplastic polyp

35
Q

Most common hamartomatous polyp

A

Juvenile polyposis syndrome

36
Q

Which is most common ?
FAP
HNPCC

A

HNPCC

but FAP is more malignant(100%)

37
Q

Surveillance for FAP and HNPCC

A

FAP 15 yrs

HNPCC 25 yrs or 10 years earlier of first degree relative developing polyps

38
Q

Tumors in Cowden syndrome

A

Breast(50%)

Thyroid

39
Q

Most common site of peutz jeghers syndrome

A

Jejunum

40
Q

Diff btw FAP and HNPCC in GIT malignancies

A

FAP
Benign Gastric polyp
Gall bladder Ca

PGI (16 decks)

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