Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PGI > 4.7.2013(pathology)57 > Flashcards

4.7.2013(pathology)57 Flashcards

0
Q

Bradykinin receptor involved in inflammatory response

A

B1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Drugs causing hemolysis in G6PD deficiency

A 
Primaquine
Chloroquine
Proguanil
Dapsone
Nalidixic acid
Ciprofloxacin
Norfloxacin
Nitrofurantoin 
Cotrimoxazole
Sulphasalazine
Aspirin at high dose
Methylene blue
Rsburicase
Vitamin K analogue
Acetanilide
Phenazopyridine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Bradykinin displays highest affinity for which type of receptor

A

B2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Potency of bradykinin compared to histamine

A

More potent vasodilator

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Prekallikrein is converted to kallikrein by

A

Hageman factor
Trypsin
Kallikrein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

LMW kininogen is converted to

A

Kallidin by tissue kallikrein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Kallidin is converted to bradykinin by

A

Aminopeptidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Kallidin is also known as

A

Lysyl bradykinin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Bradykinin and Kallidin are degraded by

A

Kinases I and II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Causes of hypertrophic cardiomyopathy(mutations)

A 
Beta myosin heavy chain 
Actin
Troponin T
Alpha tropomyosin
Troponin I
Myosin light chain
MYBPC
Titin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Mutations that may cause dilated cardiomyopathy

A 
Beta myosin heavy chain
Actin
Tropomyosin
Troponin T
Delta and beta sarcoglycans 
Dystrophin
Desmin
Lamin
Medium/long chain Acyl coA dehydrogenase
Carnitine transporter translocase
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cerebral infarction is caused by which fungal infections

A

Mucormycosis

Aspergillosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Carnitine deficiency is caused by which drug

A

Valproate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Causes of niacin deficiency

A

Alcoholism
Tryptophan deficiency
B6 deficiency
Riboflavin deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Sugar cell tumor $

A

Clear cell tumor of lung

Contains abundant PAS positive glycogen granules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Clear cell tumors

A 
Sarcomas
 Perivascular epitheloid cell tumors
Carcinomas
 Renal 
 Salivary gland
 Gall bladder
 Cervix
 Cholangiocarcinoma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Alfa fetoprotein elevation

A 
Hepatoma
Hepatoblastoma
Endodermal sinus tumor
Immature teratoma
Stomach Ca
Pancreatic Ca
Billiary ca
Lung ca
Hepatitis 
Cirrhosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Causes of raised maternal serum AFP

A 
Neural tube defects
Fetal death
Chorangioma
Omphalocele/gastroschisis
Intestinal obstruction
Cloacal exostrophy
Cystic hygroma
Pilonidal cysts
Sacrococygeal teratoma
Congenital nephrosis
Preeclampsia
Osteogenesis imperfecta
Placenta accreta
PCKD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Hairy cell leukemia pts are at increased risk of infections with

A

MAC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Rx of hairy cell leukemia

A

Cladribine
Pentostatin
Interferon alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Most common symptom of zollinger Ellison syndrome

A

Abdominal Pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Malignancy in zollinger Ellison syndrome

A

60-90%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Common symptom of zollinger Ellison syndrome arising from pancreas

A

Diarrhoea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Most common manifestation of extra pancreatic VIPoma

A

Hypokalemia

24
Most common presentation of Somatostatinoma
Diabetes(pancreas) | Cholelithiasis(duodenum/jejunum)
25
Causes of schistocytes
``` MAHA TTP HUS DIC Prosthetic valve March hemoglobinuria Hemangiosarcoma Myelofibrosis Glomerulonephritis Chronic doxorubicin toxicosis Severe iron deficiency Anemia Pyruvate kinase deficiency ```
26
Target cells causes
Absolute increase in surface area: obstructive liver disease | Relative increase due to diminished volume: fe deficiency,thalassemia,HbE,HbC
27
Acanthocytes,cause
Accumulation of cholesterol in outer lipid bilayer- liver disease Accumulation of sphingomyelin in outer lipid bilayer- abetalipoproteinemia
28
Echinocytes,causes
Expansion of outer lipid bilayer membrane relative to inner surface Uraemia Pyruvate kinase deficiency
29
Stomatocytes,cause
Expansion of inner surface of lipid bilayer relative to outer layer Vinca alkaloids Alcoholism Cation permeability disorder
30
Abnormal RBC morphology due to aberrant horizontal protein interactions
Ellipsocytosis | Poikilocytosis(severely impaired)
31
Dysplasia is a ________ change
Reversible
32
Features of dysplasia$
Architectural disorientation Pleomorphism Hyper chromatic and large nuclei Abundant mitotic figures
33
Causes of massive splenomegaly $
``` CML myelofibrosis with myeloid metaplasia Polycythemia Vera Hairy cell leukemia CLL diffuse splenic hemangiomatosis Autoimmune Hemolytic Anemia Sarcoidosis Gaucher ```
34
Transthyretin transports
Thyroxine | Retinol
35
Ear abnormalities in down
Serous otitis media | Conductive or sensorineural hearing loss
36
Dyskeratosis congenita
Hyperpigmentation Oral leukoplakia Dystrophic nails Aplastic Anemia
37
Mode of inheritance of Dyskeratosis congenita
X linked recessive(common) | Autosomal dominant
38
Cause of Prader willi and Angelman syndrome
Praderwilli- paternal deletion | Angelman-maternal deletion
39
Appearance of chromatin in neuroendocrine tumors
Salt and pepper
40
Types of nephrogenic rests
Sclerotic rests | Hyperplastic rests
41
Other name for nephrogenic rests
Nephroblastomatosis
42
Congenital Mesoblastic nephroma is common in
Males
43
Congenital Mesoblastic nephroma resembles
Leiomyoma
44
Congenital Mesoblastic nephroma produces
Renin
45
Site of metastasis of congenital Mesoblastic nephroma
They never metastasise
46
Anaplastic Wilms tumor $
Large,hyper chromatic,pleomorphic nuclei | Abnormal mitosis
47
Mesenchymal component of Wilms showing malignant differentiation
Rhabdomyosarcomatous wilms
48
Common causes of budd chiari syndrome
1. polycythemia rubra Vera 2. Pregnancy 3. Postpartum 4. OCP 5. PNH 6. HCC
49
Adenocarcinoma of small intestine is common in
Duodenum
50
Most common type of small intestinal lymphoma
Diffuse large B cell lymphoma
51
Site of DLBL of small intestine
Ileocecal junction
52
Rx of burkitt lymphoma of small bowel
Vincristine Cyclophosphamide Doxorubicin Methotrexate
53
Effecement of foot process is seen in
minimal change disease FSGS MPGN membranous glomerulonephritis
54
Von meyenberg complex
Bile duct micro hamartoma | Dilated bile ducts close to or within portal tracts
55
Causes of elevated CA125
``` Ovarian cancer Cervical ca Endometrium ca Fallopian tube Ca ca breast Ca pancreas Ca lung Ca colon Pregnancy Endometriosis PID abdominal TB uterine fibroids 1% of normal females ```
56
Markers of hairy cell leukemia
CD11c CD25 CD103
57
Causes of uniparental disomy
Meiotic nondisjunction Trisomy 15 Trisomy rescue by mitotic non dysjunction

PGI (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions