Sketchy Pharm: Rituximab, Cetuximab, Bevacizumab, Alemtuzumab, Trastuzumab Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

What kind of antibody is rituximab?

A

Chimeric

(You know this from the -ximab suffix, but Sketchy also has the guy in the coronation RITUal having a chimera on his cloak.)

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2
Q

What surface receptor does rituximab bind?

A

CD20

(This is symbolized by the archers next to the RITUal –archers being Sketchy’s symbol for B cells –and they have two X’s on their tunics to help you remember 20.)

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3
Q

For what diseases is rituximab used?

A
  • T-cell and B-cell malignancies (represented by the quilt with the archers and knights)
  • Autoimmune disorders caused or aggravated by B cells (like the RA lamps above the ritual)
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4
Q

What are side effects of rituximab?

A
  • Immunosuppression with repeated use (pope with cane)
  • PML (guy with white laurels)
  • Pruritus, swelling, headache, and fever soon after IV administration (swollen cherub with red skin swinging on ivy)
  • Serum sickness one week after use (coronated guy with red skin; the murderer made the poison slow-onset to get away)
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5
Q

How can the IV reactions to rituximab be treated?

A

NSAIDs and antihistamines

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6
Q

Serum sickness is treatable with ______________.

A

steroids

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7
Q

What receptor does cetuximab target?

A

EGFR

(This symbol is a little obtuse: the elephant’s TUsks should remind you of ceTUximab, and the elephant’s saddle has GiRaFfEs on it.)

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8
Q

What cancers can be treated with cetuximab?

A

Colorectal cancer and squamous cell carcinoma

These make sense because they’re both epithelial cancers.

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9
Q

Just to help tie things together, what small molecule inhibitor targets the same pathway as cetuximab?

A

Erlotinib (remember GEoFfRey –the EaRL Of TINIB?)

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10
Q

What are side effects of cetuximab?

A
  • Pruritus, swelling, headache, and fever soon after IV administration (swollen cherub with red skin swinging on ivy)
  • Acneiform rash (like the red spots on the giraffes –also the same effect as erlotinib)
  • Serum sickness (the elephant also drank the poisoned chalice)
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11
Q

Bevacizumab targets _____________.

A

VEGF (like the BEVerage lady poisoning the red punch next to chopped VEGetables)

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12
Q

What diseases are treatable with bevacizumab?

A
  • Metastatic cancers

* Wet macular degeneration (like the retina platter that the waitress is bringing the poisoned punch on)

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13
Q

What are side effects of bevacizumb?

A
  • Bleeding (like the punch spilled on the servants’ aprons) –because of this, bevacizumab is contraindicated in those who’ve recently had surgery
  • Thromboembolic events (like the thrombus floating in the poisoned punch)
  • Intestinal perforation (like the haustra-shaped vegetable bag that split open on the floor beneath the table)
  • Pruritus, swelling, headache, and fever soon after IV administration (swollen cherub with red skin swinging on ivy)
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14
Q

Alemtuzumab targets ____________.

A

the CD52 receptor on T cells and B cells (like the guy begging for ALMs from the archer and knight)

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15
Q

What does trastuzumab target?

A

The HER2/neu tyrosine kinase

Think of the woman working on the TrASTuzumab TApeSTry with HER 2 NEWborns.

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16
Q

What side effects are associated with trastuzumab?

A
  • Slight decrease in LVEF (like the torn heart design in the tapestry)
  • Pruritus, swelling, headache, and fever soon after IV administration (swollen cherub with red skin swinging on ivy)