5.4 Adrenals

Question 0

Formation of all corticosteroids starts with conversion of cholesterol to pregnenolone catalyzed by

Answer 0

SCC aka 20, 22 desmolase w/c is a rate-limiting enzyme and Major site of ACTH action

Question 1

Most important source of cholesterol

Answer 1

LDL

Question 2

For cholesterol to be transported from cytosolic to inner mitochondrial membrane, a carrier protein called ________ is needed

Answer 2

Steroidogenic acute regulatory protein (StAR)

Question 3

Important enzyme in synthesis of cortisol that is substantially found in zona fasciculata and reticularis

Answer 3

17-@hydroxylase

Question 4

Type 1 HSD is a
A. Bidirectional enzyme
B. Unilateral enzyme

Answer 4

A. Bidirectional enzyme

Type 2 is a unidirectional enzyme

Note:
Type 1 present in liver, bone, muscle, adipose tissue, and gonads

Type 2 present in kidney and other target organs of aldosterone

Question 5

Secreted in greatest amount
A. DHEA
B. DHEA- S
C. Testosterone

Answer 5

B. DHEA- S

Note:
Testosterone- most potent