5.10 Sex Determination Flashcards
Gonadal sex is controlled by the presence or absence of
TDF testis determining factor (which is contained in the SRY region of Y chromosome)
Genetic Sex is determined with the presence or absence of which chromosome
Y
Precursor of female internal sec organs
Mullerian system
Precursor of male internal sex organs
Wolffian system
External genitalia is determined by presence or absence of
Testosterone
(-) testosterone - female genitalia develops
(+) testosterone - male genitalia develops
Urogenital folds differentiates to become
A. Labia majora
B. Labia minora
A. Labia majora - from labioscrotal swellings
B. Labia minora - correct answer
Gender of baby can be determined starting on the ____mos of pregnancy using the ultrasound
3rd month
Secondary sex characteristics are determined at
A. School age
B. Adulthood
C. Puberty
C. Puberty
Thelarche or breast enlargement start at what age in females
8 years old
Pubarche and menarche start at this age
11 years old
Thorarche and ovularche start at this age
14 years old
Diamond pubic hair
A. Male b. Female
Male- correct
Female- triangular
Characterized by Turner syndrome, absence of ovaries but with female external genitalia
Gonadal dysgenesis - only 1 X chromosome
Has XXX chromosome
Superfemale
An example of seminiferous tubule dysgenesis
Klinefelter’s syndrome - XY with additional X chromosome
Genetically female but gonads are male
Female pseudohermaphroiditism
Congenital 17@-hydroxylase deficiency
Male pseudohermaphroiditism
Occurs when a patient has 46 XY chromosome but with a normal female appearance
Androgen insensitivity syndrome
Differentiate true precocious puberty and precocious puberty
True precocious - cerebral tumors
Precocious - adrenal tumors, Leydig and granulosa cell tumors
External genitalia: DHT, internal genitalia : _____
AMH
Determined at fertilization A. Genetic sex B. Genital sex C. Gonadal sex D. Physiological sex
A. Genetic sex
Phenotypic sex A. Genetic sex B. Genital sex C. Gonadal sex D. Physiological sex
B. Genital sex
Presence of SRY A. Genetic sex B. Genital sex C. Gonadal sex D. Physiological sex
C. Gonadal sex - correct
